507 research outputs found
Self consistent kinetic simulations of SPT and HEMP thrusters including the near-field plume region
The Particle-in-Cell (PIC) method was used to study two different ion
thruster concepts - Stationary Plasma Thrusters (SPT) and High Efficiency
Multistage Plasma Thrusters (HEMP-T), in particular the plasma properties in
the discharge chamber due to the different magnetic field configurations.
Special attention was paid to the simulation of plasma particle fluxes on the
thrusters channel surfaces. In both cases, PIC proved itself as a powerful
tool, delivering important insight into the basic physics of the different
thruster concepts. The simulations demonstrated that the new HEMP thruster
concept allows for a high thermal efficiency due to both minimal energy
dissipation and high acceleration efficiency. In the HEMP thruster the plasma
contact to the wall is limited only to very small areas of the magnetic field
cusps, which results in much smaller ion energy flux to the thruster channel
surface as compared to SPT. The erosion yields for dielectric discharge channel
walls of SPT and HEMP thrusters were calculated with the binary collision code
SDTrimSP. For SPT, an erosion rate on the level of 1 mm of sputtered material
per hour was observed. For HEMP, thruster simulations have shown that there is
no erosion inside the dielectric discharge channel.Comment: 14 pages, 11 figures This work was presented at 21st International
Conference on Numerical Simulation of Plasmas (ICNSP'09
Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
Background: Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying.Aims: To assess the effects of endogenous GLP-1 on endocrine pancreatic secretion and antro-pyloro-duodenal motility by utilising the GLP-1 receptor antagonist exendin(9-39)amide (ex(9-39)NH2).Methods: Nine healthy volunteers underwent four experiments each. In two experiments with and without intravenous infusion of ex(9-39)NH2 300 pmol/kg/min, a fasting period was followed by intraduodenal glucose perfusion at 1 and 2.5 kcal/min, with the higher dose stimulating GLP-1 release. Antro-pyloro-duodenal motility was measured by perfusion manometry. To calculate the incretin effect (that is, the proportion of plasma insulin stimulated by intestinal hormones) the glycaemia observed during the luminal glucose experiments was mimicked using intravenous glucose in two further experiments.Results: Ex(9-39)NH2 significantly increased glycaemia during fasting and duodenal glucose. It diminished plasma insulin during duodenal glucose and significantly reduced the incretin effect by approximately 50%. Ex(9-39)NH2 raised plasma glucagon during fasting and abolished the decrease in glucagon at the high duodenal glucose load. Ex(9-39)NH2 markedly stimulated antroduodenal contractility. At low duodenal glucose it reduced the stimulation of tonic and phasic pyloric motility. At the high duodenal glucose load it abolished pyloric stimulation.Conclusions: Endogenous GLP-1 stimulates postprandial insulin release. The pancreatic \textgreeka cell is under the tonic inhibitory control of GLP-1 thereby suppressing postprandial glucagon. GLP-1 tonically inhibits antroduodenal motility and mediates the postprandial inhibition of antral and stimulation of pyloric motility. We therefore suggest GLP-1 as a true incretin hormone and enterogastrone in humans
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