6,693 research outputs found
Interaction Correction of Conductivity Near a Ferromagnetic Quantum Critical Point
We calculate the temperature dependence of conductivity due to interaction
correction for a disordered itinerant electron system close to a ferromagnetic
quantum critical point which occurs due to a spin density wave instability. In
the quantum critical regime, the crossover between diffusive and ballistic
transport occurs at a temperature ,
where is the parameter associated with the Landau damping of the spin
fluctuations, is the impurity scattering time, and is the Fermi
energy. For a generic choice of parameters, is few orders of
magnitude smaller than the usual crossover scale . In the ballistic
quantum critical regime, the conductivity has a temperature
dependence, where is the dimensionality of the system. In the diffusive
quantum critical regime we get dependence in three dimensions, and
dependence in two dimensions. Away from the quantum critical regime
we recover the standard results for a good metal.Comment: 15 pages, 8 figure
Structural determination of archaeal UDP-N-acetylglucosamine 4-epimerase from Methanobrevibacter ruminantium M1 in complex with the bacterial cell wall intermediate UDP-N-acetylmuramic acid
The crystal structure of UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase; WbpP; EC 5.1.3.7), from the archaeal methanogen Methanobrevibacter ruminantium strain M1, was determined to a resolution of 1.65 Å. The structure, with a single monomer in the crystallographic asymmetric unit, contained a conserved N-terminal Rossmann fold for nucleotide binding and an active site positioned in the C-terminus. UDP-GlcNAc 4-epimerase is a member of the short-chain dehydrogenase/reductase superfamily, sharing sequence motifs and structural elements characteristic of this family of oxidoreductases and bacterial 4-epimerases. The protein was co-crystallized with coenzyme NADH and UDP-N-acetylmuramic acid, the latter an unintended inclusion and well known product of the bacterial enzyme MurB and a critical intermediate for bacterial cell wall synthesis. This is a non-native UDP sugar amongst archaea and was most likely incorporated from the Eschericha coli expression host during purification of the recombinant enzyme
Secular trends in under-reporting in young people
Original article can be found at: http://journals.cambridge.org/action/displayJournal?jid=BJN Copyright The Authors. DOI: 10.1079/BJN20041307National survey data show that reported energy intake has decreased in recent decades despite a rise in the prevalence of obesity. This disparity may be due to a secular increase in under-reporting or a quantitatively greater decrease in energy expenditure. This study examines the extent of under-reporting of energy intake in the National Diet and Nutrition Survey (NDNS) in young people aged 4–18 years in 1997 using published equations to calculate estimated energy requirements. It explores secular changes by comparison with the Diets of British School Children (DBSC) survey in 10–11- and 14–15-year-olds in 1983. In the NDNS, under-reporting (estimated energy requirements – energy intake) represented 21 % of energy needs in girls and 20 % in boys. The magnitude of under-reporting increased significantly with age (P<0·001) and was higher in overweight than lean individuals over 7 years of age. To compare reported energy intake in DBSC and NDNS, the estimated physical activity level from dietary records (dPAL=reported energy intake/predicted BMR) was calculated. If there were no under-reporting, dPAL would represent the subject's true activity level. However, dPAL from the NDNS was significantly lower than that from the DBSC by 8 % and 9 % in boys and girls for those aged 10–11 years, and by 14 % and 11 % for 14–15-year-olds respectively, reaching physiologically implausible levels in the 14–15-year-old girls (dPAL=1·17). If activity levels have remained constant between the two surveys, under-reporting has increased by 8–14 %. The evidence supports a secular trend towards increased under-reporting between the two surveys, but the precise magnitude cannot be quantified in the absence of historical measures of energy expenditure.Peer reviewe
Developing the evidence and associated service models to support older adults living with frailty to manage their pain and to reduce its impact on their lives: protocol for a mixed-method, co-design study (The POPPY Study)
Introduction The Pain in Older People with Frailty Study is a mixed-method, co-design study, which aims to develop the content, implementation strategies, service and professional guidance to support older adults with frailty to manage their pain.
Methods and analysis The study has four phases: Phase 1, research evidence and information synthesis from randomised controlled trials of multicomponent pain management programmes and psychological therapies for community-dwelling older adults. Phase 2, qualitative interviews with 30 community-dwelling older adults (≥75 years) living with frailty and persistent pain, including dyadic interviews with a spouse or unpaid carer. Phase 3, qualitative interviews with healthcare professionals (HCPs) working within various pain service types; 5–8 HCPs per service and up to 12 services including primary care, secondary care, tertiary centres and services with voluntary sector input. Phase 4, co-design workshops with older adults, HCPs and commissioners. Inclusion criteria (Phase 2): community-dwelling older adults (≥75 years) living with frailty and persistent pain. Exclusion criteria (Phase 2): care home residents, a dementia or cancer diagnosis. Cancer survivors, ≥5 years cancer free, and not undergoing active cancer treatment can participate. Analysis for Phase 1 will use narrative synthesis, Phase 2 will use grounded theory analysis and Phase 3 will use thematic analysis. Oversight is provided from a patient and public involvement group and an independent steering committee.
Ethics and dissemination The protocol was approved by Leeds-East Research Ethics Committee on 28 April 2022 (22/YH/0080). Consent is sought if an individual is willing to participate (Phases 2–4) and has capacity. Findings will be disseminated at conferences, in newsletters and journals and to local authorities and charities
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Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins.
Human gut Bacteroides use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other or the host for these critical resources. Unlike in Escherichia coli, transport loci for vitamin B12 (cobalamin) and other corrinoids in human gut Bacteroides are replete with conserved genes encoding proteins whose functions are unknown. Here we report that one of these proteins, BtuG, is a surface-exposed lipoprotein that is essential for efficient B12 transport in B. thetaiotaomicron. BtuG binds B12 with femtomolar affinity and can remove B12 from intrinsic factor, a critical B12 transport protein in humans. Our studies suggest that Bacteroides use surface-exposed lipoproteins not only for capturing polysaccharides, but also to acquire key vitamins in the gut
The effect of curvature and topology on membrane hydrodynamics
We study the mobility of extended objects (rods) on a spherical liquid-liquid
interface to show how this quantity is modified in a striking manner by both
the curvature and the topology of the interface. We present theoretical
calculations and experimental measurements of the interfacial fluid velocity
field around a moving rod bound to the crowded interface of a water-in-oil
droplet. By using different droplet sizes, membrane viscosities, and rod
lengths, we show that the viscosity mismatch between the interior and exterior
fluids leads to a suppression of the fluid flow on small droplets that cannot
be captured by the flat interface predictions.Comment: 4 pages, 3 figure
Energetic Instability Unjams Sand and Suspension
Jamming is a phenomenon occurring in systems as diverse as traffic, colloidal
suspensions and granular materials. A theory on the reversible elastic
deformation of jammed states is presented. First, an explicit granular
stress-strain relation is derived that captures many relevant features of sand,
including especially the Coulomb yield surface and a third-order jamming
transition. Then this approach is generalized, and employed to consider jammed
magneto- and electro-rheological fluids, again producing results that compare
well to experiments and simulations.Comment: 9 pages 2 fi
How should we interpret the two transport relaxation times in the cuprates ?
We observe that the appearance of two transport relaxation times in the
various transport coefficients of cuprate metals may be understood in terms of
scattering processes that discriminate between currents that are even, or odd
under the charge conjugation operator. We develop a transport equation that
illustrates these ideas and discuss its experimental and theoretical
consequences.Comment: 19 pages, RevTeX with 8 postscript figures included. To appear in
``Non Fermi Liquid Physics'', J. Phys:Cond. Matt. (1997
Encapsulation of phosphorus dopants in silicon for the fabrication of a quantum computer
The incorporation of phosphorus in silicon is studied by analyzing phosphorus
delta-doped layers using a combination of scanning tunneling microscopy,
secondary ion mass spectrometry and Hall effect measurements. The samples are
prepared by phosphine saturation dosing of a Si(100) surface at room
temperature, a critical annealing step to incorporate phosphorus atoms, and
subsequent epitaxial silicon overgrowth. We observe minimal dopant segregation
(5 nm), complete electrical activation at a silicon growth temperature of 250
degrees C and a high two-dimensional electron mobility of 100 cm2/Vs at a
temperature of 4.2 K. These results, along with preliminary studies aimed at
further minimizing dopant diffusion, bode well for the fabrication of
atomically precise dopant arrays in silicon such as those found in recent
solid-state quantum computer architectures.Comment: 3 pages, 4 figure
Predictive Inference Using Latent Variables With Covariates
Plausible values (PVs) are a standard multiple imputation tool for analysis of large education survey data, which measures latent proficiency variables. When latent proficiency is the dependent variable, we reconsider the standard institutionally generated PV methodology and find it applies with greater generality than shown previously. When latent proficiency is an independent variable, we show that the standard institutional PV methodology produces biased inference because the institutional conditioning model places restrictions on the form of the secondary analysts’ model. We offer an alternative approach that avoids these biases based on the mixed effects structural equations model of Schofield (Modeling measurement error when using cognitive test scores in social science research. Doctoral dissertation. Department of Statistics and Heinz College of Public Policy. Pittsburgh, PA: Carnegie Mellon University, 2008)
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