The Molecularly Imprinted Polymers. Influence of Monomers on The Properties of Polymers - A Review

The synthesis of MIPs for two types of templates (herbicides, and flavonoids) and their application in analytical chemistry are discussed. Particular attention has been paid the issue of bonding the template and selection of appropriate monomer in different types of compounds. This short review aims at presenting the molecular imprinting technology (MIT) which is considered as an attractive method to produce impressive receptors for application in analytical chemistry. The challenge of designing and synthesizing a molecularly imprinted polymer (MIP) can be a daunting prospect to the uninitiated practitioner, simply because of the number of experimental variables involved, e.g. the nature and levels of template, functional monomers, cross-linkers, solvents, initiators and even the method of initiation and the duration of polymerization. Indubitably, the most important place of the polymer is its quotheartquot or the cavity corresponding to the template and the waynbs

Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients:an EBMT Transplant Complications Working Party study

The current incidence, diagnostic policy, management, and outcome of VOD/SOS at EBMT centers were studied. All centers that had performed allogeneic HSCTs in adult patients within one defined year were invited to the study. Seventy-one centers participated with a total of 2886 allogeneic transplantations and 93 cases of VOD/SOS in 2018. The cumulative incidence of VOD/SOS at day 21 was 1.8% and at day 100 2.4%. Of 67 cases with detailed data, 52 were classical and 15 (22%) late onset (&gt;day 21). According to the EBMT criteria, 65/67 patients had at least two VOD/SOS risk factors. The severity grades were: mild 0, moderate 3, severe 29, very severe 35. Fifty-four patients were treated with defibrotide. VOD/SOS resolved in 58% of the patients, 3/3 with moderate, 22/28 with severe, and 12/33 with very severe grade (p &lt; 0.001). By day 100, 57% of the patients were alive; 3/3 with moderate, 22/29 with severe, and 13/35 with very severe VOD/SOS (p = 0.002). In conclusion, the incidence of VOD/SOS was low. Severe and very severe grades dominated. Very severe grade predicted poor outcome compared to severe grade further supporting the concept of early diagnosis and treatment to avoid a dismal outcome. [Figure not available: see fulltext.]</p