Lipid composition of human meibum

The structure and function of meibomian gland lipids in the tear film are highly complex. Evidence shows that the precorneal tear film consists of discrete layers: the inner mucin layer, the middle aqueous layer and the outer lipid layer. In this review we focus on the outer, biphasic lipid layer of the tear film which consists of a ‘thick’ outer, non-polar layer  and a ‘thin’ inner, polar layer. We discuss the main composition of the polar and non-polar lipids within meibum (wax esters, cholesteryl esters, mono-, di- and tri-acylglycerols, ceramides, phospholipids  et cetera). We address the composition of meibomian lipids in subjects suffering from various ocular diseases in comparison with the composition in healthy individuals. Further analysis is needed to determine whether a correlation exists between the etiology of various ocular diseases and the fluctuation on the lipids as well as to establish whether or not tear lipid analysis can be used as a diagnostic tool

EAGLE multi-object AO concept study for the E-ELT

EAGLE is the multi-object, spatially-resolved, near-IR spectrograph instrument concept for the E-ELT, relying on a distributed Adaptive Optics, so-called Multi Object Adaptive Optics. This paper presents the results of a phase A study. Using 84x84 actuator deformable mirrors, the performed analysis demonstrates that 6 laser guide stars and up to 5 natural guide stars of magnitude R<17, picked-up in a 7.3' diameter patrol field of view, allow us to obtain an overall performance in terms of Ensquared Energy of 35% in a 75x75 mas^2 spaxel at H band, whatever the target direction in the centred 5' science field for median seeing conditions. The computed sky coverage at galactic latitudes |b|~60 is close to 90%.Comment: 6 pages, to appear in the proceedings of the AO4ELT conference, held in Paris, 22-26 June 200

The role of primary healthcare professionals in oral cancer prevention and detection

AIM: To investigate current knowledge, examination habits and preventive practices of primary healthcare professionals in Scotland, with respect to oral cancer, and to determine any relevant training needs. SETTING: Primary care. METHOD: Questionnaires were sent to a random sample of 357 general medical practitioners (GMPs) and 331 dental practitioners throughout Scotland. Additionally, focus group research and interviews were conducted amongst primary healthcare team members. RESULTS: Whilst 58% of dental respondents reported examining regularly for signs of oral cancer, GMPs examined patients' mouths usually in response to a complaint of soreness. The majority of GMPs (85%) and dentists (63%) indicated that they felt less than confident in detecting oral cancer, with over 70% of GMPs identifying lack of training as an important barrier. Many practitioners were unclear concerning the relative importance of the presence of potentially malignant lesions in the oral cavity. A high proportion of the GMPs indicated that they should have a major role to play in oral cancer detection (66%) but many felt strongly that this should be primarily the remit of the dental team. CONCLUSION: The study revealed a need for continuing education programmes for primary care practitioners in oral cancer-related activities. This should aim to improve diagnostic skills and seek to increase practitioners' participation in preventive activities

Updated optical design and trade-off study for MOONS, the Multi-Object Optical and Near Infrared spectrometer for the VLT

This paper presents the latest optical design for the MOONS triple-arm spectrographs. MOONS will be a Multi-Object Optical and Near-infrared Spectrograph and will be installed on one of the European Southern Observatory (ESO) Very Large Telescopes (VLT). Included in this paper is a trade-off analysis of different types of collimators, cameras, dichroics and filters.Comment: 10 pages, 8 figures, 5 tables. Presented at SPIE Astronomical Telescope + Instrumentation 2014 (Ground-based and Airbone Instrumentation for Astronomy 5, 9147-84). To be published in Proceeding of SPIE Volume 914

Towards understanding and eliminating defects in additively manufactured CubeSat mirrors

Fabricating mirrors using additive manufacturing (AM; 3D printing) is a promising yet under-researched production route. There are several issues that need to be better understood before AM can be fully adopted to fabricate mirror substrates. A significant obstacle to AM adoption is the presence of porosity and the influence that has on the resultant optical proprieties. Several batches of high-silicon aluminium (AlSi10Mg) samples were created to investigate the relationships laser parameters, laser paths and build orientations have with the porosity. The results showed that eliminating defects relies on a complex interaction of the process parameters and material properties, with the residual heating from the laser proving to be a significant factor. In addition, the use of a hot isostatic press is investigated and some full prototypes of the Cassegrain CubeSat were produced