Adaptive Randomized Distributed Space-Time Coding in Cooperative MIMO Relay Systems

An adaptive randomized distributed space-time coding (DSTC) scheme and algorithms are proposed for two-hop cooperative MIMO networks. Linear minimum mean square error (MMSE) receivers and an amplify-and-forward (AF) cooperation strategy are considered. In the proposed DSTC scheme, a randomized matrix obtained by a feedback channel is employed to transform the space-time coded matrix at the relay node. Linear MMSE expressions are devised to compute the parameters of the adaptive randomized matrix and the linear receive filter. A stochastic gradient algorithm is also developed to compute the parameters of the adaptive randomized matrix with reduced computational complexity. We also derive the upper bound of the error probability of a cooperative MIMO system employing the randomized space-time coding scheme first. The simulation results show that the proposed algorithms obtain significant performance gains as compared to existing DSTC schemes.Comment: 4 figure

Distributed Space-Time Coding Based on Adjustable Code Matrices for Cooperative MIMO Relaying Systems

An adaptive distributed space-time coding (DSTC) scheme is proposed for two-hop cooperative MIMO networks. Linear minimum mean square error (MMSE) receive filters and adjustable code matrices are considered subject to a power constraint with an amplify-and-forward (AF) cooperation strategy. In the proposed adaptive DSTC scheme, an adjustable code matrix obtained by a feedback channel is employed to transform the space-time coded matrix at the relay node. The effects of the limited feedback and the feedback errors are assessed. Linear MMSE expressions are devised to compute the parameters of the adjustable code matrix and the linear receive filters. Stochastic gradient (SG) and least-squares (LS) algorithms are also developed with reduced computational complexity. An upper bound on the pairwise error probability analysis is derived and indicates the advantage of employing the adjustable code matrices at the relay nodes. An alternative optimization algorithm for the adaptive DSTC scheme is also derived in order to eliminate the need for the feedback. The algorithm provides a fully distributed scheme for the adaptive DSTC at the relay node based on the minimization of the error probability. Simulation results show that the proposed algorithms obtain significant performance gains as compared to existing DSTC schemes.Comment: 6 figure

Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-in-Silico Approach Combining In Vitro Experiments and Machine Learning (vol 9, 393, 2018)

A Corrigendum on Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning by Zechendorf E, Vaßen P, Zhang J, Hallawa A, Martincuks A, Krenkel O, Müller-Newen G, Schuerholz T, Simon T-P, Marx G, Ascheid G, Schmeink A, Dartmann G, Thiemermann C and Martin L (2018). Front. Immunol. 9:393. doi: 10.3389/fimmu.2018.00393 In the original article, there was an error in the Author Contributions section. The wording used to declare the contribution of Elisabeth Zechendorf was not clear. The new Author Contributions section appears below. Conception and design: EZ, LM, GD, AS, and CT. In vitro experiments and data analyses: EZ, LM, TS, T-PS, AM, GM-N, OK, GM, and PV. Medical in silico experiments and data analyses: EZ, PV, JZ, GD, AS, LM, AH, and GA. EZ wrote the manuscript. Correction of the manuscript: EZ, PV, LM, CT, GM, GD, T-PS, and AS. All the authors reviewed and finally approved the manuscript. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated

A second generation cervico-vaginal lavage device shows similar performance as its preceding version with respect to DNA yield and HPV DNA results

Contains fulltext : 118480.pdf (publisher's version ) (Open Access)BACKGROUND: Attendance rates of cervical screening programs can be increased by offering HPV self-sampling to non-attendees. Acceptability, DNA yield, lavage volumes and choice of hrHPV test can influence effectiveness of the self-sampling procedures and could therefore play a role in recruiting non-attendees. To increase user-friendliness, a frequently used lavage sampler was modified. In this study, we compared this second generation lavage device with the first generation device within similar birth cohorts. METHODS: Within a large self-sampling cohort-study among non-responders of the Dutch cervical screening program, a subset of 2,644 women received a second generation self-sampling lavage device, while 11,977 women, matched for age and ZIP-code, received the first generation model. The second generation device was different in shape, color, lavage volume, and packaging, in comparison to its first generation model. The Cochran's test was used to compare both devices for hrHPV positivity rate and response rate. To correct for possible heterogeneity between age and ZIP codes in both groups the Breslow-Day test of homogeneity was used. A T-test was utilized to compare DNA yields of the obtained material in both groups. RESULTS: Median DNA yields were 90.4 mug/ml (95% CI 83.2-97.5) and 91.1 mug/ml (95% CI 77.8-104.4, p= 0.726) and hrHPV positivity rates were 8.2% and 6.9% (p= 0.419) per sample self-collected by the second - and the first generation of the device (p= 0.726), respectively. In addition, response rates were comparable for the two models (35.4% versus 34.4%, p= 0.654). CONCLUSIONS: Replacing the first generation self-sampling device by an ergonomically improved, second generation device resulted in equal DNA yields, comparable hrHPV positivity rates and similar response rates. Therefore, it can be concluded that the clinical performance of the first and second generation models are similar. Moreover, participation of non-attendees in cervical cancer screening is probably not predominantly determined by the type of self-collection device