Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is flanked in the protein determine the efficiency of processing and presentation. This became evident when a viral sequence of proven antigenicity was inserted at different positions into an unrelated carrier protein. Not different peptides, but different amounts of the antigenic insert itself were retrieved by isolation of naturally processed peptides from cells expressing the different chimeric proteins. Low yield of antigenic peptide from an unfavorable integration site could be overcome by flanking the insert with oligo-alanine to space it from disruptive neighboring sequences. Notably, the degree of protection against lethal virus disease related directly to the amount of naturally processed antigenic peptide

Excited by a quantum field: Does shape matter?

The instantaneous transition rate of an arbitrarily accelerated Unruh-DeWitt particle detector on four-dimensional Minkowski space is ill defined without regularisation. We show that Schlicht's regularisation as the zero-size limit of a Lorentz-function spatial profile yields a manifestly well-defined transition rate with physically reasonable asymptotic properties. In the special case of stationary trajectories, including uniform acceleration, we recover the results that have been previously obtained by a regularisation that relies on the stationarity. Finally, we discuss evidence for the conjecture that the zero-size limit of the transition rate is independent of the detector profile.Comment: 7 pages, uses jpconf. Talk given at NEB XII (Nafplio, Greece, 29 June - 2 July 2006

How often does the Unruh-DeWitt detector click? Regularisation by a spatial profile

We analyse within first-order perturbation theory the instantaneous transition rate of an accelerated Unruh-DeWitt particle detector whose coupling to a massless scalar field on four-dimensional Minkowski space is regularised by a spatial profile. For the Lorentzian profile introduced by Schlicht, the zero size limit is computed explicitly and expressed as a manifestly finite integral formula that no longer involves regulators or limits. The same transition rate is obtained for an arbitrary profile of compact support under a modified definition of spatial smearing. Consequences for the asymptotic behaviour of the transition rate are discussed. A number of stationary and nonstationary trajectories are analysed, recovering in particular the Planckian spectrum for uniform acceleration.Comment: 30 pages, 1 figure. v3: Added references and minor clarification

Selection Wages and Discrimination

Applicants for any given job are more or less suited to fill it, and the firm will select the best among them. Increasing the wage offer attracts more applicants and makes it possible to raise the hiring standard and improve the productivity of the staff. Wages that optimize on the trade-off between the wage level and the productivity of the workforce are known as selection wages. As men react more strongly to wage differentials than females, the trade-off is more pronounced for men and a profit-maximizing firm will offer a higher wage for men than for women in equilibrium

Accelerated detectors in Dirac vacuum: the effects of horizon fluctuations

We consider an Unruh-DeWitt detector interacting with a massless Dirac field. Assuming that the detector is moving along an hyperbolic trajectory, we modeled the effects of fluctuations in the event horizon using a Dirac equation with random coefficients. First, we develop the perturbation theory for the fermionic field in a random media. Further we evaluate corrections due to the randomness in the response function associated to different model detectors.Comment: 19 pages, 1 figur

Relativistic Quantum Information in Detectors-Field Interactions

We review Unruh-DeWitt detectors and other models of detector-field interaction in a relativistic quantum field theory setting as a tool for extracting detector-detector, field-field and detector-field correlation functions of interest in quantum information science, from entanglement dynamics to quantum teleportation. We in particular highlight the contrast between the results obtained from linear perturbation theory which can be justified provided switching effects are properly accounted for, and the nonperturbative effects from available analytic expressions which incorporate the backreaction effects of the quantum field on the detector behaviour.Comment: 21 pages, 3 figures. Prepared for the special focus issue on RQ