548 research outputs found
Subcutaneous Haemangiosarcoma in a Cockatiel ( Nymphicus hollandicus )
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74932/1/j.1439-0442.2006.00825.x.pd
Electronic Structure and Lattice Relaxation Related to Fe in Mgo
The electronic structure of Fe impurity in MgO was calculated by the linear
muffin-tin orbital--full-potential method within the conventional local-density
approximation (LDA) and making use of the LDA+ formalism. The importance of
introducing different potentials, depending on the screened Coulomb integral
, is emphasized for obtaining a physically reasonable ground state of the
Fe ion configuration. The symmetry lowering of the ion electrostatic
field leads to the observed Jahn--Teller effect; related ligand relaxation
confined to tetragonal symmetry has been optimized based on the full-potential
total energy results. The electronic structure of the Fe ion is also
calculated and compared with that of Fe.Comment: 13 pages + 4 PostScript figures, Revtex 3.0, SISSA-CM-94-00
Facial expressions depicting compassionate and critical emotions: the development and validation of a new emotional face stimulus set
Attachment with altruistic others requires the ability to appropriately process affiliative and kind facial cues. Yet there is no stimulus set available to investigate such processes. Here, we developed a stimulus set depicting compassionate and critical facial expressions, and validated its effectiveness using well-established visual-probe methodology. In Study 1, 62 participants rated photographs of actors displaying compassionate/kind and critical faces on strength of emotion type. This produced a new stimulus set based on N = 31 actors, whose facial expressions were reliably distinguished as compassionate, critical and neutral. In Study 2, 70 participants completed a visual-probe task measuring attentional orientation to critical and compassionate/kind faces. This revealed that participants lower in self-criticism demonstrated enhanced attention to compassionate/kind faces whereas those higher in self-criticism showed no bias. To sum, the new stimulus set produced interpretable findings using visual-probe methodology and is the first to include higher order, complex positive affect displays
Development of a prototype superconducting radio-frequency cavity for conduction-cooled accelerators
The higher efficiency of superconducting radio-frequency (SRF) cavities
compared to normal-conducting ones enables the development of high-energy
continuous-wave linear accelerators (linacs). Recent progress in the
development of high-quality NbSn film coatings along with the availability
of cryocoolers with high cooling capacity at 4 K makes it feasible to operate
SRF cavities cooled by thermal conduction at relevant accelerating gradients
for use in accelerators. A possible use of conduction-cooled SRF linacs is for
environmental applications, requiring electron beams with energy of
MeV and 1 MW of power. We have designed a 915 MHz SRF linac for such an
application and developed a prototype single-cell cavity to prove the proposed
design by operating it with cryocoolers at the accelerating gradient required
for 1 MeV energy gain. The cavity has a m thick NbSn film on
the inner surface, deposited on a mm thick bulk Nb substrate and a bulk
mm thick Cu outer shell with three Cu attachment tabs. The cavity was
tested up to a peak surface magnetic field of 53 mT in liquid He at 4.3 K. A
horizontal test cryostat was designed and built to test the cavity cooled with
three Gifford-McMahon cryocoolers. The rf tests of the conduction-cooled
cavity, performed at General Atomics, achieved a peak surface magnetic field of
50 mT and stable operation was possible with up to 18.5 W of rf heat load. The
peak frequency shift due to microphonics was 23 Hz. These results represent the
highest peak surface magnetic field achieved in a conduction-cooled SRF cavity
to date and meet the requirements for a 1 MeV energy gain
Outcome of Reverse Switching From CT-P13 to Originator Infliximab in Patients With Inflammatory Bowel Disease
BACKGROUND: Patients suffering from inflammatory bowel diseases (IBD) and treated with originator infliximab are increasingly being switched to biosimilars. Some patients, however, are "reverse switched" to treatment with the originator. Here we assess the prevalence of reverse switching, including its indication and outcomes. METHODS: In this retrospective multicenter cohort study, data on patients with IBD from 9 hospitals in the Netherlands were collected. All adult patients with IBD were included if they previously had been switched from originator infliximab to the biosimilar CT-P13 and had a follow-up time of at least 52 weeks after the initial switch. The reasons for reverse switching were categorized into worsening gastrointestinal symptoms, adverse effects, or loss of response to CT-P13. Drug persistence was analyzed through survival analyses. RESULTS: A total of 758 patients with IBD were identified. Reverse switching was observed in 75 patients (9.9%). Patients with reverse switching were predominantly female (70.7%). Gastrointestinal symptoms (25.5%) and dermatological symptoms (21.8%) were the most commonly reported reasons for reverse switching. In 9 patients (12.0%), loss of response to CT-P13 was the reason for reverse switching. Improvement of reported symptoms was seen in 73.3% of patients after reverse switching and 7 out of 9 patients (77.8%) with loss of response regained response. Infliximab persistence was equal between patients who were reverse-switched and those who were maintained on CT-P13. CONCLUSIONS: Reverse switching occurred in 9.9% of patients, predominantly for biosimilar-attributed adverse effects. Switching back to originator infliximab seems effective in patients who experience adverse effects, worsening gastrointestinal symptoms, or loss of response after switching from originator infliximab to CT-P13
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Design and Fabrication of the RHIC Electron-Cooling Experiment High Beta Cavity and Cryomodule
The summary of this report is: (1) A high-current SRF cavity for an Energy Recovery Linac (ERL) has been designed by BNL and AES and fabricated by AES; (2) The cavity was cleaned and tested by JLAB with BNL personnel support; (3) Cavity performance exceeded goal of 20 MV/m at Q{sub 0} > 1 x 10{sup 10} and far exceeded requirement of 15 MV/m at Q{sub 0} > 1 x 10{sup 10}; (4) Hermetic String assembled at JLAB with BNL personnel support and shipped to BNL; and (5) BNL has recently completed Cryomodule assembly and unit is ready for installation in the ERL vault
Cellularly-Driven Differences in Network Synchronization Propensity Are Differentially Modulated by Firing Frequency
Spatiotemporal pattern formation in neuronal networks depends on the interplay between cellular and network synchronization properties. The neuronal phase response curve (PRC) is an experimentally obtainable measure that characterizes the cellular response to small perturbations, and can serve as an indicator of cellular propensity for synchronization. Two broad classes of PRCs have been identified for neurons: Type I, in which small excitatory perturbations induce only advances in firing, and Type II, in which small excitatory perturbations can induce both advances and delays in firing. Interestingly, neuronal PRCs are usually attenuated with increased spiking frequency, and Type II PRCs typically exhibit a greater attenuation of the phase delay region than of the phase advance region. We found that this phenomenon arises from an interplay between the time constants of active ionic currents and the interspike interval. As a result, excitatory networks consisting of neurons with Type I PRCs responded very differently to frequency modulation compared to excitatory networks composed of neurons with Type II PRCs. Specifically, increased frequency induced a sharp decrease in synchrony of networks of Type II neurons, while frequency increases only minimally affected synchrony in networks of Type I neurons. These results are demonstrated in networks in which both types of neurons were modeled generically with the Morris-Lecar model, as well as in networks consisting of Hodgkin-Huxley-based model cortical pyramidal cells in which simulated effects of acetylcholine changed PRC type. These results are robust to different network structures, synaptic strengths and modes of driving neuronal activity, and they indicate that Type I and Type II excitatory networks may display two distinct modes of processing information
Collective phase description of globally coupled excitable elements
We develop a theory of collective phase description for globally coupled
noisy excitable elements exhibiting macroscopic oscillations. Collective phase
equations describing macroscopic rhythms of the system are derived from
Langevin-type equations of globally coupled active rotators via a nonlinear
Fokker-Planck equation. The theory is an extension of the conventional phase
reduction method for ordinary limit cycles to limit-cycle solutions in
infinite-dimensional dynamical systems, such as the time-periodic solutions to
nonlinear Fokker-Planck equations representing macroscopic rhythms. We
demonstrate that the type of the collective phase sensitivity function near the
onset of collective oscillations crucially depends on the type of the
bifurcation, namely, it is type-I for the saddle-node bifurcation and type-II
for the Hopf bifurcation.Comment: 18 pages, 6 figure
Reading the face of a leader: women with low facial masculinity are perceived as competitive
In competitive settings, people prefer leaders with masculine faces. But is facial masculinity a trait that is similarly desired in men and women leaders? Across three studies, we discovered that people indeed prefer men and women leaders who have faces with masculine traits. But surprisingly, we find that people also prefer women with low facial masculinity as leaders in competitive contexts (Study 1). Our findings indicate that low facial masculinity in women, but not in men is perceived to indicate competitiveness (Study 2). Thus, in contrast to men, women
leaders who rate high in facial masculinity as well as those low in facial masculinity are both selected as leaders in competitive contexts. Indeed, among CEOs of S&P 500 companies, we find a greater range of facial masculinity amongwomen CEOs than among men CEOs (Study 3). Our results suggest that traits of facial masculinity in men and women are interpreted differently. Low facial masculinity in women is linked to competitiveness and not only to cooperativeness
as suggested by prior research
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