Prevalência Da Artrite Idiopática Juvenil Em Escolares Prevalência Da Artrite Idiopática Juvenil Em Escolares Da Cidade De São Paulo

Introduction: Juvenile Idiopathic Arthritis (Jia) Is A Chronic Inflammatory Disease That Affects The Joints And Other Organs Of Children And Adolescents. Its Prevalence Varies Greatly From One Study To Another, According To The Population And Methodology Employed, Including Data Records And Active Patient Search. Some Tools May Be Helpful In Screening Suspected Cases. Objective: To Determine The Prevalence Of Jia In School Children And Adolescents In The City Of São Paulo, Brazil, Through The Use Of A Specific Questionnaire Followed By A Physical Examination. Casuistry And Methods: Sampling Planning Was Carried Out Based On Information From The School Census Of 2013, Establishing A Sample Number Of 10,670 Students, To Guarantee A Sampling Error Of 0.1% And A 95% Confidence Level. We Map All Private Schools In The City Of São Paulo, With Randomization Of Those With More Than 1,000 Students. We Sent The Questionnaire "Early Diagnosis Of Chronic Arthritis - 12 Items (Dpa-12)" To The Parents Of All Students In ThIntrodução: A Artrite Idiopática Juvenil (Aij) É Uma Doença Inflamatória Crônica Que Acomete As Articulações E Outros Órgãos De Crianças E Adolescentes. Sua Prevalência Varia Muito De Um Estudo Para Outro, De Acordo Com A População E Metodologia Empregada, Incluindo Registros De Dados E Busca Ativa De Pacientes. Algumas Ferramentas Podem Ser Úteis Na Triagem De Casos Suspeitos. Objetivo: Determinar A Prevalência Da Aij Em Crianças E Adolescentes Escolares Da Cidade De São Paulo, Brasil, Através Do Uso De Um Questionário Específico Seguido De Exame Físico Reumatológico. Casuística E Métodos: Foi Realizado Planejamento Amostral Com Base Em Informações Do Censo Escolar De 2013, Estabelecendo Número Amostral De 10.670 Alunos, Para Garantir Erro Amostral De 0,1% E Nível De Confiança De 95%. Realizamos Mapeamento De Todas As Escolas Particulares Da Cidade De São Paulo, Com Randomização Daquelas Com Mais De 1.000 Alunos. Enviamos O Questionário De "Diagnóstico Precoce Da Artrite Crônica " 12 Itens (Dpa- 12)", Para ODados abertos - Sucupira - Teses e dissertações (2018

Low-Level Laser Therapy Decreases Renal Interstitial Fibrosis

Objective: the purpose of this study was to investigate the effect of low-level laser therapy (LLLT) on chronic kidney disease (CKD) in a model of unilateral ureteral obstruction (UUO). Background data: Regardless of the etiology, CKD involves progressive widespread tissue fibrosis, tubular atrophy, and loss of kidney function. This process also occurs in kidney allograft. At present, effective therapies for this condition are lacking. We investigated the effects of LLLT on the interstitial fibrosis that occurs after experimental UUO in rats. Methods: The occluded kidney of half of the 32 Wistar rats that underwent UUO received a single intraoperative dose of LLLT (AlGaAs laser, 780 nm, 22.5 J/cm(2), 30mW, 0.75W/cm(2), 30 sec on each of nine points). After 14 days, renal fibrosis was assessed by Sirius red staining under polarized light. Immunohistochemical analyses quantitated the renal tissue cells that expressed fibroblast (FSP-1) and myofibroblast (alpha-SMA) markers. Reverse transcriptase polymerase chain reaction (RT-PCR) was performed to determine the mRNA expression of interleukin (IL)-6, monocyte chemotactic protein-1 (MCP-1), transforming growth factor (TGF)-beta 1 and Smad3. Results: The UUO and LLLT animals had less fibrosis than the UUO animals, as well having decreased expression inflammatory and pro-fibrotic markers. Conclusions: For the first time, we showed that LLLT had a protective effect regarding renal interstitial fibrosis. It is conceivable that by attenuating inflammation, LLLT can prevent tubular activation and transdifferentiation, which are the two processes that mainly drive the renal fibrosis of the UUO model.Coordenacao de aperfeicoamento de Pessoal de Nivel Superior (CAPES) [4019/2009]Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) [APQ-01501-09]Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG

Proceedings Of The 23Rd Paediatric Rheumatology European Society Congress: Part Two

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