Efficient enantioselective synthesis of a beta-hydroxyepoxide building block for the construction of macrocyclic natural products

The synthesis of a protected beta-hydroxyepoxide macrolide building block in seven steps from commercially available (R)-3-hydroxybutyric acid methyl ester in 68% overall yield is described. (C) 1998 Elsevier Science Ltd. All rights reserved

Clinical EEG in cognitively impaired patients with Parkinson's Disease

Parkinson's Disease Dementia (PD-D) is one of the most important non-motor signs in advanced PD and is the most influencing factor predicting nursing home placement. PD-related Mild Cognitive Impairment (PD-MCI) is a potential prodromal stage of PD-D. The Grand Total EEG (GTE) score is a rating scale for clinical EEG (Electroencephalography) analyses which is useful in the evaluation of different types of dementia. The purpose of the present study was to investigate the relationship between a short version of the GTE score and severity of cognitive deficits in PD. Nineteen patients with PD underwent neuropsychological testing and resting state EEG. Significant correlations with deteriorating cognition (combined Mini Mental Status Examination/Clock Drawing Test) were found for the overall short GTE score (Spearman Rank correlation, ?=-.6; p>.05) and for the subscore "Frequency of Rhythmic Background Activity" (?=-.6; p>.05), indicating that these EEG measures increase with deteriorating cognition

Neue Wege zur Bestimmung der akuten Toxizitaet von Chemikalien Abschlussbericht

Available from TIB Hannover: DtF QN1(35,57) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman