1,474 research outputs found
Cosmology with Weak Lensing Surveys
Weak gravitational lensing surveys measure the distortion of the image of
distant sources due to the deflections of light rays by the fluctuations of the
gravitational potential along the line of sight. Since they probe the
non-linear matter power spectrum itself at medium redshift such surveys are
complimentary to both galaxy surveys (which follow stellar light) and cosmic
microwave background observations (which probe the linear regime at high
redshift). Ongoing CMB experiments such as WMAP and the future Planck satellite
mission will measure the standard cosmological parameters with unprecedented
accuracy. The focus of attention will then shift to understanding the nature of
dark matter and vacuum energy: several recent studies suggest that lensing is
the best method for constraining the dark energy equation of state. During the
next 5 year period ongoing and future weak lensing surveys such as the Joint
Dark Energy Mission (JDEM, e.g. SNAP) or the Large-aperture Synoptic Survey
Telescope (LSST) will play a major role in advancing our understanding of the
universe in this direction. In this review article we describe various aspects
of weak lensing surveys and how they can help us in understanding our universe.Comment: 15 pages, review article to appear in 2005 Triennial Issue of Phil.
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Nanoscale patterning of self-assembled monolayer (SAM)-functionalised substrates with single molecule contact printing
Defined arrangements of individual molecules are covalenty connected ("printed") onto SAM-functionalised gold substrates with nanometer resolution. Substrates were initially pre-functionlised by coating with 3,3′-dithiodipropionic acid (DTPA) to form a self-assembled monolayer (SAM), which was characterised by atomic force microscopy (AFM), contact angle goniometry, cyclic voltammetry and surface plasmon resonance (SPR) spectroscopy. Pre-defined "ink" patterns displayed on DNA origami-based single-use carriers ("stamp") were covalently conjugated to the SAM using 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (EDC) and N-hydroxy-succinimide (NHS). These anchor points were used to create nanometer-precise single-molecule arrays, here with complementary DNA and streptavidin. Sequential steps of the printing process were evaluated by AFM and SPR spectroscopy. It was shown that 30% of the detected arrangements closely match the expected length distribution of designed patterns, whereas another 40% exhibit error within the range of only 1 streptavidin molecule. SPR results indicate that imposing a defined separation between molecular anchor points within the pattern through this printing process enhances the efficiency for association of specific binding partners for systems with high sterical hindrance. This study expands upon earlier findings where geometrical information was conserved by the application of DNA nanostructures, by establishing a generalisable strategy which is universally applicable to nearly any type of prefunctionalised substrate such as metals, plastics, silicates, ITO or 2D materials
Large time wellposdness to the 3-D Capillary-Gravity Waves in the long wave regime
In the regime of weakly transverse long waves, given long-wave initial data,
we prove that the nondimensionalized water wave system in an infinite strip
under influence of gravity and surface tension on the upper free interface has
a unique solution on [0,{T}/\eps] for some \eps independent of constant
We shall prove in the subsequent paper \cite{MZZ2} that on the same time
interval, these solutions can be accurately approximated by sums of solutions
of two decoupled Kadomtsev-Petviashvili (KP) equations.Comment: Split the original paper(The long wave approximation to the 3-D
capillary-gravity waves) into two parts, this is the first on
Detection methods for non-Gaussian gravitational wave stochastic backgrounds
We address the issue of finding an optimal detection method for a
discontinuous or intermittent gravitational wave stochastic background. Such a
signal might sound something like popcorn popping. We derive an appropriate
version of the maximum likelihood detection statistic, and compare its
performance to that of the standard cross-correlation statistic both
analytically and with Monte Carlo simulations. The maximum likelihood statistic
performs better than the cross-correlation statistic when the background is
sufficiently non-Gaussian. For both ground and space based detectors, this
results in a gain factor, ranging roughly from 1 to 3, in the minimum
gravitational-wave energy density necessary for detection, depending on the
duty cycle of the background. Our analysis is exploratory, as we assume that
the time structure of the events cannot be resolved, and we assume white,
Gaussian noise in two collocated, aligned detectors. Before this detection
method can be used in practice with real detector data, further work is
required to generalize our analysis to accommodate separated, misaligned
detectors with realistic, colored, non-Gaussian noise.Comment: 25 pages, 12 figures, submitted to physical review D, added revisions
in response to reviewers comment
BDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behaviour
The physiology of brain-derived neurotrophic factor signaling in enkephalinergic striatopallidal neurons is poorly understood. Changes in cortical Bdnf expression levels, and/or impairment in brain-derived neurotrophic factor anterograde transport induced by mutant huntingtin (mHdh) are believed to cause striatopallidal neuron vulnerability in early-stage Huntington’s disease. Although several studies have confirmed a link between altered cortical brain-derived neurotrophic factor signaling and striatal vulnerability, it is not known whether the effects are mediated via the brain-derived neurotrophic factor receptor TrkB, and whether they are direct or indirect. Using a novel genetic mouse model, here, we show that selective removal of brain-derived neurotrophic factor–TrkB signaling from enkephalinergic striatal targets unexpectedly leads to spontaneous and drug-induced hyperlocomotion. This is associated with dopamine D2 receptor-dependent increased striatal protein kinase C and MAP kinase activation, resulting in altered intrinsic activation of striatal enkephalinergic neurons. Therefore, brain-derived neurotrophic factor/TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior by modulating neuronal activity in response to excitatory input through the protein kinase C/MAP kinase pathway
Testing Scalar-Tensor Gravity Using Space Gravitational-Wave Interferometers
We calculate the bounds which could be placed on scalar-tensor theories of
gravity of the Jordan, Fierz, Brans and Dicke type by measurements of
gravitational waveforms from neutron stars (NS) spiralling into massive black
holes (MBH) using LISA, the proposed space laser interferometric observatory.
Such observations may yield significantly more stringent bounds on the
Brans-Dicke coupling parameter \omega than are achievable from solar system or
binary pulsar measurements. For NS-MBH inspirals, dipole gravitational
radiation modifies the inspiral and generates an additional contribution to the
phase evolution of the emitted gravitational waveform. Bounds on \omega can
therefore be found by using the technique of matched filtering. We compute the
Fisher information matrix for a waveform accurate to second post-Newtonian
order, including the effect of dipole radiation, filtered using a currently
modeled noise curve for LISA, and determine the bounds on \omega for several
different NS-MBH canonical systems. For example, observations of a 1.4 solar
mass NS inspiralling to a 1000 solar mass MBH with a signal-to-noise ratio of
10 could yield a bound of \omega > 240,000, substantially greater than the
current experimental bound of \omega > 3000.Comment: 18 pages, 4 figures, 1 table; to be submitted to Phys. Rev.
Decoherence in trapped ions due to polarization of the residual background gas
We investigate the mechanism of damping and heating of trapped ions
associated with the polarization of the residual background gas induced by the
oscillating ions themselves. Reasoning by analogy with the physics of surface
electrons in liquid helium, we demonstrate that the decay of Rabi oscillations
observed in experiments on 9Be+ can be attributed to the polarization phenomena
investigated here. The measured sensitivity of the damping of Rabi oscillations
with respect to the vibrational quantum number of a trapped ion is also
predicted in our polarization model.Comment: 26 pdf pages with 5 figures, http://www.df.ufscar.br/~quantum
Ideal Gases in Time-Dependent Traps
We investigate theoretically the properties of an ideal trapped gas in a
time-dependent harmonic potential. Using a scaling formalism, we are able to
present simple analytical results for two important classes of experiments:
free expansion of the gas upon release of the trap; and the response of the gas
to a harmonic modulation of the trapping potential is investigated. We present
specific results relevant to current experiments on trapped Fermions.Comment: 5 pages, 3 eps figure
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