The Livelihoods concept integrated into the DPSIR analytical tool

DPSIR stands for Drivers, Pressures, State, Impact, and Responses. DPSIR is an analytical tool used to understand the causes of environmental change and the subsequent socio-economic impacts in order to formulate the most adequate responses (R). It is a linear cause-effect model. It assumes natural and human-made factors of change (Drivers) that cause Pressures, which in turn lead to a change in the State of the environment. Changes in State lead to socio-economic Impacts and this triggers Reponses, either by governments or other players. The DPSIR analytical tool was originally proposed by the European Environmental Agency and adopted by many national and European institutions, EEA, and Eurostat among other

Potential for up-scaling Nimr reed bed facilities, Oman : feasibility study

This report describes the findings of a feasibility study to treat oil contaminated water using reed beds, and consume the treated saline water using forestry. The feasibility study focused on the social, technical and economical feasibility of a project designed to process 45,000 m3 of water per day. Possible effects of a large scale operation on interactions between Petroleum Development Oman and local population are listed, and suggestions on the social processes involved are made. The economics of reed bed water treatment and water consumption through the use of forestry are determined and compared with the current practise of deep well disposal. The economics of the treatment-forestry system are more favorable than the economics of the deep well disposal. The technical analysis shows that the reed beds are able to treat water to remove hydrocarbons, and suggestions for management, design and development of the system are given

Proceedings of the International Workshop on: methods and tools for water-related adaptation to climate change and climate proofing

The workshop fits in the National Water Plan of the Netherlands’ government of which the international chapter includes the strengthening of cooperation with other delta countries, including Indonesia, Vietnam and Bangladesh and is part of the work plan of the Cooperative Programme on Water and Climate, a Netherlands’ sponsored programme with the objective to improve knowledge and capacity on the relation between water and climate change especially in developing countries and countries in transition

Working with farmers; towards a service approach in irrigation; training; the socio-economic base line survey

Water management in rural areas is becoming more complex, increasing the need to communicate more intensely with water users. The trend to decentralize decision making in water management and to make those who render water management services answerable to the clients of their services, only enforces this. The intention of this report is to acquaint the community with a technical training in the methods and techniques that social scientists apply when working with farmers. They can be either managers responsible for all operations of a project or water management organization, staff charged with the task to supervise social scientists, or staff working together with social scientists and applying their results. The report may also be appreciated by social scientists who wish to refresh their knowledg

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion

Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles

CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients

Background:The CXC chemokine receptor (CXCR)7 is involved in tumour development and metastases formation. The aim of the present study was to determine protein expression of CXCR7, its putative co-receptors epidermal growth factor receptor (EGFR) and CXCR4, its predominant ligand CXCL12, their co-dependency and their association with survival in cervical cancer patients.Methods:CXC chemokine receptor 7, EGFR, CXCR4 and CXCL12 expression were determined immunohistochemically in 103 paraffin-embedded, cervical cancers. Subsequently, associations with patient characteristics were assessed and survival analyses were performed.Results:CXC chemokine receptor 7 was expressed by 43% of tumour specimens, in a large majority of cases together with either EGFR or CXCR4 (double positive), or both (triple positive). The CXCR7 expression was associated with tumour size (P=0.013), lymph node metastasis (P=0.001) and EGFR expression (P=0.009). CXC chemokine receptor 7 was independently associated with disease-free survival (hazard ratio (HR)=4.3, 95% confidence intervals (CI) 1.7-11.0, P=0.002), and strongly associated with disease-specific survival (HR=3.9, 95% CI 1.5-10.2, P=0.005).Conclusion:CXC chemokine receptor 7 expression predicts poor disease-free and disease-specific survival in cervical cancer patients, and might be a promising new therapeutic marker. In a large majority of cases, CXCR7 is co-expressed with CXCR4 and/or EGFR, supporting the hypothesis that these receptors assist in CXCR7 signal transduction.Cervix cance