CSF sTREM2: Marking the tipping point between preclinical AD and dementia?

Biomarkers for Alzheimer's disease (AD) have improved our understanding of the temporal sequence of biological events that lead to AD dementia (Jack et al, 2013). AD is characterized neuropathologically by amyloid plaques comprised of the amyloid‐β peptide and neurofibrillary tangles comprised of tau. Brain amyloid deposition, as evidenced by a decline in amyloid‐β peptide 42 (Aβ42) in the cerebrospinal fluid (CSF) or by binding of amyloid PET ligands, is thought to be a key initiating event in AD and begins many years prior to the onset of dementia. A rise in CSF tau and phosphorylated tau in the setting of Aβ deposition appears to reflect neurodegeneration and also begins years prior to the onset of dementia but after Aβ deposition has begun to accumulate. Individuals with “preclinical AD,” that is, normal cognition but abnormal AD biomarkers, have a much higher risk for developing AD dementia but may remain cognitively normal for years (Vos et al, 2013). While deposition of amyloid and formation of tau tangles are necessary for AD to occur, it is likely that additional events involving inflammation or other processes contribute to crossing the tipping point from preclinical AD to AD dementia. Current efforts are aimed at defining the biomarker(s) that best predict the transition from cognitive normality to abnormality. A biomarker that is closely associated with the onset of cognitive decline could help us to understand the biological events that connect amyloid deposition and tangle formation to cognitive decline and could have significant practical value in AD diagnosis and clinical trial design

Geoscience of Climate and Energy 12. Water Quality Issues in the Oil Sands Region of the Lower Athabasca River, Alberta

I summarize the controversies about industrial pollutants in freshwaters near the oil sands industrial area of Alberta, the inadequacies in environmental monitoring that have led to widespread misconceptions, and recent attempts to correct the problems.  Adequate data are available to show that mercury, other trace metals, and polycyclic aromatic compounds are being added by industry to the Athabasca river system and its watershed, although the relative contributions of industrial development and natural sources remain in question.  Recent improvements in water monitoring by Environment Canada show promise of resolving the controversies, although independent governance for Canada’s and Alberta’s water monitoring programs in the lower Athabasca River will be necessary to rebuild public confidence in the data and their interpretation by government and industry.  I document one success story in the Athabasca River: the elimination of dioxins from pulp mills in the mid-1990s has caused a consumption advisory for fish in the river to be repealed.SOMMAIREJe présente ci-dessous un résumé des controverses concernant les polluants industriels dans les eaux douces à proximité de la zone industrielle des sables bitumineux de l'Alberta, des lacunes dans la surveillance des milieux de vie à l’origine d’idées fausses répandues, et de récentes tentatives visant à corriger les problèmes.  Des données adéquates démontrent que l’industrie ajoute du mercure et d'autres métaux traces ainsi que des composés aromatiques polycycliques dans le système fluvial de la rivière Athabasca et dans son bassin versant, bien que les contributions relatives provenant de ces activités industrielles et de sources naturelles demeurent toujours en litige.  De récentes améliorations apportées au contrôle des eaux par Environnement Canada permettent d’espérer une résolution des controverses, mais l’application d’une gouvernance indépendante des programmes de contrôle de l'eau de l'Alberta du Canada dans la partie inférieure du fleuve Athabasca sera nécessaire pour rétablir la confiance de la population à l’égard des données présentées et de leur interprétation par le gouvernement et l'industrie.  Je décrie l’histoire d’une intervention réussie dans la rivière Athabasca, soit l'élimination de dioxines provenant des usines de pâte du milieu des années 1990 et qui a abouti à l’abrogation d’un avis de limitation de la consommation de poisson dans la rivière.DOI: http://dx.doi.org/10.12789/geocanj.2013.40.01

Wide-field weak lensing by RXJ1347-1145

We present an analysis of weak lensing observations for RXJ1347-1145 over a 43' X 43' field taken in B and R filters on the Blanco 4m telescope at CTIO. RXJ1347-1145 is a massive cluster at redshift z=0.45. Using a population of galaxies with 20<R<26, we detect a weak lensing signal at the p<0.0005 level, finding best-fit parameters of \sigma_v=1400^{+130}_{-140} km s^{-1} for a singular isothermal sphere model and r_{200} = 3.5^{+0.8}_{-0.2} Mpc with c = 15^{+64}_{-10} for a NFW model in an \Omega_m = 0.3, \Omega_\Lambda = 0.7 cosmology. In addition, a mass to light ratio M/L_R =90 \pm 20 M_\odot / L_{R\odot} was determined. These values are consistent with the previous weak lensing study of RXJ1347--1145 by Fischer and Tyson, 1997, giving strong evidence that systemic bias was not introduced by the relatively small field of view in that study. Our best-fit parameter values are also consistent with recent X-ray studies by Allen et al, 2002 and Ettori et al, 2001, but are not consistent with recent optical velocity dispersion measurements by Cohen and Kneib, 2002.Comment: accepted to ApJ, tentative publication 10 May 2005, v624

Impulse Purchases, Gun Ownership and Homicides:Evidence from a Firearm Demand Shock

Do firearm purchase delay laws reduce aggregate homicide levels? Using quasi-experimental evidence from a 6-month countrywide gun demand shock starting in late 2012, we show that U.S. states with legislation preventing immediate handgun purchases experienced smaller increases in handgun sales. Our findings are hard to reconcile with entirely rational consumers, but suggest that gun buyers behave time-inconsistently. In a second step, we demonstrate that states with purchase delays also witnessed 3% lower homicide rates during the same period compared to states allowing instant handgun access. We report suggestive evidence that lower handgun sales primarily reduced impulsive assaults and domestic violence

muCap: Connecting FaceReader™ to z-Tree

μCap (muCap) is a software package (citeware) for economic experiments enabling experimenters to analyze emotional states of subjects using z-Tree and FaceReader™. μCap is able to create videos of subjects on client computers based on stimuli shown on screen and restrict recording material to relevant time frames. Another feature of μCap is the creation of time stamps in csv format at prespecified screens (or at prespecified points in time) during the experiment, measured on the client computer. The software makes it possible to import these markers into FaceReader™ easily. Until recently, connecting z-Tree and FaceReader™ was only possible using workarounds or by undertaking many successive actions manually. μCap is the first program that significantly simplifies this process with the additional benefit of extremely high precision. This paper describes the usage, underlying principles as well as advantages and limitations of μCap. Furthermore, we give a brief outlook of how μCap can be beneficial in other contexts

Impulse Purchases, Gun Ownership and Homicides:Evidence from a Firearm Demand Shock

Do firearm purchase delay laws reduce aggregate homicide levels? Using variation from a 6-month countrywide gun demand shock in 2012/2013, we show that U.S. states with legislation preventing immediate handgun purchases experienced smaller increases in handgun sales. Our findings indicate that this is likely driven by comparatively lower purchases among impulsive consumers. We then demonstrate that states with purchase delays also witnessed comparatively 2% lower homicide rates during the same period. Further evidence shows that lower handgun sales coincided primarily with fewer impulsive assaults and points towards reduced acts of domestic violence

Coding over Core Models

Early in their careers, both Peter Koepke and Philip Welch made major contributions to two important areas of set theory, core model theory and coding, respectively. In this article we aim to survey some of the work that has been done which combines these two themes, extending Jensen's original Coding Theorem from $L$ to core models witnessing large cardinal properties