Recent global decline in endorheic basin water storages

Endorheic (hydrologically landlocked) basins spatially concur with arid/semi-arid climates. Given limited precipitation but high potential evaporation, their water storage is vulnerable to subtle flux perturbations, which are exacerbated by global warming and human activities. Increasing regional evidence suggests a probably recent net decline in endorheic water storage, but this remains unquantified at a global scale. By integrating satellite observations and hydrological modelling, we reveal that during 2002–2016 the global endorheic system experienced a widespread water loss of about 106.3 Gt yr−1, attributed to comparable losses in surface water, soil moisture and groundwater. This decadal decline, disparate from water storage fluctuations in exorheic basins, appears less sensitive to El Niño–Southern Oscillation-driven climate variability, which implies a possible response to longer-term climate conditions and human water management. In the mass-conserved hydrosphere, such an endorheic water loss not only exacerbates local water stress, but also imposes excess water on exorheic basins, leading to a potential sea level rise that matches the contribution of nearly half of the land glacier retreat (excluding Greenland and Antarctica). Given these dual ramifications, we suggest the necessity for long-term monitoring of water storage variation in the global endorheic system and the inclusion of its net contribution to future sea level budgeting

SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency.

Natural killer (NK) cells recognize virally infected cells and tumors. NK cell function depends on balanced signaling from activating receptors, recognizing products from tumors or viruses, and inhibitory receptors (such as KIR/Ly49), which recognize major histocompatibility complex class I (MHC-I) molecules. KIR/Ly49 signaling preserves tolerance to self but also conveys reactivity toward MHC-I-low target cells in a process known as NK cell education. Here, we found that NK cell tolerance and education were determined by the subcellular localization of the tyrosine phosphatase SHP-1. In mice lacking MHC-I molecules, uneducated, self-tolerant Ly49A <sup>+</sup> NK cells showed accumulation of SHP-1 in the activating immune synapse, where it colocalized with F-actin and the signaling adaptor protein SLP-76. Education of Ly49A <sup>+</sup> NK cells by the MHC-I molecule H2D <sup>d</sup> led to reduced synaptic accumulation of SHP-1, accompanied by augmented signaling from activating receptors. Education was also linked to reduced transcription of Ptpn6, which encodes SHP-1. Moreover, synaptic SHP-1 accumulation was reduced in NK cells carrying the H2D <sup>d</sup> -educated receptor Ly49G2 but not in those carrying the noneducating receptor Ly49I. Colocalization of Ly49A and SHP-1 outside of the synapse was more frequent in educated compared with uneducated NK cells, suggesting a role for Ly49A in preventing synaptic SHP-1 accumulation in NK cell education. Thus, distinct patterning of SHP-1 in the activating NK cell synapse may determine NK cell tolerance

Bacon and Bergson on Time and Motion

he bearing of Bergsonian thought on Bacon’s paintings has become apparent as a result of Deleuze’s study, Francis Bacon: Logique de la sensation (1981). But aside from Deleuze’s application, there is a lot to recommend constructing a parallel between Bacon and Bergson as figures in their own right. This article explores Bergson’s approaches to temporality and the idea of immediate experience, and applies these to Bacon’s oeuvre, especially with respect to the artist’s antithetical views about an interpretation of narrative, the violence in his work and the phenomenology of the body

Nonlinear Dynamics of Magnetic Bearing Systems

Copyright © 2008 by SAGE PublicationsMagnetic bearings use magnetic forces to support various machine components. Because of the non-contact nature of this type of suspension, magnetic bearing technology offers a number of significant advantages over conventional bearings, such as rolling element and fluid film bearings. An active magnetic bearing basically consists of an electromagnetic actuator, position sensors, power amplifiers, and a feedback controller. All of these components are characterized by nonlinear behavior and therefore the entire system is inherently nonlinear. However, in simulations of the dynamic behavior of magnetic bearing systems, the nonlinearities are usually neglected to simplify the analysis and only linear models are used. Moreover, many control techniques currently used in magnetic bearing systems are generally designed by ignoring nonlinear effects. The main reason for simplification is the intractability of the complexity of the actual model. In fact, the inherent nonlinear properties of magnetic bearing systems can lead to dynamic behavior of a magnetically suspended rotor that is distinctly different from that predicted using a simple linearized model. Therefore, the nonlinearities should be taken into account. This literature review is focused on the nonlinear dynamics of magnetic bearing systems and it provides background information on analytical methods, nonlinear vibrations resulting from a rotor contacting auxiliary bearings, and other active topics of research involving the nonlinear properties of magnetic bearing systems, such as nonlinear self-sensing magnetic bearings and nonlinear control of magnetic bearings. The review concludes with a brief discussion on current and possible future directions for research on the nonlinear dynamics of magnetic bearing systems.J.C. Ji, Colin H. Hansen and Anthony C. Zande