Sun direction detection system

One of the detectors is an illumination detector consisting of two spaced apart elongated strips with a strip of cadmium sulphide (Cds) deposited therebetween. Whenever the line image impinges the CdS strip, the resistance between the two other strips is relatively low, while being high when the line image is outside the field of view of the illumination detector. Also included is a sun angle detector which consists of a vapor deposited resistor strip connected at one end to plus 10v and at the other end to minus 10v. Spaced apart from the resistor strip is an elongated strip of low resistance material acting as an output strip, with a CdS strip between the two strips. When the line image is within the field of view of the sun angle detector, the output voltage at the output strip depends on the position of the line image across the sun angle detector

Inflatable stretcher to transport patients

Inflatable plastic bag inside strong, inflexible outer bag facilitates emergency transport of seriously burned or disabled patients. When the bag is inflated the patient is completely immobilized and cushioned from external shock. Air for breathing, temperature controls and communications may be provided by appropriate plug-in connections

Isotopic enrichment of nitrogen in the photolysis of NO

Isotopic enrichment of nitrogen in photolysis of N

Apollo applications program data archives

Apollo applications program data archives to collect, store, retrieve, and distribute experiments-related dat

Coordinate regulation of the WNT and Hippo pathways by the novel Ras effector NORE1A.

Ras is the most frequently activated oncogene found in human cancer, but its mechanisms of action remain only partially understood. Ras activates multiple signaling pathways in order to promote transformation, but can also exhibit a potent ability to induce growth arrest and death. NORE1A (RASSF5) is a direct Ras effector that acts as a tumor suppressor promoting senescence and apoptosis. Its expression is frequently lost in human tumors and its mechanism of action remains unclear. Here I show that NORE1A forms a direct, Ras regulated, complex with β-TrCP, the substrate recognition component of the SCF-β-TrCP ubiquitin ligase complex. NORE1A also binds GSK-3β resulting in enhanced kinase activity, which is required to phosphorylate SCF-β-TrCP substrates before their recognition by the ubiquitin ligase complex. Thus, by acting as a scaffold between β-TrCP and GSK-3β, NORE1A allows for Ras to both qualitatively and quantitatively enhance the proteosomal degradation of SCF-β-TrCP targets, such as β- catenin and TAZ. However, this control is substrate specific, as IκB, another substrate of SCF-β-TrCP, is not sensitive to NORE1A promoted degradation. Thus, I identify a completely novel signaling mechanism for Ras that allows the coordinate regulation of the Wnt/β-catenin and Hippo pathways, and potentially multiple other SCF-β-TrCP targets. The mechanism is frequently impaired in tumors by loss of NORE1A expression and provides an explanation for the observation that β-TrCP can act as a tumor suppressor or an oncogene in different cell systems

The Justin Miller Prize

The Justin Miller Priz