Tema Con Variazioni: Quantum Channel Capacity

Channel capacity describes the size of the nearly ideal channels, which can be obtained from many uses of a given channel, using an optimal error correcting code. In this paper we collect and compare minor and major variations in the mathematically precise statements of this idea which have been put forward in the literature. We show that all the variations considered lead to equivalent capacity definitions. In particular, it makes no difference whether one requires mean or maximal errors to go to zero, and it makes no difference whether errors are required to vanish for any sequence of block sizes compatible with the rate, or only for one infinite sequence.Comment: 32 pages, uses iopart.cl

Typical support and Sanov large deviations of correlated states

Discrete stationary classical processes as well as quantum lattice states are asymptotically confined to their respective typical support, the exponential growth rate of which is given by the (maximal ergodic) entropy. In the iid case the distinguishability of typical supports can be asymptotically specified by means of the relative entropy, according to Sanov's theorem. We give an extension to the correlated case, referring to the newly introduced class of HP-states.Comment: 29 pages, no figures, references adde

The nucleotide and partial amino acid sequences of rat fetuin

Fetuins are among the major plasma proteins, yet their biological role has remained elusive. Here we report the molecular cloning of rat fetuin and the sequence analysis of a full-length clone, RF619 of 1456 bp with an open reading frame of 1056 bp encoding 352 amino acid residues. The coding part of RF619 was identical with the cDNA sequence of the natural inhibitor of the insulin receptor tyrosine kinase from rat (pp63) except for four substitutions and a single base insertion causing divergence of the predicted protein sequences. Partial amino acid sequences of rat plasma fetuin were in agreement with the predictions based on the RF619 cDNA. Purified rat fetuin inhibited the insulin receptor tyrosine kinase in vitro. Therefore, we conclude that RF619 and pp63 cDNA encode the same protein, i.e. authentic rat fetuin which is a functional tyrosine kinase inhibitor

Extraction of electromagnetic neutron form factors through inclusive and exclusive polarized electron scattering on polarized 3He target

Inclusive 3He(e,e') and exclusive 3He(e,e'n) processes with polarized electrons and 3He have been theoretically analyzed and values for the magnetic and electric neutron form factors have been extracted. In both cases the form factor values agree well with the ones extracted from processes on the deuteron. Our results are based on Faddeev solutions, modern NN forces and partially on the incorporation of mesonic exchange currents.Comment: 28 pages, 29 Postscript figure

Interpreting Attoclock Measurements of Tunnelling Times

Resolving in time the dynamics of light absorption by atoms and molecules, and the electronic rearrangement this induces, is among the most challenging goals of attosecond spectroscopy. The attoclock is an elegant approach to this problem, which encodes ionization times in the strong-field regime. However, the accurate reconstruction of these times from experimental data presents a formidable theoretical challenge. Here, we solve this problem by combining analytical theory with ab-initio numerical simulations. We apply our theory to numerical attoclock experiments on the hydrogen atom to extract ionization time delays and analyse their nature. Strong field ionization is often viewed as optical tunnelling through the barrier created by the field and the core potential. We show that, in the hydrogen atom, optical tunnelling is instantaneous. By calibrating the attoclock using the hydrogen atom, our method opens the way to identify possible delays associated with multielectron dynamics during strong-field ionization.Comment: 33 pages, 10 figures, 3 appendixe

Pseudo-single crystal electrochemistry on polycrystalline electrodes : visualizing activity at grains and grain boundaries on platinum for the Fe2+/Fe3+ redox reaction

The influence of electrode surface structure on electrochemical reaction rates and mechanisms is a major theme in electrochemical research, especially as electrodes with inherent structural heterogeneities are used ubiquitously. Yet, probing local electrochemistry and surface structure at complex surfaces is challenging. In this paper, high spatial resolution scanning electrochemical cell microscopy (SECCM) complemented with electron backscatter diffraction (EBSD) is demonstrated as a means of performing ‘pseudo-single-crystal’ electrochemical measurements at individual grains of a polycrystalline platinum electrode, while also allowing grain boundaries to be probed. Using the Fe2+/3+ couple as an illustrative case, a strong correlation is found between local surface structure and electrochemical activity. Variations in electrochemical activity for individual high index grains, visualized in a weakly adsorbing perchlorate medium, show that there is higher activity on grains with a significant (101) orientation contribution, compared to those with (001) and (111) contribution, consistent with findings on single-crystal electrodes. Interestingly, for Fe2+ oxidation in a sulfate medium a different pattern of activity emerges. Here, SECCM reveals only minor variations in activity between individual grains, again consistent with single-crystal studies, with a greatly enhanced activity at grain boundaries. This suggests that these sites may contribute significantly to the overall electrochemical behavior measured on the macroscale

Tumor-Induced Cholesterol Efflux from Macrophages Drives IL-4 Mediated Reprogramming and Tumor Progression

Tumor-associated macrophages (TAM) have been shown to have important roles in the malignant progression of various cancers. However, macrophages also posses intrinsic tumoricidal activity and can promote the activity of cytotoxic lymphocytes, but they rapidly adopt an alternative phenotype within tumors, associated with immune-suppression and trophic functions that support tumor growth. The mechanisms that promote TAM polarization in the tumor-microenvironment remain poorly understood, these mechanisms may represent important therapeutic targets to block the tumor-promoting functions of TAM and restore their anti-tumor potential. Here we have characterized TAM in a mouse model of metastatic ovarian cancer. We show that ovarian cancer cells promote membrane-cholesterol efflux and the depletion of lipid rafts from macrophages. Increased cholesterol efflux promoted IL-4 mediated reprogramming while inhibiting IFNγ-induced gene expression. These studies reveal an unexpected role for tumor-induced membrane-cholesterol efflux in driving the IL-4 signaling and the tumor-promoting functions of TAM, while rendering them refractory to pro-inflammatory stimuli. Thus, preventing cholesterol efflux in TAM could represent a novel therapeutic strategy to block pro-tumor functions and restore anti-tumor immunity. Biopharmaceutic

PROJECT-J: JWST observations of HH46~IRS and its outflow. Overview and first results

We present the first results of the JWST program PROJECT-J (PROtostellar JEts Cradle Tested with JWST ), designed to study the Class I source HH46 IRS and its outflow through NIRSpec and MIRI spectroscopy (1.66 to 28 micron). The data provide line-images (~ 6.6" in length with NIRSpec, and up to 20" with MIRI) revealing unprecedented details within the jet, the molecular outflow and the cavity. We detect, for the first time, the red-shifted jet within ~ 90 au from the source. Dozens of shock-excited forbidden lines are observed, including highly ionized species such as [Ne III] 15.5 micron, suggesting that the gas is excited by high velocity (> 80 km/s) shocks in a relatively high density medium. Images of H2 lines at different excitations outline a complex molecular flow, where a bright cavity, molecular shells, and a jet-driven bow-shock interact with and are shaped by the ambient conditions. Additional NIRCam 2 micron images resolve the HH46 IRS ~ 110 au binary system and suggest that the large asymmetries observed between the jet and the H2 wide angle emission could be due to two separate outflows being driven by the two sources. The spectra of the unresolved binary show deep ice bands and plenty of gaseous lines in absorption, likely originating in a cold envelope or disk. In conclusion, JWST has unraveled for the first time the origin of the HH46 IRS complex outflow demonstrating its capability to investigate embedded regions around young stars, which remain elusive even at near-IR wavelengths.Comment: 28 pages, 15 figures, Accepted for publication on The Astrophysical Journal (9 April 2024