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Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene.
Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene. The overexpression induces genomic instability and blocks differentiation, likely mediated in part by enhanced expression of the stem cell gene SOX2. GLI2 also induces transforming growth factor (TGF)B1-dependent transdifferentiation of foreskin and tongue, but not gingival fibroblasts into myofibroblasts, creating an environment permissive for invasion by keratinocytes, which are in various stages of differentiation having downregulated GLI2. Thus, upregulated GLI2 expression is sufficient to induce a number of the acquired characteristics of tumor cells; however, the stroma, in a tissue-specific manner, determines whether certain GLI2 oncogenic traits are expressed
Bounds for State Degeneracies in 2D Conformal Field Theory
In this note we explore the application of modular invariance in
2-dimensional CFT to derive universal bounds for quantities describing certain
state degeneracies, such as the thermodynamic entropy, or the number of
marginal operators. We show that the entropy at inverse temperature 2 pi
satisfies a universal lower bound, and we enumerate the principal obstacles to
deriving upper bounds on entropies or quantum mechanical degeneracies for fully
general CFTs. We then restrict our attention to infrared stable CFT with
moderately low central charge, in addition to the usual assumptions of modular
invariance, unitarity and discrete operator spectrum. For CFT in the range
c_left + c_right < 48 with no relevant operators, we are able to prove an upper
bound on the thermodynamic entropy at inverse temperature 2 pi. Under the same
conditions we also prove that a CFT can have a number of marginal deformations
no greater than ((c_left + c_right) / (48 - c_left - c_right)) e^(4 Pi) - 2.Comment: 23 pages, LaTeX, minor change
An accurate test for homogeneity of odds ratios based on Cochran's Q-statistic
Background: A frequently used statistic for testing homogeneity in a meta-analysis of K independent studies is Cochran's Q. For a standard test of homogeneity the Q statistic is referred to a chi-square distribution with K - 1 degrees of freedom. For the situation in which the effects of the studies are logarithms of odds ratios, the chi-square distribution is much too conservative for moderate size studies, although it may be asymptotically correct as the individual studies become large. Methods: Using a mixture of theoretical results and simulations, we provide formulas to estimate the shape and scale parameters of a gamma distribution to t the distribution of Q. Results: Simulation studies show that the gamma distribution is a good approximation to the distribution for Q. Conclusions: : Use of the gamma distribution instead of the chi-square distribution for Q should eliminate inaccurate inferences in assessing homogeneity in a meta-analysis. (A computer program for implementing this test is provided.) This hypothesis test is competitive with the Breslow-Day test both in accuracy of level and in power
Manganese as a Probe of Fungal Degradation of Wood
Transition state metals, such as manganese (Mn) and iron (Fe), have been reported to be involved in fungal degradation of wood (Ellis, 1959; Shortl
Evidence of meansâend behavior in Asian elephants (Elephas maximus)
The present study explores to what extent Asian elephants show âmeansâendâ behavior. We used captive Asian elephants (NÂ =Â 2) to conduct four variations of the Piagetian âsupportâ problem, which involves a goal object that is out of reach, but rests on a support within reach. In the first condition, elephants were simultaneously presented with two identical trays serving as the âsupportâ, with the bait on one tray and the other tray left empty. In the next two conditions, the bait was placed on one tray, while additional bait was placed beside the other tray. In the last condition, both trays contained bait, but one of the trays had a small gap which prevented the elephants from reaching the reward. Subjects were required to choose and pull either tray with their trunk and to obtain the bait (i.e. goal). Results showed that one elephant performed all of the support problems significantly above chance after several sessions, suggesting that the elephant was capable of understanding that pulling the tray was the âmeansâ for achieving the âendâ of obtaining the bait. This study showed that elephants show meansâend behavior when subjected to a Piagetian âsupportâ task, and indicates that such goal-directed behavior occurs in species other than primates
Self-reflection and academic performance: is there a relationship?
The purposes of the present study were two-fold: first, to evaluate whether reflection journal writing was effective in promoting self-reflection and learning, and whether students become better at self-reflection if they engage continuously in reflection journal writing. To that end, the reflection journals of 690 first-year applied science students at a local polytechnic were studied by means of an automated coding procedures using software. Data was collected twice, once at the beginning and again towards the end of an academic year. Outcomes of the textual content analyses revealed that students reflected on both the process and contents of their learning: critical review of past learning experiences, learning strategies and summaries of what was learned. Correlational analyses showed weak to moderate inter-relationship
Hierarchical Equations of Motion Approach to Quantum Thermodynamics
We present a theoretical framework to investigate quantum thermodynamic
processes under non-Markovian system-bath interactions on the basis of the
hierarchical equations of motion (HEOM) approach, which is convenient to carry
out numerically "exact" calculations. This formalism is valuable because it can
be used to treat not only strong system-bath coupling but also system-bath
correlation or entanglement, which will be essential to characterize the heat
transport between the system and quantum heat baths. Using this formalism, we
demonstrated an importance of the thermodynamic effect from the tri-partite
correlations (TPC) for a two-level heat transfer model and a three-level
autonomous heat engine model under the conditions that the conventional quantum
master equation approaches are failed. Our numerical calculations show that TPC
contributions, which distinguish the heat current from the energy current, have
to be take into account to satisfy the thermodynamic laws.Comment: 9 pages, 4 figures. As a chapter of: F. Binder, L. A. Correa, C.
Gogolin, J. Anders, and G. Adesso (eds.), "Thermodynamics in the quantum
regime - Recent Progress and Outlook", (Springer International Publishing
High Speed Two-Photon Imaging of Calcium Dynamics in Dendritic Spines: Consequences for Spine Calcium Kinetics and Buffer Capacity
Rapid calcium concentration changes in postsynaptic structures are crucial for synaptic plasticity. Thus far, the determinants of postsynaptic calcium dynamics have been studied predominantly based on the decay kinetics of calcium transients. Calcium rise times in spines in response to single action potentials (AP) are almost never measured due to technical limitations, but they could be crucial for synaptic plasticity. With high-speed, precisely-targeted, two-photon point imaging we measured both calcium rise and decay kinetics in spines and secondary dendrites in neocortical pyramidal neurons. We found that both rise and decay kinetics of changes in calcium-indicator fluorescence are about twice as fast in spines. During AP trains, spine calcium changes follow each AP, but not in dendrites. Apart from the higher surface-to-volume ratio (SVR), we observed that neocortical dendritic spines have a markedly smaller endogenous buffer capacity with respect to their parental dendrites. Calcium influx time course and calcium extrusion rate were both in the same range for spines and dendrites when fitted with a dynamic multi-compartment model that included calcium binding kinetics and diffusion. In a subsequent analysis we used this model to investigate which parameters are critical determinants in spine calcium dynamics. The model confirmed the experimental findings: a higher SVR is not sufficient by itself to explain the faster rise time kinetics in spines, but only when paired with a lower buffer capacity in spines. Simulations at zero calcium-dye conditions show that calmodulin is more efficiently activated in spines, which indicates that spine morphology and buffering conditions in neocortical spines favor synaptic plasticity
Rings in the Solar System: a short review
Rings are ubiquitous around giant planets in our Solar System. They evolve
jointly with the nearby satellite system. They could form either during the
giant planet formation process or much later, as a result of large scale
dynamical instabilities either in the local satellite system, or at the
planetary scale. We review here the main characteristics of rings in our solar
system, and discuss their main evolution processes and possible origin. We also
discuss the recent discovery of rings around small bodies.Comment: Accepted for the Handbook of Exoplanet
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