3,204 research outputs found
DDF and Pohlmeyer invariants of (super)string
We show how the Pohlmeyer invariants of the bosonic string are expressible in
terms of DDF invariants. Quantization of the DDF observables in the usual way
yields a consistent quantization of the algebra of Pohlmeyer invariants.
Furthermore it becomes straightforward to generalize the Pohlmeyer invariants
to the superstring as well as to all backgrounds which allow a free field
realization of the worldsheet theory.Comment: 17 pp, minor typos corrected, references to papers by Isaev and
Borodulin added, which contain essentially the same results as reported her
A laser gyroscope system to detect the Gravito-Magnetic effect on Earth
Large scale square ring laser gyros with a length of four meters on each side
are approaching a sensitivity of 1x10^-11 rad/s/sqrt(Hz). This is about the
regime required to measure the gravitomagnetic effect (Lense Thirring) of the
Earth. For an ensemble of linearly independent gyros each measurement signal
depends upon the orientation of each single axis gyro with respect to the
rotational axis of the Earth. Therefore at least 3 gyros are necessary to
reconstruct the complete angular orientation of the apparatus. In general, the
setup consists of several laser gyroscopes (we would prefer more than 3 for
sufficient redundancy), rigidly referenced to each other. Adding more gyros for
one plane of observation provides a cross-check against intra-system biases and
furthermore has the advantage of improving the signal to noise ratio by the
square root of the number of gyros. In this paper we analyze a system of two
pairs of identical gyros (twins) with a slightly different orientation with
respect to the Earth axis. The twin gyro configuration has several interesting
properties. The relative angle can be controlled and provides a useful null
measurement. A quadruple twin system could reach a 1% sensitivity after 3:2
years of data, provided each square ring has 6 m length on a side, the system
is shot noise limited and there is no source for 1/f- noise.Comment: 9 pages, 6 figures. 2010 Honourable mention of the Gravity Research
Foundation; to be published on J. Mod. Phys.
Direct measurement of diurnal polar motion by ring laser gyroscopes
We report the first direct measurements of the very small effect of forced
diurnal polar motion, successfully observed on three of our large ring lasers,
which now measure the instantaneous direction of Earth's rotation axis to a
precision of 1 part in 10^8 when averaged over a time interval of several
hours. Ring laser gyroscopes provide a new viable technique for directly and
continuously measuring the position of the instantaneous rotation axis of the
Earth and the amplitudes of the Oppolzer modes. In contrast, the space geodetic
techniques (VLBI, SLR, GPS, etc.) contain no information about the position of
the instantaneous axis of rotation of the Earth, but are sensitive to the
complete transformation matrix between the Earth-fixed and inertial reference
frame. Further improvements of gyroscopes will provide a powerful new tool for
studying the Earth's interior.Comment: 5 pages, 4 figures, agu2001.cl
Principal 2-bundles and their gauge 2-groups
In this paper we introduce principal 2-bundles and show how they are
classified by non-abelian Cech cohomology. Moreover, we show that their gauge
2-groups can be described by 2-group-valued functors, much like in classical
bundle theory. Using this, we show that, under some mild requirements, these
gauge 2-groups possess a natural smooth structure. In the last section we
provide some explicit examples.Comment: 40 pages; v3: completely revised and extended, classification
corrected, name changed, to appear in Forum Mat
Depletion of T cells via Inducible Caspase 9 Increases Safety of Adoptive T-Cell Therapy Against Chronic Hepatitis B
T-cell therapy with T cells that are re-directed to hepatitis B virus (HBV)-infected cells by virus-specific receptors is a promising therapeutic approach for treatment of chronic hepatitis B and HBV-associated cancer. Due to the high number of target cells, however, side effects such as cytokine release syndrome or hepatotoxicity may limit safety. A safeguard mechanism, which allows depletion of transferred T cells on demand, would thus be an interesting means to increase confidence in this approach. In this study, T cells were generated by retroviral transduction to express either an HBV-specific chimeric antigen receptor (S-CAR) or T-cell receptor (TCR), and in addition either inducible caspase 9 (iC9) or herpes simplex virus thymidine kinase (HSV-TK) as a safety switch. Real-time cytotoxicity assays using HBV-replicating hepatoma cells as targets revealed that activation of both safety switches stopped cytotoxicity of S-CAR- or TCR-transduced T cells within less than one hour. In vivo, induction of iC9 led to a strong and rapid reduction of transferred S-CAR T cells adoptively transferred into AAV-HBV-infected immune incompetent mice. One to six hours after injection of the iC9 dimerizer, over 90% reduction of S-CAR T cells in the blood and the spleen and of over 99% in the liver was observed, thereby limiting hepatotoxicity and stopping cytokine secretion. Simultaneously, however, the antiviral effect of S-CAR T cells was diminished because remaining S-CAR T cells were mostly non-functional and could not be restimulated with HBsAg. A second induction of iC9 was only able to deplete T cells in the liver. In conclusion, T cells co-expressing iC9 and HBV-specific receptors efficiently recognize and kill HBV-replicating cells. Induction of T-cell death via iC9 proved to be an efficient means to deplete transferred T cells in vitro and in vivo containing unwanted hepatotoxicity
Concentration of rocuronium in cerebrospinal fluid of patients undergoing cerebral aneurysm clippingâ
Background. This study assessed the concentration of rocuronium in the cerebrospinal fluid (CSF) of patients undergoing cerebral aneurysm clipping, and investigated whether the mode of administration (single bolus vs continuous infusion) influenced the CSF concentration. Methods. Twenty patients with subarachnoid haemorrhage were randomly allocated to receive a bolus dose (bolus group), or a bolus followed by a continuous infusion of rocuronium (infusion group) (n=10 for each group). Arterial blood and ventricular CSF were sampled 2 h after the rocuronium bolus. Samples were analysed by liquid chromatography electrospray ionizationâtandem mass spectrometry. Results. Rocuronium could be detected in all the CSF samples. The mean (range) CSF concentration was 2.2 (0.9-4.6) ng ml-1 in the bolus group and 12.4 (2.4-34.6) ng ml-1 in the infusion group; P<0.01. Conclusions. This study demonstrated that rocuronium, normally not considered to cross the blood-brain barrier, is regularly found in the CSF of patients undergoing cerebral clipping; continuous infusion of the drug led to higher plasma and CSF concentrations than after a single bolus dose. Br J Anaesth 2004; 92: 419-2
Photosynthetic acclimation of Nannochloropsis oculata investigated by multi-wavelength chlorophyll fluorescence analysis
Multi-wavelength chlorophyll fluorescence analysis was utilised to examine the photosynthetic efficiency of the biofuel-producing alga Nannochloropsis oculata, grown under two light regimes; low (LL) and high (HL) irradiance levels. Wavelength dependency was evident in the functional absorption cross-section of Photosystem II (ÏII(λ)), absolute electron transfer rates (ETR(II)), and non-photochemical quenching (NPQ) of chlorophyll fluorescence in both HL and LL cells. While ÏII(λ) was not significantly different between the two growth conditions, HL cells upregulated ETR(II) 1.6-1.8-fold compared to LL cells, most significantly in the wavelength range of 440-540nm. This indicates preferential utilisation of blue-green light, a highly relevant spectral region for visible light in algal pond conditions. Under these conditions, the HL cells accumulated saturated fatty acids, whereas polyunsaturated fatty acids were more abundant in LL cells. This knowledge is of importance for the use of N. oculata for fatty acid production in the biofuel industry. © 2014 Elsevier Ltd
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