Individual differences in children's scientific reasoning

Contains fulltext : 250516.pdf (Publisher’s version ) (Open Access)Radboud University, 17 juni 2022Promotor : Lazonder, A.W. Co-promotor : Molenaar, I.191 p

Celecoxib decreases prostaglandin E\u3csub\u3e2\u3c/sub\u3e concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer

Background Celecoxib inhibits PGE2 production in cancerous tissue. We previously reported that PGE2 levels in nipple aspirate fluid (NAF) and plasma were not decreased in women at increased breast cancer risk who received celecoxib 200 mg twice daily (bid). The endpoints of the current study were to determine if a short course of celecoxib 400 mg bid would decrease PGE2 levels in women 1) at increased breast cancer risk, and 2) with established breast cancer. Methods NAF and plasma samples were collected before, 2 weeks after taking celecoxib 400 mg bid, and two weeks after washout from 26 women who were at increased breast cancer risk. From 13 women with newly diagnosed breast cancer, NAF from the incident breast and plasma were collected before and on average 2 weeks after taking celecoxib. Additionally, in nine of the 13 women with breast cancer, NAF was collected from the contralateral breast. Results No consistent change in NAF or plasma PGE2 levels was noted in high risk premenopausal women. NAF PGE2 levels decreased after celecoxib administration in postmenopausal high risk women (p = 0.02), and in both the NAF (p = 0.02) and plasma (p = 0.03) of women with breast cancer. Conclusion Celecoxib 400 mg bid taken on average for 2 weeks significantly decreased NAF, but not plasma, PGE2 levels in postmenopausal high risk women, and decreased both NAF and plasma PGE2 levels in women with newly diagnosed breast cancer. PGE2 levels may predict celecoxib breast cancer prevention and treatment efficacy. Our observations are preliminary, and larger studies to confirm and extend these findings are warranted

Entropy Cost of "Erasure" in Physically Irreversible Processes

A restricted form of Landauer's Principle, independent of computational considerations, is shown to hold for thermal systems by reference to the joint entropy associated with conjugate observables. It is shown that the source of the compensating entropy for irreversible physical processes is due to the ontological uncertainty attending values of such mutually incompatible observables, rather than due to epistemic uncertainty as traditionally assumed in the information-theoretic approach. In particular, it is explicitly shown that erasure of logical (epistemic) information via reset operations is not equivalent to erasure of thermodynamic entropy, so that the traditional, information-theoretic form of Landauer's Principle is not supported by the physics. A further implication of the analysis is that there is no Maxwell's Demon in the real world.Comment: This version clarifies that the traditional, information-theoretic form of Landauer's Principle is not supported by the physics; however, a restricted form involving erasure of ontological uncertainty does hol

On the global nonlinear instability of the rotating-disk flow over a finite domain

Direct numerical simulations based on the incompressible nonlinear Navier–Stokes equations of the flow over the surface of a rotating disk have been conducted. An impulsive disturbance was introduced and its development as it travelled radially outwards and ultimately transitioned to turbulence has been analysed. Of particular interest was whether the nonlinear stability is related to the linear stability properties. Specifically three disk-edge conditions were considered; (i) a sponge region forcing the flow back to laminar flow, (ii) a disk edge, where the disk was assumed to be infinitely thin, and (iii) a physically-realistic disk edge of finite thickness. This work expands on the linear simulations presented by Appelquist et al. (J. Fluid. Mech., vol. 765, 2015, pp. 612-631), where, for case (i), this configuration was shown to be globally linearly unstable when the sponge region effectively models the influence of the turbulence on the flow field. In contrast, case (ii) was mentioned there to be linearly globally stable, and here, where nonlinearity is included, it is shown that both case (ii) and (iii) are nonlinearly globally unstable. The simulations show that the flow can be globally linearly stable if the linear wavepacket has a positive front velocity. However, in the same flow field, a nonlinear global instability can emerge, which is shown to depend on the outer turbulent region generating a linear inward-travelling mode that sustains a transition-front within the domain. The results show that the front position does not approach the critical Reynolds number for the local absolute instability, R = 507. Instead, the front approaches R = 583 and both the temporal frequency and spatial growth rate correspond to a global mode originating at this position.Swedish Research Counci

Do wildflower strips enhance pest control in organic cabbage?

Within this project we assess whether wildflower strips and companion plants increase the control of cabbage pests Plutella xylostella L. (Lepidoptera: Plutellidae), Mamestra brassicae L. (Lepidoptera: Noctuidae) and Pieris rapae L. (Lepidoptera: Pieridae) by (1) naturally occurring parasitoids and predators and (2) mass‐releasedn Trichogramma brassciae (Bezdenko) (Hymenoptera: Trichogrammatidae) parasitoids. Two organic cabbage fields were used for this study: adjacent to each field a wildflower strip was sown and companion plants (Centaurea cyanus L. (Asteraceae)) intermixed within the crop. Within each field ~15,000 M. brassicae eggs were placed out to determine the parasitism rates by mass‐released T. brassicae and to assess the levels of egg predation. Over 1,000 lepidopteran larvae were collected and screened for hymenopteran and tachinid parasitoid DNA using a multiplex PCR assay. Invertebrate generalist predators (n=1,063) were collected for DNA‐based gut content analysis. The wildflower strip had a significant positive effect on M. brassicae egg parasitism rates as rates increased 5‐fold in the vicinity to the strip. Moreover, companion plants enhanced invertebrate predation on M. brassicae eggs. Both, the release of T. brassicae and the use of companion plants, however, did not significantly increase egg parasitism rates. The infestation of plants by caterpillars increased with distance to the wildflower strip and there was a trend of decreasing larval parasitism rates with distance to the strip. Currently the invertebrate predators are being molecularly analysed to assess predation on unparasitized and parasitized lepidopteran pests