Slow-light enhanced light-matter interactions with applications to gas sensing

Optical gas detection in microsystems is limited by the short micron scale optical path length available. Recently, the concept of slow-light enhanced absorption has been proposed as a route to compensate for the short path length in miniaturized absorption cells. We extend the previous perturbation theory to the case of a Bragg stack infiltrated by a spectrally strongly dispersive gas with a narrow and distinct absorption peak. We show that considerable signal enhancement is possible. As an example, we consider a Bragg stack consisting of PMMA infiltrated by O2. Here, the required optical path length for visible to near-infrared detection (~760 nm) can be reduced by at least a factor of 10^2, making a path length of 1 mm feasible. By using this technique, optical gas detection can potentially be made possible in microsystems

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Analysis of shared heritability in common disorders of the brain

Paroxysmal Cerebral Disorder

Die Ultrastruktur der Neointima arterieller Gefässprothesen aus Lyophilisierter menschlicher dura. Langzeitergebnisse bei Hunden.

5 aus lyophilisierter menschlicher Dura (LMD) hergestellte und Hunden implantierte Arterienprothesen wurden nach 4, 5 1/2, 13, 43 und 46 Monaten entnommen und elektronenmikroskopisch untersucht. Die Neointima aller Implantate bestand aus Pseudo-Endothelzellen, Fibrozyten und Kollagenfibrillen. 43 und 46 Monate nach Implantation waren außerdem glatte Muskelzellen und elastische Mikrofibrillen in der Neointima vorhanden. Diese entsprach somit in ihrer Zusammensetzung im wesentlichen der Neointima von Kunststoff- und Kollagen-Kunststoff-Arterienprothesen. Die klinische Erprobung von LMD-Implantaten als arterieller Gefäßersatz ist jedoch wegen degenerativer Wandveränderungen in den Prothesen mit fast vierjähriger Verweildauer vorerst noch zu früh.   &nbsp

VPF-Schaeumverfahren zur Herstellung von FCKW-freien PUR-Weichschaeumen Abschlussbericht

In an enclosed plant, flexible polyurethane foam will be produced under defined reduced pressure. With this procedural measure, it is possible to produce low density flexible polyurethan foam without physical blowing agent. (orig.)SIGLEAvailable from TIB Hannover: RO 2148(2068) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany); Umweltbundesamt, Berlin (Germany)DEGerman

Forschungs- und Entwicklungsarbeiten ueber alternative Methoden zur Massenentsaeuerung von Buechern und Archivalien Abschlussbericht

As a result of research and development work carried out in connection with the conduction of a pilot plant and a demonstration plant in Leipzig, a new concept for book deacidification is described. Paper neutralization is achieved by treatment with Ti/Mg alkoxides dissolved in liquid hexamethyldisiloxane. Additional alternative neutralization experiments with aqueous aerosols and acid extraction by carbon dioxide yielded no satisfying results. Restrengthening of paper samples could be achieved by bifunctional isocyanates, however, the isocyanates proved to be not compatible with the Ti/Mg alkoxides. (WEN)Available from TIB Hannover: RR 2035(67.912-1)+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman

Wissenschaftliche Arbeiten zur Ermittlung der optimalen Bedingungen fuer die Langzeitlagerung von archivalischem und bibliothekarischem Sammelgut. Stufe 2 Abschlussbericht

The influence of moisture content and temperature on the aging rate of unbound, non-loaded modern and historic papers has been studied under isothermal conditions as well as under cyclic temperature changes at different moisture contents. Based on the established hypothesis that aging is caused by mechanical stress within the paper sheets, and that this stress is induced by temperature differences, proposals for storage conditions are derived: a low storage temperature should be maintained, and at the same time the temperature difference between storage and user rooms should be as small as possible. For harmonization of both contradictionary rules, quantitative data have to be collected to enable individual storage optimization. (WEN)SIGLEAvailable from TIB Hannover: RR 2035(67.787-1)+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany); Deutsches Bibliotheksinstitut (DBI), Berlin (Germany)DEGerman

Entwicklung einer Abgasreinigungsanlage zur Verminderung geruchsintensiver und kanzerogener Luftverunreinigung bei Anlagen zur Aushaertung von Reibbelaegen

SIGLETIB: RN 8908 (87-020) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman