De visserskaai te Oostende (prov. West-Vlaanderen): archeologie van een in de 17de eeuw zwaar geteisterde stad

The Institute for the Archaeological Heritage of the Flemish Community (IAP) has, in close collaboration with the town of Ostend, carried out archaeological excavations during the construction works of the car park below the Visserskaai at Ostend from September 1998 till February 1999. This archaeological work mainly produced information on the eastern ramparts of Ostend and their evolution from the 16th century onwards together with information on the material culture of the inhabitants of Ostend during this same period. The town of Ostend had no defences until late in the 16th century as initial construction work for the defences only started in 1572 when the town came into northern hands. In the beginning of the 17th century Ostend managed to withstand successfully, with its newly built ramparts, for three years an overwhelming Spanish army siege. This was only possible thanks to the fact that the Spaniards never managed to seal of Ostend completely from the sea. As a result, victuals and soldiers arrived continuously at Ostend during the siege. It was only after the arrival of Spinola in the besieging camp, at the end of 1603, that Ostend was gradually forced to surrender. At the bottom of the excavated car park trench, some 4 m below the actual street level, wooden structures of the earthen ramparts were preserved (figs. 4-5). The presence of these con- firms historical data about the use of wood to strengthen the earthen ramparts. The excavations however documented mainly features from 2 bastions, the Peckels bastion and the Spanish bastion (fig. 2-3). Human burials and a gunpowder-magazine (figs. 7, 8, 10, 12) were uncovered in the Peckels bastion and human burials and an open-air rainwater reservoir were detected in the Spanish bastion. The human burials are studied elsewhere in this volume together with other post-medieval burials from Ostend recently discovered outside regular cemeteries. Archaeological material found in connection with the gunpowder-magazine in the Peckelf bastion dates from the 2nd half of the 16th /1st half of the 17th century (figs. 6,9,13-15) and suggests that the construction of this gunpowder-magazine? has to be situated somewhere in the middle of the 17th century, in other words in the period when the town defences of Ostend were adapted to new standards after the above- mentioned siege. A typical object related to the siege is a funnel-shaped gunpowder-flask in a copper-alloy (fig. 6). The inner wall of the gunpowder-magazine was erected on a framework of horizontal wooden beams, which were themselves resting on vertically placed and sharpened beams, mainly in oak (fig. 8). A dendrochronological analysis of the vertically placed beams produced a terminus post quem, which is far too early to be of any help in the discussion on the gunpowder-magazine. The technical differences between the inner and outer wall of the gunpowder-magazine suggest at least 2 phases for this building. The above-mentioned ceramics consist of redwares, Rhenish stone- wares a.o. Raeren, maiolicas, Weser slipwares, olive jars from Seville and some whitewares with green or yellow glaze. The archaeological material from the open- air rainwater reservoir in the Spanish bastion dates from the 2nd half of the 17th/1st half of the 19th century but mainly from the 18th century (figs. 16-32). The collection of ceramics from this context is largely dominated by tablewares. Among these stonewares are nearly missing and replaced by faience, china and industrial white- wares (pearl and cream wares). Maiolica has been nearly completely replaced by faience. Maiolicas remain in fact only important as wall-tiles. The collection contains some olive jars from Seville, a bowl from Dèsvres and a few products from Beauvais. The collection of china mainly consists of cups and small dishes in blue and white china. The china has been brought to Ostend in great quantities in the 18th century, first by the Ostend Company and later by mariners from Ostend in Foreign Service, mainly as ship's ballast. Besides ceramics this context also produced several finds in leather, glass, stone and metal. The leather finds mainly consist of shoes. The glass collection is largely dominated by cylindrical and globular bottles of which one was still intact including its cork (fig. 26: 1). Metal is represented by 22 cast iron cannon balls (fig. 28) and by a standard measure for bottles from an unidentified town inspector of measures and weights of Ostend with GS initials (fig. 27: 8). Small quantities of animal remains were found dispersed over many contexts within the site's stratigraphy. Only three of them are meaningful: a deposit found under the floor of the gunpowder-magazine (table 1: context A), an assemblage excavated in leveling layers within the Peckels bastion (table 1: context B), and material found in the water reservoir in the Spanish bastion (table 1: context C). All connections consisted of larger material; sieved samples did not yield meaningful numbers of smaller animal remains. Context A dates from the second half of the 16th to the first half of the 17th century and consists of consumption refuse: marine molluscs, marine fish bones, bird bone and the remains of cattle, sheep and pig. Context B is contemporaneous to context A and also represents consumption refuse with a similar composition. Remarkable are only a series of vertebrae of a large specimen of ling, a fish that must have been caught in northern waters, and a number of skeletal elements of a gurnard species. Context C has a younger date (second half of the 17th century to the first half of the 19th century) and has a mixed origin in terms of the taphonomy of the animal remains. Not only consumption refuse is present but also parts of the skeletons of at least four dogs and a horse. It is possible that all three contexts represent secondary refuse; in any case their provenance remains unknown. The material certainly has limited value for the interpretation of former consumption patterns. A feature of special interest is the presence of a few cowrie shells. Several aspects of the material culture reflect the maritime character of the town: the presence of several imports such as olive jars from Seville and specific objects as a token in lead (fig. 13: 16) probably used by skippers for the payment of fees and/or tolls. The presence of an important percentage of china and of some cowrie shells is probably related to the activities of the Ostend Company in the l8th century. The pottery discovered from both contexts (2nd half 16th century/ 1 st half 17th century and 2nd half 17th century/ 1st half 19th century) follows the general trends described for post-medieval Flanders

Can Child Care Workers Contribute to the Early Detection of Autism Spectrum Disorders? A Comparison Between Screening Instruments with Child Care Workers Versus Parents as Informants

Several screening instruments for ASD in young children were developed during the last decades. Only few studies compare the discriminative power of these instruments in the same sample. In particular comparisons of instruments that use different informants are scarce in young children. The current study compared the discriminant ability of the Checklist for Early Signs of Developmental Disorders (CESDD) filled out by child care workers with that of frequently used parent questionnaires in a sample of 357 children between 5.57 and 48.13 months old who showed signs of ASD or language delay. The discriminant power of the CESDD was as good as that of parent questionnaires. Therefore, inclusion of child care workers in the early detection of ASD seems promising

Variant Ataxia Telangiectasia: Clinical and Molecular Findings and Evaluation of Radiosensitive Phenotypes in a Patient and Relatives

Variant ataxia telangiectasia (A-T) may be an underdiagnosed entity. We correlate data from radiosensitivity and kinase assays with clinical and molecular data from a patient with variant A-T and relatives. The coding region of ATM was sequenced. To evaluate the functional effect of the mutations, we performed kinase assays and developed a novel S-G2 micronucleus test. Our patient presented with mild dystonia, moderately dysarthric speech, increased serum alpha-fetoprotein but no ataxia nor telangiectasias, no nystagmus or oculomotor dyspraxia. She has a severe IgA deficiency, but does not have recurrent infections. She is compound heterozygote for ATM c.8122G > A (p.Asp2708Asn) and c.8851-1G > T, leading to in frame loss of 63 nucleotides at the cDNA level. A trace amount of ATM protein is translated from both alleles. Residual kinase activity is derived only from the p.Asp2708Asn allele. The conventional G0 micronucleus test, based on irradiation of resting lymphocytes, revealed a radiosensitive phenotype for the patient, but not for the heterozygous relatives. As ATM is involved in homologous recombination and G2/M cell cycle checkpoint, we optimized an S-G2 micronucleus assay, allowing to evaluate micronuclei in lymphocytes irradiated in the S and G2 phases. This test showed increased radiosensitivity for both the patient and the heterozygous carriers. Intriguingly, heterozygous carriers of c.8851-1G > T (mutation associated with absence of kinase activity) showed a stronger radiosensitive phenotype with this assay than heterozygous carriers of p.Asp2708Asn (mutation associated with residual kinase activity). The modified S-G2 micronucleus assay provided phenotypic insight into complement the diagnosis of this atypical A-T patient