The evolution of the jet from Herbig Ae star HD 163296 from 1999 to 2011

Young A and B stars, the so-called Herbig Ae/Be stars (HAeBe), are surrounded by an active accretion disk and drive outflows. We study the jet HH 409, which is launched from the HAeBe star HD 163296, using new and archival observations from Chandra and HST/STIS. In X-rays we can show that the central source is not significantly extended. The approaching jet, but not the counter-jet, is detected in Ly alpha. In addition, there is red-shifted Ly alpha emission extended in the same direction as the jet, that is also absent in the counter-jet. We can rule out an accretion or disk-wind origin for this feature. In the optical we find the knots B and B2 in the counter-jet. Knot B has been observed previously, so we can derive its proper motion of 0.37+-0.01 arcsec/yr. Its electron density is 3000/cm^3, thus the cooling time scale is a few months only, so the knot needs to be reheated continuously. The shock speed derived from models of H alpha and forbidden emission lines (FELs) decreased from 50 km/s in 1999 to 30 km/s in 2011 because the shock front loses energy as it travels along the jet. Knot B2 is observed at a similar position in 2011 as knot B was in 1999, but shows a lower ionization fraction and higher mass loss rate, proving variations in the jet launching conditions.Comment: 14 pages, 8 figures, accepted by A&

Current-induced magnetic vortex core switching in a Permalloy nanodisk

We report on the switching of a magnetic vortex core in a sub-micron Permalloy disk, induced by a short current pulse applied in the film plane. Micromagnetic simulations including the adiabatic and non-adiabatic spin-torque terms are used to investigate the current-driven magnetization dynamics. We predict that a core reversal can be triggered by current bursts a tenth of a nanosecond long. The vortex core reversal process is found to be the same as when an external field pulse is applied. The control of a vortex core's orientation using current pulses introduces the technologically relevant possibility to address individual nanomagnets within dense arrays.Comment: 3 pages, 3 figure

Experimental probing of the anisotropy of the empty p states near the Fermi level in MgB2

We have studied the Boron K-edge in the superconductor MgB2 by electron energy loss spectroscopy (EELS) and experimentally resolved the empty p states at the Fermi level that have previously been observed within an energy window of 0.8eV by soft x-ray absorption spectroscopy. Using angular resolved EELS, we find that these states at the immediate edge onset have pxy character in agreement with predictions from first-principle electronic structure calculations.Comment: 15 pages, 5 figure

SBE13, a newly identified inhibitor of inactive polo-like kinase 1

Poster presentation at 5th German Conference on Cheminformatics: 23. CIC-Workshop Goslar, Germany. 8-10 November 2009 Protein kinases are important targets for drug development. The almost identical protein folding of kinases and the common co-substrate ATP leads to the problem of inhibitor selectivity. Type II inhibitors, targeting the inactive conformation of kinases, occupy a hydrophobic pocket with less conserved surrounding amino acids. Human polo-like kinase 1 (Plk1) represents a promising target for approaches to identify new therapeutic agents. Plk1 belongs to a family of highly conserved serine/threonine kinases, and is a key player in mitosis, where it modulates the spindle checkpoint at metaphase/anaphase transition. Plk1 is over-expressed in all today analyzed human tumors of different origin and serves as a negative prognostic marker in cancer patients. The newly identified inhibitor, SBE13, a vanillin derivative, targets Plk1 in its inactive conformation. This leads to selectivity within the Plk family and towards Aurora A. This selectivity can be explained by docking studies of SBE13 into the binding pocket of homology models of Plk1, Plk2 and Plk3 in their inactive conformation. SBE13 showed anti-proliferative effects in cancer cell lines of different origins with EC50 values between 5 microM and 39 microM and induced apoptosis. Increasing concentrations of SBE13 result in increasing amounts of cells in G2/M phase 13 hours after double thymidin block of HeLa cells. The kinase activity of Plk1 was inhibited with an IC50 of 200 pM. Taken together, we could show that carefully designed structure-based virtual screening is well-suited to identify selective type II kinase inhibitors targeting Plk1 as potential anti-cancer therapeutics

On the Integrability of Classical Ruijsenaars-Schneider Model of BC2BC_{2} Type

The problem of finding most general form of the classical integrable relativistic models of many-body interaction of the $BC_{n}$ type is considered. In the simplest nontrivial case of $n=2$,the extra integral of motion is presented in explicit form within the ansatz similar to the nonrelativistic Calogero-Moser models. The resulting Hamiltonian has been found by solving the set of two functional equations.Comment: 10 pages, LaTeX2e, no figure

Searching for galaxy clusters using the aperture mass statistics in 50 VLT fields

Application of the aperture mass (Map-) statistics provides a weak lensing method for the detection of cluster-sized dark matter halos. We present a new aperture filter function and maximise the effectiveness of the Map-statistics to detect cluster-sized halos using analytical models. We then use weak lensing mock catalogues generated from ray-tracing through N-body simulations, to analyse the effect of image treatment on the expected number density of halos. Using the Map-statistics, the aperture radius is typically several arcminutes, hence the aperture often lies partly outside a data field, consequently the signal-to-noise ratio of a halo detection decreases. We study these border effects analytically and by using mock catalogues. We find that the expected number density of halos decreases by a factor of two if the size of a field is comparable to the diameter of the aperture used. We finally report on the results of a weak lensing cluster search applying the Map-statistics to 50 randomly selected fields which were observed with FORS1 at the VLT. Altogether the 50 VLT fields cover an area of 0.64 square degrees. The I-band images were taken under excellent seeing conditions (average seeing 0.6 arcsec.) which results in a high number density of galaxies used for the weak lensing analysis (26/sq.arcmin). In five of the VLT fields, we detect a significant Map-signal which coincides with an overdensity of the light distribution. These detections are thus excellent candidates for shear-selected clusters.Comment: 23 pages, 5 tables, 24 figures, published in A&A, Sect. 3.5 and 7 are changed or altered; Fig. 11 is change

Beeping a Maximal Independent Set

We consider the problem of computing a maximal independent set (MIS) in an extremely harsh broadcast model that relies only on carrier sensing. The model consists of an anonymous broadcast network in which nodes have no knowledge about the topology of the network or even an upper bound on its size. Furthermore, it is assumed that an adversary chooses at which time slot each node wakes up. At each time slot a node can either beep, that is, emit a signal, or be silent. At a particular time slot, beeping nodes receive no feedback, while silent nodes can only differentiate between none of its neighbors beeping, or at least one of its neighbors beeping. We start by proving a lower bound that shows that in this model, it is not possible to locally converge to an MIS in sub-polynomial time. We then study four different relaxations of the model which allow us to circumvent the lower bound and find an MIS in polylogarithmic time. First, we show that if a polynomial upper bound on the network size is known, it is possible to find an MIS in O(log^3 n) time. Second, if we assume sleeping nodes are awoken by neighboring beeps, then we can also find an MIS in O(log^3 n) time. Third, if in addition to this wakeup assumption we allow sender-side collision detection, that is, beeping nodes can distinguish whether at least one neighboring node is beeping concurrently or not, we can find an MIS in O(log^2 n) time. Finally, if instead we endow nodes with synchronous clocks, it is also possible to find an MIS in O(log^2 n) time.Comment: arXiv admin note: substantial text overlap with arXiv:1108.192

Small atom diffusion and breakdown of the Stokes–Einstein relation in the supercooled liquid state of the Zr46.7Ti8.3Cu7.5Ni10Be27.5 alloy

Be diffusivity data in the bulk metallic glass forming alloy Zr46.7Ti8.3Cu7.5Ni10Be27.5 are reported for temperatures between 530 and 710 K, extending 85 K into the supercooled liquid state of the alloy. At the glass transition temperature Tg, a change in temperature dependence of the data is observed, and above Tg the diffusivity increases more quickly with temperature than below. The data in the supercooled liquid can be described by a modified Arrhenius expression based on a diffusion mechanism suggested earlier. The comparison with viscosity data in the supercooled liquid state of Zr46.7Ti8.3Cu7.5Ni10Be27.5 reveals a breakdown of the Stokes–Einstein relation, indicating a cooperative diffusion mechanism in the supercooled liquid state of Zr46.7Ti8.3Cu7.5Ni10Be27.5