Reorganisation der industriellen Beziehungen im europäischen Mehrebenensystem

"In der Europäischen Union vollzog sich in den 90er Jahren eine Wiederbelebung und Transformation korporatistischer Arrangements. Hierbei handelt es sich um einen doppelten Reorganisationsprozess, der einerseits durch die markt- und wettbewerbsgetriebene Modernisierung der europäischen Ökonomie, andererseits zugleich aber auch durch spezifische Formen der Konzertierung und Kompromissbildung auf betrieblicher, nationaler und europäischer Ebene bestimmt ist. Die bestehenden Regelsysteme und Kompromissstrukturen werden demnach einem erhöhten Wettbewerbsdruck ausgesetzt, ohne dass allerdings die Beteiligung und Einbindung der Beschäftigten und Gewerkschaften grundsätzlich in Frage gestellt wird. Da die neuen Formen der sozialen Konzertierung und korporatistischen Interessenaushandlung jedoch stark asymmetrisch strukturiert sind, bleibt ihre Funktionsweise prekär." (Autorenreferat)"Corporatist arrangements were revitalised and transformed in the European Union in the course of the 1990s. This development arose from a two-fold process of reorganisation. Part of this was due to the modernisation of the European economy which was driven by market and competitive pressures. Part was driven by specific forms of concertation and compromise building at firm, national and European levels. Existing systems of regulation and conflict resolution were therefore exposed to increased pressure from competition, but without challenging the participation and involvement of employees and trade unions in principle. However, as the new forms of social concertation and corporatist interest inter-mediation are mostly structured asymmetrically, their effectiveness remains precarious." (author's abstract

Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade sarcoma of the distal extremities characterized by a myxohyaline stroma, a dense inflammatory infiltrate and virocyte- and lipoblast-like giant cells. Up to now, only two cases have been investigated cytogenetically, showing complex and heterogeneous karyotypes, in part with supernumerary ring chromosomes. We characterized two further cases of MIFS immunohistochemically and performed comparative genomic hybridization as well as DNA image cytometry analyses. Both tumors showed the characteristic histomorphological pattern of MIFS and were positive for Vimentin and CD68. Moreover, both cases presented aberrant karyotypes including distinct DNA copy number changes involving chromosome 7 and disclosed DNA aneuploid

Определение объема вычислительных экспериментов при решении задач оптимизационного синтеза динамических систем методом ПЛП-поиска

Даются рекомендации по выбору необходимого числа машинных экспериментов при решении конкретных задач исследования и оптимального проектирования методом ПЛП-поиска, позволяющего осуществлять глобальный квазиравномерный просмотр заданной области варьируемых параметров и применить формальные оценки из математической статистики.Recommendations about the choice of necessary number of machine experiments at the solution of specific objectives of a research and optimum design are made by method of the PLP-search allowing to carry out global quasi uniform viewing of the set area of the varied parameters and to apply formal estimates from mathematical statistics

Устройство автоматического регулирования жидкости

Although the significance of tumour site for estimating malignant potential in gastrointestinal stromal tumours (GISTs) has recently been recognized, site-specific genetic patterns have not to date been defined. This study examined 52 c-kit-positive primary GISTs (with a mean follow-up of 42.3 months in 51 cases) from three different locations (35 gastric, 12 small intestinal, and five colorectal) using comparative genomic hybridization (CGH). In general, tumour site correlated with key prognostic factors, including tumour size, mitotic rate, proliferative activity, and probable malignant potential. Furthermore, several DNA copy number changes showed a site-dependent pattern. These included losses at 14q (gastric 83%, intestinal 35%; p = 0.001), losses at 22q (gastric 46%, intestinal 82%; p = 0.02), losses at 1p (gastric 23%, intestinal 88%; p = 1 × 10-5), losses at 15q (gastric 14%, intestinal 59%; p = 0.002), losses at 9q (gastric 14%, intestinal 53%; p = 0.006), and gains at 5p (gastric 11%, intestinal 53%; p = 0.002). These data demonstrate strong site-dependent genetic heterogeneity in GISTs that may form a basis for subclassification. Prognostic evaluation of DNA copy number changes identified losses at 9q as a site-independent prognostic marker associated with shorter disease-free survival (p = 0.03) and overall survival (p = 0.002). Furthermore, 9q loss also appeared to carry prognostic value in predicting overall survival for patients with advanced or progressive GISTs (p = 0.003). Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd