72 research outputs found
Personal and situational determinants of personality responses: A partial reanalysis and reinterpretation of the Schmit et al. (1995) data
Observations of Coronal Mass Ejections with the Coronal Multichannel Polarimeter
The Coronal Multichannel Polarimeter (CoMP) measures not only the
polarization of coronal emission, but also the full radiance profiles of
coronal emission lines. For the first time, CoMP observations provide
high-cadence image sequences of the coronal line intensity, Doppler shift and
line width simultaneously in a large field of view. By studying the Doppler
shift and line width we may explore more of the physical processes of CME
initiation and propagation. Here we identify a list of CMEs observed by CoMP
and present the first results of these observations. Our preliminary analysis
shows that CMEs are usually associated with greatly increased Doppler shift and
enhanced line width. These new observations provide not only valuable
information to constrain CME models and probe various processes during the
initial propagation of CMEs in the low corona, but also offer a possible
cost-effective and low-risk means of space weather monitoring.Comment: 6 figures. Will appear in the special issue of Coronal Magnetism,
Sol. Phy
Polarimetric Properties of Flux-Ropes and Sheared Arcades in Coronal Prominence Cavities
The coronal magnetic field is the primary driver of solar dynamic events.
Linear and circular polarization signals of certain infrared coronal emission
lines contain information about the magnetic field, and to access this
information, either a forward or an inversion method must be used. We study
three coronal magnetic configurations that are applicable to polar-crown
filament cavities by doing forward calculations to produce synthetic
polarization data. We analyze these forward data to determine the
distinguishing characteristics of each model. We conclude that it is possible
to distinguish between cylindrical flux ropes, spheromak flux ropes, and
sheared arcades using coronal polarization measurements. If one of these models
is found to be consistent with observational measurements, it will mean
positive identification of the magnetic morphology that surrounds certain
quiescent filaments, which will lead to a greater understanding of how they
form and why they erupt.Comment: 22 pages, 8 figures, Solar Physics topical issue: Coronal Magnetis
Ethnic and gender differences in applicants' decision-making processes: An application of the theory of reasoned action
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HIV-1 drug-resistance patterns among patients on failing treatment in a large number of European countries
Background: Information about patterns of HIV-1 drug resistance among treatment-exposed patients is crucial for the development of novel effective drugs. Currently no system exists that monitors patterns of resistance in patients failing therapy. Methods: The study included 1,988 HIV-1 sequences from patients experiencing therapy failure collected between 2000 and 2004 in 15 European countries. Genotypic resistance was interpreted using the ANRS algorithm. Phenotypic resistance was predicted using the Virco geno- to phenotype system. Results: 80.7% of the sequences included at least one drug-resistance mutation. Mutations were found for NRTIs (73.5%), NNRTIs (48.5%), and protease inhibitors (35.8%). Ninety percent of sequences with genotypic resistance harbored M184V, M41L, K103N, D67N, and/or T215Y. Among NRTIs, resistance was most frequently predicted for lamivudine. About half of all sequences had reduced susceptibility for NNRTIs. Resistance to most boosted protease inhibitors was found in < 25%. No sequence had resistance to all currently available drugs. Conclusion: Levels of resistance among patients with therapy failure were high. The patterns of resistance reflect resistance to drugs available for a longer time. Fully suppressive regimens can be designed even for the most mutated HIV because boosted protease inhibitors have remained active against most circulating viruses and new drug classes have become available.</p
HIV-1 drug-resistance patterns among patients on failing treatment in a large number of European countries
Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study
PURPOSE: Resistin, a novel pro-inflammatory protein implicated in inflammatory processes, has been suggested to play a role in colorectal development. However, evidence from observational studies has been inconsistent. Mendelian randomization may be a complementary method to examine this association. METHODS: We conducted a two-sample Mendelian randomization to estimate the association between genetically determined circulating resistin concentrations and risk of colorectal cancer (CRC). Protein quantitative trait loci (pQTLs) from the SCALLOP consortium were used as instrumental variables (IVs) for resistin. CRC genetic summary data was obtained from GECCO/CORECT/CCFR (the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry), and FinnGen (Finland Biobank). The inverse variance weighted method (IVW) was applied in the main analysis, and other robust methods were used as sensitivity analyses. Estimates for the association from the two data sources were then pooled using a meta-analysis approach. RESULTS: Thirteen pQTLs were identified as IVs explaining together 7.80% of interindividual variation in circulating resistin concentrations. Based on MR analyses, genetically determined circulating resistin concentrations were not associated with incident CRC (pooled-IVW-OR per standard deviation of resistin, 1.01; 95% CI 0.96, 1.06; p = 0.67. Restricting the analyses to using IVs within or proximal to the resistin-encoding gene (cis-IVs), or to IVs located elsewhere in the genome (trans-IVs) provided similar results. The association was not altered when stratified by sex or CRC subsites. CONCLUSIONS: We found no evidence of a relationship between genetically determined circulating resistin concentrations and risk of CRC
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice
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