Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is flanked in the protein determine the efficiency of processing and presentation. This became evident when a viral sequence of proven antigenicity was inserted at different positions into an unrelated carrier protein. Not different peptides, but different amounts of the antigenic insert itself were retrieved by isolation of naturally processed peptides from cells expressing the different chimeric proteins. Low yield of antigenic peptide from an unfavorable integration site could be overcome by flanking the insert with oligo-alanine to space it from disruptive neighboring sequences. Notably, the degree of protection against lethal virus disease related directly to the amount of naturally processed antigenic peptide

Excited by a quantum field: Does shape matter?

The instantaneous transition rate of an arbitrarily accelerated Unruh-DeWitt particle detector on four-dimensional Minkowski space is ill defined without regularisation. We show that Schlicht's regularisation as the zero-size limit of a Lorentz-function spatial profile yields a manifestly well-defined transition rate with physically reasonable asymptotic properties. In the special case of stationary trajectories, including uniform acceleration, we recover the results that have been previously obtained by a regularisation that relies on the stationarity. Finally, we discuss evidence for the conjecture that the zero-size limit of the transition rate is independent of the detector profile.Comment: 7 pages, uses jpconf. Talk given at NEB XII (Nafplio, Greece, 29 June - 2 July 2006

Selection Wages and Discrimination

Applicants for any given job are more or less suited to fill it, and the firm will select the best among them. Increasing the wage offer attracts more applicants and makes it possible to raise the hiring standard and improve the productivity of the staff. Wages that optimize on the trade-off between the wage level and the productivity of the workforce are known as selection wages. As men react more strongly to wage differentials than females, the trade-off is more pronounced for men and a profit-maximizing firm will offer a higher wage for men than for women in equilibrium

Accelerated detectors in Dirac vacuum: the effects of horizon fluctuations

We consider an Unruh-DeWitt detector interacting with a massless Dirac field. Assuming that the detector is moving along an hyperbolic trajectory, we modeled the effects of fluctuations in the event horizon using a Dirac equation with random coefficients. First, we develop the perturbation theory for the fermionic field in a random media. Further we evaluate corrections due to the randomness in the response function associated to different model detectors.Comment: 19 pages, 1 figur

Relativistic Quantum Information in Detectors-Field Interactions

We review Unruh-DeWitt detectors and other models of detector-field interaction in a relativistic quantum field theory setting as a tool for extracting detector-detector, field-field and detector-field correlation functions of interest in quantum information science, from entanglement dynamics to quantum teleportation. We in particular highlight the contrast between the results obtained from linear perturbation theory which can be justified provided switching effects are properly accounted for, and the nonperturbative effects from available analytic expressions which incorporate the backreaction effects of the quantum field on the detector behaviour.Comment: 21 pages, 3 figures. Prepared for the special focus issue on RQ

Mental health academics in rural and remote Australia

Context: The significant impact of mental ill health in rural and remote Australia has been well documented. Included among innovative approaches undertaken to address this issue has been the Mental Health Academic (MHA) project, established in 2007. Funded by the Australian Government (Department of Health), this project was established as a component of the University Departments of Rural Health (UDRH) program. All 11 UDRHs appointed an MHA. Although widely geographically dispersed, the MHAs have collaborated in various ways. The MHA project encompasses a range of activities addressing four key performance indicators. These activities, undertaken in rural and remote Australia, aimed to increase access to mental health services, promote awareness of mental health issues, support students undertaking mental health training and improve health professionals' capacity to recognise and address mental health issues. MHAs were strategically placed within the UDRHs across the country, ensuring an established academic base for the MHAs' work was available immediately. Close association with each local rural community was recognised as important. For most MHAs this was facilitated by having an established clinical role in their local community and actively engaging with the community in which they worked. In common with other rural health initiatives, some difficulties were experienced in the recruitment of suitable MHAs, especially in more remote locations. The genesis of this article was a national meeting of the MHAs in 2014, to identify and map the different types of activities MHAs had undertaken in their regions. These activities were analysed and categorised by the MHAs. These categories have been used as a guiding framework for this article. Issues: The challenge to increase community access to mental health services was addressed by (i) initiatives to address specific access barriers, (ii) supporting recruitment and retention of rural mental health staff, (iii) developing the skills of the existing workforce and (iv) developing innovative approaches to student placements. Strategies to promote awareness of mental health issues included workshops in rural and remote communities, specific suicide prevention initiatives and targeted initiatives to support the mental health needs of Indigenous Australians. The need for collaboration between the widely dispersed MHAs was identified as important to bridge the rural divide, to promote project cohesiveness and ensure new ideas in an emerging setting are readily shared and to provide professional support for one another as mental health academics are often isolated from academic colleagues with similar mental health interests. Lessons learned: The MHA project suggests that an integrated approach can be taken to address the common difficulties of community awareness raising of mental health issues, increasing access to mental health services, workforce recruitment and retention (access), and skill development of existing health professionals (access and awareness). To address the specific needs and circumstances of their community, MHAs have customised their activities. As in other rural initiatives, one size was found not to fit all. The triad of flexibility, diversity and connectedness (both to local community and other MHAs) describes the response identified as appropriate by the MHAs. The breadth of the MHA role to provide university sponsored educational activities outside traditional student teaching meant that the broader health workforce benefited from access to mental health training that would not otherwise have occurred. Provision of these additional educational opportunities addressed not only the need for increased education regarding mental health but also reduced the barriers commonly faced by rural health professionals in accessing quality professional development