Relevant prior knowledge moderates the effect of elaboration during small group discussion on academic achievement

This study set out to test whether relevant prior knowledge would moderate a positive effect on academic achievement of elaboration during small-group discussion. In a 2 × 2 experimental design, 66 undergraduate students observed a video showing a small-group problem-based discussion about thunder and lightning. In the video, a teacher asked questions to the observing participants. Participants either elaborated by responding to these questions, or did not elaborate, but completed a

Landscapes of Internment: British Prisoner of War Camps and the Memory of the First World War

This article has been accepted for publication and will appear in a revised form, subsequent to peer review and/or editorial input by Cambridge University Press, in Journal of British Studies published by Cambridge University Press. Copyright Cambridge University Press.During the First World War, all the belligerent powers interned both civilian and military prisoners. In Britain alone, over 100,000 people were held behind barbed wire. Despite the scale of this enterprise, interment barely features in Britain's First World War memory culture. By exploring the place of prisoner of war camps within the "militarized environment" of the home front, this article demonstrates the centrality of internment to local wartime experiences. Being forced to share the same environment meant that both British civilians and German prisoners clashed over access to resources, roads and the surrounding landscape. As the article contends, it was only when the British started to employ the prisoners on environmental improvement measures, such as land drainage or river clearance projects, that relations gradually improved. With the end of the war and closure of the camps, however, these deep entanglements were quickly forgotten. Instead of commemorating the complexities of the conflict, Britain's memory culture focused on more comfortable narratives; British military "sacrifice" on the Western Front quickly replaced any discussion of the internment of the "enemy" at home

Methods of model reduction for large-scale biological systems: a survey of current methods and trends

Complex models of biochemical reaction systems have become increasingly common in the systems biology literature. The complexity of such models can present a number of obstacles for their practical use, often making problems difficult to intuit or computationally intractable. Methods of model reduction can be employed to alleviate the issue of complexity by seeking to eliminate those portions of a reaction network that have little or no effect upon the outcomes of interest, hence yielding simplified systems that retain an accurate predictive capacity. This review paper seeks to provide a brief overview of a range of such methods and their application in the context of biochemical reaction network models. To achieve this, we provide a brief mathematical account of the main methods including timescale exploitation approaches, reduction via sensitivity analysis, optimisation methods, lumping, and singular value decomposition-based approaches. Methods are reviewed in the context of large-scale systems biology type models, and future areas of research are briefly discussed

Mathematical modeling of intracellular signaling pathways

Dynamic modeling and simulation of signal transduction pathways is an important topic in systems biology and is obtaining growing attention from researchers with experimental or theoretical background. Here we review attempts to analyze and model specific signaling systems. We review the structure of recurrent building blocks of signaling pathways and their integration into more comprehensive models, which enables the understanding of complex cellular processes. The variety of mechanisms found and modeling techniques used are illustrated with models of different signaling pathways. Focusing on the close interplay between experimental investigation of pathways and the mathematical representations of cellular dynamics, we discuss challenges and perspectives that emerge in studies of signaling systems

In England kriegsgefangen!; meine Erlebnisse in dem Gefangenenlager Dorchester

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