In vivo nuclear magnetic resonance imaging

A number of physiological changes have been demonstrated in bone, muscle and blood after exposure of humans and animals to microgravity. Determining mechanisms and the development of effective countermeasures for long duration space missions is an important NASA goal. The advent of tomographic nuclear magnetic resonance imaging (NMR or MRI) gives NASA a way to greatly extend early studies of this phenomena in ways not previously possible; NMR is also noninvasive and safe. NMR provides both superb anatomical images for volume assessments of individual organs and quantification of chemical/physical changes induced in the examined tissues. The feasibility of NMR as a tool for human physiological research as it is affected by microgravity is demonstrated. The animal studies employed the rear limb suspended rat as a model of mucle atrophy that results from microgravity. And bedrest of normal male subjects was used to simulate the effects of microgravity on bone and muscle

Local Casimir Energy For Solitons

Direct calculation of the one-loop contributions to the energy density of bosonic and supersymmetric phi-to-the-fourth kinks exhibits: (1) Local mode regularization. Requiring the mode density in the kink and the trivial sectors to be equal at each point in space yields the anomalous part of the energy density. (2) Phase space factorization. A striking position-momentum factorization for reflectionless potentials gives the non-anomalous energy density a simple relation to that for the bound state. For the supersymmetric kink, our expression for the energy density (both the anomalous and non-anomalous parts) agrees with the published central charge density, whose anomalous part we also compute directly by point-splitting regularization. Finally we show that, for a scalar field with arbitrary scalar background potential in one space dimension, point-splitting regularization implies local mode regularization of the Casimir energy density.Comment: 18 pages. Numerous new clarifications and additions, of which the most important may be the direct derivation of local mode regularization from point-splitting regularization for the bosonic kink in 1+1 dimension

Inhibition of EZH2 Ameliorates Lupusâ Like Disease in MRL/lpr Mice

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151823/1/art40931_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151823/2/art40931.pd

Mode regularization of the susy sphaleron and kink: zero modes and discrete gauge symmetry

To obtain the one-loop corrections to the mass of a kink by mode regularization, one may take one-half the result for the mass of a widely separated kink-antikink (or sphaleron) system, where the two bosonic zero modes count as two degrees of freedom, but the two fermionic zero modes as only one degree of freedom in the sums over modes. For a single kink, there is one bosonic zero mode degree of freedom, but it is necessary to average over four sets of fermionic boundary conditions in order (i) to preserve the fermionic Z$_2$ gauge invariance $\psi \to -\psi$, (ii) to satisfy the basic principle of mode regularization that the boundary conditions in the trivial and the kink sector should be the same, (iii) in order that the energy stored at the boundaries cancels and (iv) to avoid obtaining a finite, uniformly distributed energy which would violate cluster decomposition. The average number of fermionic zero-energy degrees of freedom in the presence of the kink is then indeed 1/2. For boundary conditions leading to only one fermionic zero-energy solution, the Z$_2$ gauge invariance identifies two seemingly distinct `vacua' as the same physical ground state, and the single fermionic zero-energy solution does not correspond to a degree of freedom. Other boundary conditions lead to two spatially separated $\omega \sim 0$ solutions, corresponding to one (spatially delocalized) degree of freedom. This nonlocality is consistent with the principle of cluster decomposition for correlators of observables.Comment: 32 pages, 5 figure

Self-DUal SU(3) Chern-Simons Higgs Systems

We explore self-dual Chern-Simons Higgs systems with the local $SU(3)$ and global $U(1)$ symmetries where the matter field lies in the adjoint representation. We show that there are three degenerate vacua of different symmetries and study the unbroken symmetry and particle spectrum in each vacuum. We classify the self-dual configurations into three types and study their properties.Comment: Columbia Preprint CU-TP-635, 19 page

Quantum Aspects of Supersymmetric Maxwell Chern-Simons Solitons

We study the various quantum aspects of the $N=2$ supersymmetric Maxwell Chern-Simons vortex systems. The fermion zero modes around the vortices will give rise the degenerate states of vortices. We analyze the angular momentum of these zero modes and apply the result to get the supermultiplet structures of the vortex. The leading quantum correction to the mass of the vortex coming from the mode fluctuations is also calculated using various methods depending on the value of the coefficient of the Chern-Simons term $\kappa$ to be zero, infinite and finite, separately. The mass correction is shown to vanish for all cases. Fermion numbers of vortices are also discussed.Comment: 40 pages, ReVTeX, HYUPT-94/04 SNUTP 94-6

Comparing the unmatched count technique and direct self-report for sensitive health-risk behaviors in HIV+ adults

Researchers often rely on self-report measures to assess sensitive health-risk behaviors in HIV+ individuals, yet the accuracy of self-report has been questioned, particularly when inquiring about behaviors that may be embarrassing, risky, and/or taboo. We compared an anonymous reporting method—the Unmatched Count Technique (UCT)—to direct self-report in order to assess reporting differences for several health-risk behaviors related to medication adherence and sexual risk. Contrary to hypotheses, the UCT only produced a significantly higher estimated base rate for one sensitive behavior: reporting medication adherence to one\u27s physician, which may have been contextually-primed by our study design. Our results suggest that anonymous reporting methods may not increase disclosure compared to direct self-report when assessing several health-risk behaviors in HIV+ research volunteers. However, our results also suggest that contextual factors should be considered and investigated further, as they may influence perception of sensitive behavior

Central charge and renormalization in supersymmetric theories with vortices

Some quantum features of vortices in supersymmetric theories in 1+2 dimensions are studied in a manifestly supersymmetric setting of the superfield formalism. A close examination of the supercurrent that accommodates the central charge and super-Poincare charges in a supermultiplet reveals that there is no genuine quantum anomaly in the supertrace identity and in the supercharge algebra, with the central-charge operator given by the bare Fayet-Iliopoulos term alone. The central charge and the vortex spectrum undergo renormalization on taking the expectation value of the central-charge operator. It is shown that the vortex spectrum is exactly determined at one loop while the spectrum of the elementary excitations receives higher-order corrections.Comment: 9 pages, revte