1,124 research outputs found
Quantitative comparison of performance analysis techniques for modular and generic network-on-chip
NoC-specific parameters feature a huge impact on performance and implementation costs of NoC. Hence, performance and cost evaluation of these parameter-dependent NoC is crucial in different design-stages but the requirements on performance analysis differ from stage to stage. In an early design-stage an analysis technique featuring reduced complexity and limited accuracy can be applied, whereas in subsequent design-stages more accurate techniques are required. <br><br> In this work several performance analysis techniques at different levels of abstraction are presented and quantitatively compared. These techniques include a static performance analysis using timing-models, a Colored Petri Net-based approach, VHDL- and SystemC-based simulators and an FPGA-based emulator. Conducting NoC-experiments with NoC-sizes from 9 to 36 functional units and various traffic patterns, characteristics of these experiments concerning accuracy, complexity and effort are derived. <br><br> The performance analysis techniques discussed here are quantitatively evaluated and finally assigned to the appropriate design-stages in an automated NoC-design-flow
Characterization and evolution of cell division and cell wall synthesis genes in the bacterial phyla Verrucomicrobia, Lentisphaerae, Chlamydiae and Planctomycetes and phylogenetic comparison with rRNA genes
In the past, studies on the relationships of the bacterial phyla Planctomycetes, Chlamydiae, Lentisphaerae, and
Verrucomicrobia using different phylogenetic markers have been controversial. Investigations based on 16S
rRNA sequence analyses suggested a relationship of the four phyla, showing the branching order Planctomycetes,
Chlamydiae, Verrucomicrobia/Lentisphaerae. Phylogenetic analyses of 23S rRNA genes in this study also
support a monophyletic grouping and their branching order—this grouping is significant for understanding
cell division, since the major bacterial cell division protein FtsZ is absent from members of two of the phyla
Chlamydiae and Planctomycetes. In Verrucomicrobia, knowledge about cell division is mainly restricted to the
recent report of ftsZ in the closely related genera Prosthecobacter and Verrucomicrobium. In this study, genes of
the conserved division and cell wall (dcw) cluster (ddl, ftsQ, ftsA, and ftsZ) were characterized in all verrucomicrobial
subdivisions (1 to 4) with cultivable representatives (1 to 4). Sequence analyses and transcriptional
analyses in Verrucomicrobia and genome data analyses in Lentisphaerae suggested that cell division is based on
FtsZ in all verrucomicrobial subdivisions and possibly also in the sister phylum Lentisphaerae. Comprehensive
sequence analyses of available genome data for representatives of Verrucomicrobia, Lentisphaerae, Chlamydiae,
and Planctomycetes strongly indicate that their last common ancestor possessed a conserved, ancestral type of
dcw gene cluster and an FtsZ-based cell division mechanism. This implies that Planctomycetes and Chlamydiae
may have shifted independently to a non-FtsZ-based cell division mechanism after their separate branchings
from their last common ancestor with Verrucomicrobia
Novel pyrazole inhibitors for discrimination between receptor-operated and store-operated Ca2+ entry
The 2015 Global Climate Legislation Study: a review of climate change legislation in 99 countries: summary for policy-makers
This report summarises the main insights from the 2015 Global Climate Legislation Study. It is the fifth edition in a series dating back to 2010 (Townshend et al., 2011). The 2015 edition covers 98 countries plus the EU, up from 66 in 2014, which together account for 93 per cent of global greenhouse gas emissions. The study is intended as a source of information for legislators, researchers and policy-makers. It is hoped that parliaments considering climate change legislation will benefit from the growing body of experience reflected in the study. Facilitating knowledge exchange among parliamentarians was one of the primary motivations behind the Climate Legislation Study when the series was conceived by the Grantham Research Institute, LSE and GLOBE International in 2010. Since then there have been many examples of parliamentarians learning from, and being inspired by, each other through forums such as GLOBE and the Inter-Parliamentary Union – the two co-sponsors of the 2015 study
Hasbara 2.0: Israel’s Public Diplomacy in the Digital Age
The Internet has been a counter-public space for Palestinian liberation politics for over a decade, and digital technologies have become an increasingly important tool for solidarity groups across the world. However, the Israeli state and Zionist supporters worldwide are harnessing the same technologies and platforms to mobilize technology primarily to increase pro-Israel sentiments. The aims of this article are to examine hasbara [Israeli public diplomacy] through an exploration of similar diplomacy programmes; to illustrate how social media have affected the basic algorithms of hasbara; and to probe the assertions of hasbara in the light of pro-Palestinian solidarity. Through a study of public diplomacy, this article critically analyzes hasbara as a site of contestation and a method that is hampered by contradictions. On the one hand, there has been a massive growth in hasbara in recent years—indicated by the increase in funding for it and by its professionalized and centralized character; and on the other hand, hasbara has attracted sharp critiques in Israel for its reputed failures. To understand this contradiction, hasbara must be placed within the context of Israel’s settler-colonialism, which sets the state apart from other ‘post-conflict’ states. This article reviews the methods utilized in hasbara, as well as their readjustment in the context of recent wars. Events in 2014 illustrate that hasbara actually destabilizes Israel’s diplomacy. Online journalism and the suppression of solidarity for Palestine together stimulate more criticism and, in turn, help to shift public opinion. Paradoxically, therefore, adjustments (‘hasbara 2.0’) have underlined the image of Israel as a colonial power engaged in violent occupation
Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly
Stressful life events exposure including bereavement, an event commonly experienced by elderly people, social support, marital status and satisfaction were examined in relation to antibody response to the annual trivalent influenza vaccination in an elderly community sample (N = 184). Antibody response was assessed at baseline, and at one and 12 months following vaccination. Taking into account baseline antibody titer, overall life events exposure and social support were not associated with response to any of the influenza strains. However, bereavement in the year prior to vaccination was negatively associated with the one-month response to the A/Panama and B/Shangdong strains. Being married and having higher marital satisfaction was also associated with higher peak responses to the A/Panama influenza strain at one month. The positive association between marital satisfaction and A/Panama response was particularly evident in the younger half of the married sample. These associations largely withstood adjustment for potential confounders. Thus, in the elderly, peak antibody response was associated with bereavement and marriage, and not the more general factors, life events and social support, related to antibody response in student samples. This suggests the importance of taking a life course approach to examining relationships between psychosocial factors and immunity, and that interventions to modify the impact of these factors should address those most salient for each age group
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