426 research outputs found
Self consistent kinetic simulations of SPT and HEMP thrusters including the near-field plume region
The Particle-in-Cell (PIC) method was used to study two different ion
thruster concepts - Stationary Plasma Thrusters (SPT) and High Efficiency
Multistage Plasma Thrusters (HEMP-T), in particular the plasma properties in
the discharge chamber due to the different magnetic field configurations.
Special attention was paid to the simulation of plasma particle fluxes on the
thrusters channel surfaces. In both cases, PIC proved itself as a powerful
tool, delivering important insight into the basic physics of the different
thruster concepts. The simulations demonstrated that the new HEMP thruster
concept allows for a high thermal efficiency due to both minimal energy
dissipation and high acceleration efficiency. In the HEMP thruster the plasma
contact to the wall is limited only to very small areas of the magnetic field
cusps, which results in much smaller ion energy flux to the thruster channel
surface as compared to SPT. The erosion yields for dielectric discharge channel
walls of SPT and HEMP thrusters were calculated with the binary collision code
SDTrimSP. For SPT, an erosion rate on the level of 1 mm of sputtered material
per hour was observed. For HEMP, thruster simulations have shown that there is
no erosion inside the dielectric discharge channel.Comment: 14 pages, 11 figures This work was presented at 21st International
Conference on Numerical Simulation of Plasmas (ICNSP'09
Herbal extracts modulate the amplitude and frequency of slow waves in circular smooth muscle of mouse small intestine
Background: Herbal preparations like STW 5 (Iberogast(R)) are widely used drugs in the treatment of dyspepsia and motility-related disorders of the gastrointestinal tract. STW 5 is a phytotherapeutic agent consisting of a fixed mixture of 9 individual plant extracts. The electrophysiological mechanisms of action of STW 5 remain obscure. Aim: The aim of the present study was to investigate whether herbal extracts influence electrophysiological parameters of the small intestine. For this purpose, the resting membrane potential (RMP) and the slow wave rhythmicity of smooth muscle cells of mouse small intestine were observed. Methods: Intracellular recordings of smooth muscle cells of the circular muscle layer of mouse small intestine were performed using standard microelectrode techniques. After dissection of the mucosa, the small intestine was placed in an organ bath and a microelectrode was applied on a circular smooth muscle cell. The RMP and the amplitude of slow waves were measured in millivolts. Results: The RMP of smooth muscle cells was - 59 +/- 1.3 mV. This RMP was significantly depolarized by STW 5 ( 9.6 +/- 1.6 mV); the depolarizing effects can be mainly attributed to the constituents of matricariae flos, angelicae radix and chelidonii herba. The basal frequency of small intestinal slow waves was 39.5 +/- 1.4 min(-1) and the amplitude was 23.1 +/- 0.9 mV. STW 5 significantly reduced the amplitude and frequency of the slow waves ( 11.7 +/- 0.8 mV; 33.5 +/- 3.4 min(-1)). This effect on slow waves represents the sum of the effects of the 9 phytoextracts. Whereas angelicae radix and matricariae flos completely blocked slow wave activity, Iberis amara increased the frequency and amplitude, chelidonii herba reduced the frequency and amplitude of the slow waves, mentae piperitae folium reduced the frequency and left amplitude unchanged and liquiritae radix, carvi fructus and melissae folium had no effects. Conclusion: Herbal extracts cause changes in smooth muscle RMP and slow wave rhythmicity, up to reversible abolition, by blockade of large conductance Ca2+ channels and other not yet identified mechanisms. In herbal preparations like STW 5 these effects add up to a total effect and this study indicates that herbal preparations which are widely used in dyspepsia and motility-related disorders have characteristic, reproducible, reversible effects on small intestinal electrophysiology. Copyright (C) 2005 S. Karger AG, Basel
NMR-based metabolomics: global analysis of metabolites to address problems in prostate cancer
Preliminary Investigation of Possible Biochar Use as Carbon Source in Polyacrylonitrile Electrospun Fiber Production
Electrospinning with consequent thermal treatment consists in a carbon fiber production method that spins a polymer solution to create fibers with diameters around a few hundred nanome-ters. The thermal treatments are used for the cyclization and then carbonization of the material at 1700âŠC for one hour. The unique structure of micro-and nano-carbon fibers makes them a promis-ing material for various applications ranging from future battery designs to filtration. This work investigated the possibility of using milled gasification biochar, derived from a 20 kW fixed-bed gasifier fueled with vine pruning pellets, as an addictive in the preparation of electrospinning solu-tions. This study outlined that solvent cleaning and the consequent wet-milling and 32 ”m sifting are fundamental passages for biochar preparation. Four different polyacrylonitrile-biochar shares were tested ranging from pure polymer to 50â50% solutions. The resulting fibers were analyzed via scanning electron microscopy, and energy-dispersive X-ray and infrared spectroscopy. Results from the morphological analysis showed that biochar grains dispersed themselves well among the fiber mat in all the proposed shares. All the tested solutions, once carbonized, exceeded 97%wt. of carbon content. At higher carbonization temperatures, the inorganic compounds naturally showing in biochar such as potassium and calcium disappeared, resulting in an almost carbon-pure fiber matrix with biochar grains in between
Ordinal Prototype-Based Classifiers
The identification of prototypical patterns is one of the major goals in the classification of microarray data. Prototype-based classifiers are of special interest in this context, since they allow a direct biological interpretation. In this work we present prototype-based classifiers that rely on ordinal-scaled data. Advantage of these ordinal-scaled signatures is their invariance to a wide range of data transformations. Standard prototype-based classifiers can be modified to this type of data by utilizing rank-distances and rank-aggregation procedures. In this study, we compare the proposed methods with standard classifiers. They are examined in experiments with and without feature selection on a panel of publicly available microarray datasets. We show that the proposed techniques result in the construction of different signatures that improve classification performance
Das Zeitstandfestigkeits- und Kriechverhalten des niedrigaktivierenden martensitischen Stahles F82H-mod. (AbschluĂbericht)
Experimentelle Ergebnisse zum Kriechverhalten des Strukturwerkstoffes 316-L (N)-DIN 1.4909 im niedrigen Spannungsbereich bei 550â° und 600â°C (Abschlussbericht)
Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population.
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