Evolution of a beam dynamics model for the transport lines in a proton therapy facility

Despite the fact that the first-order beam dynamics models allow an approximated evaluation of the beam properties, their contribution is essential during the conceptual design of an accelerator or beamline. However, during the commissioning some of their limitations appear in the comparison against measurements. The extension of the linear model to higher order effects is, therefore, demanded. In this paper, the effects of particle-matter interaction have been included in the model of the transport lines in the proton therapy facility at the Paul Scherrer Institut (PSI) in Switzerland. To improve the performance of the facility, a more precise model was required and has been developed with the multi-particle open source beam dynamics code called OPAL (Object oriented Particle Accelerator Library). In OPAL, the Monte Carlo simulations of Coulomb scattering and energy loss are performed seamless with the particle tracking. Beside the linear optics, the influence of the passive elements (e.g. degrader, collimators, scattering foils and air gaps) on the beam emittance and energy spread can be analysed in the new model. This allows for a significantly improved precision in the prediction of beam transmission and beam properties. The accuracy of the OPAL model has been confirmed by numerous measurements.Comment: 17 pages, 19 figure

Acrylamide: Increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans

We have developed a liquid chromatography/mass spectrometry (LC-MS/MS) assay to determine acrylamide in various body fluids. The assay also allows the reliable quantitation of acrylamide in food. In a total of 11 healthy male and female subjects, we were able to show that acrylamide from food given to humans is in fact absorbed from the gut. The half-lives determined in two male subjects were 2.2 and 7 h. Acrylamide was found in human breast milk and penetrated the human placenta (n = 3). The variability of acrylamide concentrations found in this investigation is most likely caused by variable intersubject bioavailability and metabolism. This may be an important indication that the assessment of the risk from acrylamide for the individual may be very difficult without knowing the concentrations of acrylamide in the body. This should be considered in the design of any risk assessment study or post hoc analysis of earlier studies. At this time, we suggest that pregnant women and breast-feeding mothers avoid acrylamide-containing food. Copyright (C) 2002 S. Karger AG, Basel

Technical challenges for FLASH proton therapy

There is growing interest in the radiotherapy community in the application of FLASH radiotherapy, wherein the dose is delivered to the entire treatment volume in less than a second. Early pre-clinical evidence suggests that these extremely high dose rates provide significant sparing of healthy tissue compared to conventional radiotherapy without reducing the damage to cancerous cells. This interest has been reflected in the proton therapy community, with early tests indicating that the FLASH effect is also present with high dose rate proton irradiation. In order to deliver clinically relevant doses at FLASH dose rates significant technical hurdles must be overcome in the accelerator technology before FLASH proton therapy can be realised. Of these challenges, increasing the average current from the present clinical range of 1–10 nA to in excess of 100 nA is at least feasible with existing technology, while the necessity for rapid energy adjustment on the order of a few milliseconds is much more challenging, particularly for synchrotron-based systems. However, the greatest challenge is to implement full pencil beam scanning, where scanning speeds 2 orders of magnitude faster than the existing state-of-the-art will be necessary, along with similar improvements in the speed and accuracy of associated dosimetry. Hybrid systems utilising 3D-printed patient specific range modulators present the most likely route to clinical delivery. However, to correctly adapt and develop existing technology to meet the challenges of FLASH, more pre-clinical studies are needed to properly establish the beam parameters that are necessary to produce the FLASH effect

Enhanced dielectronic recombination of lithium-like Ti19+ ions in external ExB fields

Dielectronic recombination(DR) of lithium-like Ti19+(1s2 2s) ions via 2s->2p core excitations has been measured at the Heidelberg heavy ion storage ring TSR. We find that not only external electric fields (0 <= Ey <= 280 V/cm) but also crossed magnetic fields (30 mT <= Bz <= 80 mT) influence the DR via high-n (2p_j nl)-Rydberg resonances. This result confirms our previous finding for isoelectronic Cl14+ ions [Bartsch T et al, PRL 82, 3779 (1999)] that experimentally established the sensitivity of DR to ExB fields. In the present investigation the larger 2p_{1/2}-2p_{3/2} fine structure splitting of Ti19+ allowed us to study separately the influence of external fields via the two series of Rydberg DR resonances attached to the 2s -> 2p_{1/2} and 2s -> 2p_{3/2} excitations of the Li-like core, extracting initial slopes and saturation fields of the enhancement. We find that for Ey > 80 V/cm the field induced enhancement is about 1.8 times stronger for the 2p_{3/2} series than for the 2p_{1/2} series.Comment: 10 pages, 3 figures, to be published in Journal of Physics B, see also http://www.strz.uni-giessen.de/~k

Large interfacial spin-orbit torques in layered antiferromagnetic insulator NiPS3/ferromagnet bilayers

Finding efficient ways of manipulating magnetic bits is one of the core goals in spintronic research. Electrically-generated spin-orbit torques (SOTs) are good candidates for this and the search for materials capable of generating highly-efficient SOTs has gained a lot of traction in the recent years. While antiferromagnet/ferromagnet bilayer structures have been employed extensively for passive applications, e.g. by using exchange bias fields, their active properties are not yet widely employed. Here we show the presence of large interfacial SOTs in bilayer of a ferromagnet and the two-dimensional layered antiferromagnetic insulator NiPS$_3$. We observe a large in-plane damping-like interfacial torque, showing a torque conductivity of $\sigma_\mathrm{DL} \approx 1 \times 10^{5} \mathrm{(\frac{\hbar}{2e}) /(\Omega m)}$ even at room temperature, comparable to the best devices reported in the literature for standard heavy-metal-based and topological insulators-based devices. Additionally, our devices also show an out-of-plane field-like torque arising from the NiPS$_3$/ferromagnet interface, further indicating the presence of an interfacial spin-orbit coupling in our structures. Temperature-dependent measurements reveal an increase of the SOTs with a decreasing temperature below the N\'eel temperature of NiPS$_3$ ($T_N \approx 170 \mathrm{K}$), pointing to a possible effect of the magnetic ordering on our measured SOTs. Our findings show the potential of antiferromagnetic insulators and two-dimensional materials for future spintronic applications.Comment: 19 pages, 3 figures, 1 table. Changed units of the torque normalized by the electric field from $\mathrm{\mu m \, T/V}$ to $\mathrm{nm \, T/V}

Absolute rate coefficients for photorecombination of berylliumlike and boronlike silicon ions

We report measured rate coefficients for electron-ion recombination for Si10+ forming Si9+ and for Si9+ forming Si8+, respectively. The measurements were performed using the electron-ion merged-beams technique at a heavy-ion storage ring. Electron-ion collision energies ranged from 0 to 50 eV for Si9+ and from 0 to 2000 eV for Si10+, thus, extending previous measurements for Si10+ [Orban et al. 2010, Astrophys. J. 721, 1603] to much higher energies. Experimentally derived rate coefficients for the recombination of Si9+ and Si10+ ions in a plasma are presented along with simple parameterizations. These rate coefficients are useful for the modeling of the charge balance of silicon in photoionized plasmas (Si9+ and Si10+) and in collisionally ionized plasmas (Si10+ only). In the corresponding temperature ranges, the experimentally derived rate coefficients agree with the latest corresponding theoretical results within the experimental uncertainties.Comment: 17 pages, 7 figures, 3 tables, 66 references, submitted to the J. Phys. B special issue on atomic and molecular data for astrophysicist

Interference effects in the photorecombination of argonlike Sc3+ ions: Storage-ring experiment and theory

Absolute total electron-ion recombination rate coefficients of argonlike Sc3+(3s2 3p6) ions have been measured for relative energies between electrons and ions ranging from 0 to 45 eV. This energy range comprises all dielectronic recombination resonances attached to 3p -> 3d and 3p -> 4s excitations. A broad resonance with an experimental width of 0.89 +- 0.07 eV due to the 3p5 3d2 2F intermediate state is found at 12.31 +- 0.03 eV with a small experimental evidence for an asymmetric line shape. From R-Matrix and perturbative calculations we infer that the asymmetric line shape may not only be due to quantum mechanical interference between direct and resonant recombination channels as predicted by Gorczyca et al. [Phys. Rev. A 56, 4742 (1997)], but may partly also be due to the interaction with an adjacent overlapping DR resonance of the same symmetry. The overall agreement between theory and experiment is poor. Differences between our experimental and our theoretical resonance positions are as large as 1.4 eV. This illustrates the difficulty to accurately describe the structure of an atomic system with an open 3d-shell with state-of-the-art theoretical methods. Furthermore, we find that a relativistic theoretical treatment of the system under study is mandatory since the existence of experimentally observed strong 3p5 3d2 2D and 3p5 3d 4s 2D resonances can only be explained when calculations beyond LS-coupling are carried out.Comment: 11 pages, 7 figures, 3 tables, Phys. Rev. A (in print), see also: http://www.strz.uni-giessen.de/~k