Adiabatic connection at negative coupling strengths

The adiabatic connection of density functional theory (DFT) for electronic systems is generalized here to negative values of the coupling strength $\alpha$ (with {\em attractive} electrons). In the extreme limit $\alpha\to-\infty$ a simple physical solution is presented and its implications for DFT (as well as its limitations) are discussed. For two-electron systems (a case in which the present solution can be calculated exactly), we find that an interpolation between the limit $\alpha\to-\infty$ and the opposite limit of infinitely strong repulsion ($\alpha\to+\infty$) yields a rather accurate estimate of the second-order correlation energy E\cor\glt[\rho] for several different densities $\rho$, without using virtual orbitals. The same procedure is also applied to the Be isoelectronic series, analyzing the effects of near-degeneracy.Comment: 9 pages, submitted to PR

Detection of Overhead Contact Lines with a 2D-Digital-Beamforming Radar System for Automatic Guidance of Trolley Trucks

The benefit of trolley truck systems is the substitution of the diesel fuel by the cheaper and more ecological electrical energy. Trolley trucks are powered by electricity fromtwo overhead contact lines, where one is the supply and the other the return conductor. Such trolley trucks are used for haulage at open pit mining sites but could also be used for freight traffic at roadways in the future. Automatic guidance prevents the trolley-powered trucks fromleaving the track and thus allows higher operating speeds, higher loading capacity, and greater efficiency. Radar is the ideal sensing technique for automatic guidance in such environments.The presented radar systemwith two-dimensional digital beamforming capability offers a compact measurement solution as it can be installed on top of the truck. Besides the distance measurement, this radar system allows to detect the location and inclination of the overhead contact lines by digital beamforming in two dimensions. Besides automatic guidance, the knowledge of the inclination of the overhead contact lines could allow automatic speed adaption, which would help to achieve maximum speed especially in hilly terrain

Factors of subjective heat stress of urban citizens in contexts of everyday life

Heat waves and the consequent heat stress of urban populations have a growing relevance in urban risk management and strategies of urban adaptation to climate change. In this context, social science studies on subjective heat stress of urban citizens are a new emerging field. To contribute to the understanding of subjective heat stress and its major determinants in a daily life perspective, we conducted a questionnaire survey with 323 respondents in Karlsruhe, Germany, after a heat wave in July and August 2013. Statistical data analysis showed that heat stress is an issue permeating everyday activities. It was found that the subjective heat stress at home is lower than at work and in general. Subjective heat stress in general, at home, and at work was determined by the health impairments experienced during the heat and the feeling of being helplessly exposed to the heat. For heat stress at home, additionally characteristics of the residential building and the built environment played a role. Although the rate of implemented coping measures was rather high, coping measures showed no uniform effect for the subjective heat stress. The results furthermore show that coping with heat is performed within the scopes of action in daily life. We conclude that in terms of urban adaptation strategies, further research is needed to understand how various processes of daily social (work) life enable or limit individual coping and adaptation capacities and that communication strategies are important for building capacities to better cope with future heat waves

Incidence of Ovine Progressive Pneumonia in the North Dakota State University Sheep Flocks, Determined by Agar-gel Immunodiffusion

In 1968, the causative agent of OPP, ovine progressive pneumonia virus (PPV) or Lunger's Disease was first isolated in the United States. A serological test, agar-gel imuno-diffusion (AGID) was applied for the detection of precipitating antibodies aginst PPV in sheep sera (colostrum-whey) against PPV is indicative of infection. But, antibodies are evidently play no part in fighting infection. By the time taht antibodies are produced, the virus is residing intracellularly and is unattainable to antibodies. The article gives a description of the symptoms and effects of the disease. The objective of this study was to characterize the extent of OPP in a naturally infected sheep flock by AGID, to determine whether differences in age or breed of the sheep influences the susceptibility to OPP and to attempt to establish an OPP-free from an infected source flock. The incidence of ovine progressive pneumonia by breed and age in a naturally infected flock was determined. An ovine progressive pneumonia free flock was established five years prior

Biomass-Derived Heteroatom-Doped Carbon Aerogels from a Salt Melt Sol–Gel Synthesis and their Performance in Li–S Batteries

An ionothermal sol–gel strategy to synthesize hierarchically porous carbon aerogels doped with different heteroatoms is presented by using biomass precursors in a scalable process. Morphologically similar but chemically different materials are used to study the influence of heteroatoms in Li–S batteries. The materials show capacities as high as 1290 mAh g−1 in the first cycle using 50 wt % S loading. Heteroatom doping reduces the capacity fading and the polarization throughout cycling. Zeta potential measurements reveal positive surface charges for heteroatom-doped carbons and indicate attractive interactions with polysulfides causing reduced fading. A polysulfide-selective sorption study reveals strongly different adsorption behavior depending on the carbon’s chemical composition. Interestingly, the polysulfide fraction is also crucial. The results indicate that improved adsorption of long-chain polysulfides to doped carbons is related to improved capacity retention

Percutaneous reduction and fixation of intraarticular calcaneal fractures

Objective: Percutaneous reduction by distraction and subsequent percutaneous screw fixation to restore calcaneal and posterior talocalcaneal facet anatomy. The aim of this technique is to improve functional outcome and to diminish the rate of secondary posttraumatic arthrosis compared to conservative treatment and, secondly, to reduce infectious complications compared to open reduction and internal fixation (ORIF). Indications: Sanders type II-IV displaced intraarticular calcaneal fractures. Contraindications: Isolated centrally depressed fragment. Contraindications: Patients who are expected to be noncompliant. Surgical Technique: Four distractors (Synthes™) are positioned, two on each side of the foot, between the tuberosity of the calcaneus and talus and between the tuberosity and cuboid. A distracting force is given over all four distractors. A blunt drifter is then introduced from the plantar side to unlock and push up any remaining depressed parts of the subtalar joint surface of the calcaneus. The reduction is fixated with two or three screws inserted percutaneously. Postoperative Management: Directly postoperatively, full active range of motion exercises of the ankle joint can start, with the foot elevated in the 1st postoperative week. Stitches are removed after 14 days. Implant removal is necessary in 50-60% of patients. Results: Between 1999 and 2004, 59 patients with 71 fractures were treated by percutaneous skeletal triangular distraction and percutaneous fixation. A total of 50 patients with 61 fractures and a minimum follow-up of 1 year were available for follow-up. According to the American Orthopaedic Foot and Ankle Society Hindfoot Score, 72% had a good to excellent result. A secondary subtalar arthrodesis was performed in five patients and planned in four (total 15%). Böhler's angle increased by about 20° postoperatively. Sagittal motion was 90% andsubtalar motion 70% compared to the healthy foot

Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale

Lasers have been proven to be precise tools for bone ablation. Applying no mechanical stress to the patient, they are potentially very suitable for microsurgery on fragile structures such as the inner ear. However, it remains challenging to control the laser-bone ablation without injuring embedded soft tissue. In this work, we demonstrate a closed-loop control of a short-pulsed CO2 laser to perform laser cochleostomy under the monitoring of an optical coherence tomography (OCT) system. A foresighted detection of the bone-endosteum-perilymph boundary several hundred micrometers before its exposure has been realized. Position and duration of the laser pulses are planned based on the residual bone thickness distribution. OCT itself is also used as a highly accurate tracking system for motion compensation between the target area and the optics. During ex vivo experimental evaluation on fresh porcine cochleae, the ablation process terminated automatically when the thickness of the residual tissue layer uniformly reached a predefined value. The shape of the resulting channel bottom converged to the natural curvature of the endosteal layer without injuring the critical structure. Preliminary measurements in OCT scans indicated that the mean absolute accuracy of the shape approximation was only around 20 μm

Professional Skills and Competence for Safe and Effective Procedural Sedation in Children: Recommendations Based on a Systematic Review of the Literature

Objectives. To investigate which skills and competence are imperative to assure optimal effectiveness and safety of procedural sedation (PS) in children and to analyze the underlying levels of evidence. Study Design and methods. Systematic review of literature published between 1993 and March 2009. Selected papers were classified according to their methodological quality and summarized in evidence-based conclusions. Next, conclusions were used to formulate recommendations. Results. Although the safety profiles vary among PS drugs, the possibility of potentially serious adverse events and the predictability of depth and duration of sedation define the imperative skills and competence necessary for a timely recognition and appropriate management. The level of effectiveness is mainly determined by the ability to apply titratable PS, including deep sedation using short-acting anesthetics for invasive procedures and nitrous oxide for minor painful procedures, and the implementation of non-pharmacological techniques. Conclusions. PS related safety and effectiveness are determined by the circumstances and professional skills rather than by specific pharmacologic characteristics. Evidence based recommendations regarding necessary skills and competence should be used to set up training programs and to define which professionals can and cannot be credentialed for PS in children

New Improved cGMP Analogues to Target Rod Photoreceptor Degeneration

: Retinitis pigmentosa (RP) is a form of retinal degeneration affecting a young population with an unmet medical need. Photoreceptor degeneration has been associated with increased guanosine 3',5'-cyclic monophosphate (cGMP), which reaches toxic levels for photoreceptors. Therefore, inhibitory cGMP analogues attract interest for RP treatments. Here we present the synthesis of dithio-CN03, a phosphorodithioate analogue of cGMP, prepared using the H-phosphonothioate route. Two crystal modifications were identified as a trihydrate and a tetrahydrofuran monosolvates. Dithio-CN03 featured a lower aqueous solubility than its RP-phosphorothioate counterpart CN03, a drug candidate, and this characteristic might be favorable for sustained-release formulations aimed at retinal delivery. Dithio-CN03 was tested in vitro for its neuroprotective effects in photoreceptor models of RP. The comparison of dithio-CN03 to CN03 and its diastereomer SP-CN03, and to their phosphate derivative oxo-CN03 identifies dithio-CN03 as the compound with the highest efficacy in neuroprotection and thus as a promising new candidate for the treatment of RP