Parental Reflective Functioning correlates to brain activation in response to video-stimuli of mother–child dyads: Links to maternal trauma history and PTSD

Parental Reflective Functioning is a parent's capacity to infer mental states in herself and her child. Parental Reflective Functioning is linked to the quality of parent-child attachment and promotes parent-child mutual emotion regulation. We examined neural correlates of parental reflective functioning and their relationship to physical abuse. Participants were mothers with (n = 26) and without (n = 22) history of childhood physical abuse. Parental reflective functioning was assessed by coding transcripts of maternal narrative responses on interviews. All mothers also underwent magnetic resonance imaging while watching video clips of children during mother-child separation and play. Parental reflective functioning was significantly lower among mothers with histories of childhood physical abuse. When mothers without history of childhood physical abuse watched scenes of separation versus play, brain activation was positively correlated with parental reflective functioning in the ventromedial prefrontal cortex, and negatively associated with the dorsolateral prefrontal cortex and insula. These associations were not present when limiting analyses to mothers reporting abuse histories. Regions subserving emotion regulation and empathy were associated with parental reflective functioning; yet these regions were not featured in maltreated mothers. These data suggest that childhood physical abuse exposure may alter the psychobiology that is linked to emotional comprehension and regulation

Sloan Digital Sky Survey Spectroscopic Lens Search. I. Discovery of Intermediate-Redshift Star-Forming Galaxies Behind Foreground Luminous Red Galaxies

We present a catalog of 49 spectroscopic strong gravitational lens candidates selected from a Sloan Digital Sky Survey sample of 50996 luminous red galaxies. Potentially lensed star-forming galaxies are detected through the presence of background oxygen and hydrogen nebular emission lines in the spectra of these massive foreground galaxies. This multiline selection eliminates the ambiguity of single-line identification and provides a very promising sample of candidate galaxy-galaxy lens systems at low to intermediate redshift, with foreground redshifts ranging from 0.16 to 0.49 and background redshifts from 0.25 to 0.81. Any lenses confirmed within our sample would be important new probes of early-type galaxy mass distributions, providing complementary constraints to those obtained from currently known lensed high-redshift quasars.Comment: 23 pages; to appear in The Astronomical Journal, 2004 April. Version with full-resolution figures available at http://web.mit.edu/bolton/www/speclens.ps.gz (PostScript) or http://web.mit.edu/bolton/www/speclens.pdf (PDF

On the complex and dimensional relationship of maternal PTSD during early childhood and child outcomes at school-age.

Several studies have shown associations between maternal interpersonal violence-related posttraumatic stress disorder (PTSD), child mental health problems, and impaired socioemotional development. However, the existing literature lacks evidence linking constellations of risk factors such as maternal interpersonal-violence-related PTSD, psychopathology, and interactive behavior with toddlers and outcome measures at school-age. This study involved a prospective, longitudinal investigation of 62 mothers and examined the relationship between maternal variables measured when children were in early childhood (mean age 27 months), and child outcomes when children were school-age (age mean = 83.2 months) while retaining a focus on the context of maternal PTSD. To identify and weigh associated dimensions comparatively, we employed sparse canonical correlation analysis (sCCA) aimed at associating dimensions of a dataset of 20 maternal variables in early childhood with that of more than 20 child outcome variables (i.e., child psychopathology, life-events, and socioemotional skills) at school-age. Phase 1 variables with the highest weights were those of maternal psychopathology: PTSD, depressive and dissociative symptoms, and self-report of parental stress. The highest weighted Phase 2 child outcome measures were those of child psychopathology: PTSD, anxiety, and depressive symptoms as well as peer bullying and victimization. sCCA revealed that trauma-related concepts in mothers were significantly and reliably associated with child psychopathology and other indicators of risk for intergenerational transmission of violence and victimization. The results highlight the dimensional and multifaceted nature-both for mothers as well as children-of the intergenerational transmission of violence and associated psychopathology

The relation of general socio-emotional processing to parenting specific behavior: A study of mothers with and without posttraumatic stress disorder

Socio-emotional information processing during everyday human interactions has been assumed to translate to social-emotional information processing when parenting a child. Yet, few studies have examined whether this is indeed the case. This study aimed to improve on this by connecting the functional neuroimaging data when seeing socio-emotional interactions that are not parenting specific to observed maternal sensitivity. The current study considered 45 mothers of small children (12–42 months of age). It included healthy controls (HC) and mothers with interpersonal violence-related posttraumatic stress disorder (IPV-PTSD), as well as mothers without PTSD, both with and without IPV exposure. We found that anterior cingulate cortex (ACC) and ventromedial prefrontal cortex (vmPFC) activity correlated negatively with observed maternal sensitivity when mothers watched videos of menacing vs. prosocial adult male–female interactions. This relationship was independent of whether mothers were HC or had IPV-PTSD. We also found dorsolateral prefrontal cortex (dlPFC) activity to be correlated negatively with maternal sensitivity when mothers watched any kind of arousing adult interactions. With regards to ACC and vmPFC activity, we interpret our results to mean that the ease of general emotional information integration translates to parenting-specific behavior. Our dlPFC activity findings support the idea that the efficiency of top-down control of socio-emotional processing in non-parenting specific contexts may be predictive of parenting behavior

Methylation of NR3C1 is related to maternal PTSD, parenting stress and maternal medial prefrontal cortical activity in response to child separation among mothers with histories of violence exposure.

Prior research has shown that mothers with Interpersonal violence-related posttraumatic stress disorder (IPV-PTSD) report greater difficulty in parenting their toddlers. Relative to their frequent early exposure to violence and maltreatment, these mothers display dysregulation of their hypothalamic pituitary adrenal axis (HPA-axis), characterized by hypocortisolism. Considering methylation of the promoter region of the glucocorticoid receptor gene NR3C1 as a marker for HPA-axis functioning, with less methylation likely being associated with less circulating cortisol, the present study tested the hypothesis that the degree of methylation of this gene would be negatively correlated with maternal IPV-PTSD severity and parenting stress, and positively correlated with medial prefrontal cortical (mPFC) activity in response to video-stimuli of stressful versus non-stressful mother-child interactions. Following a mental health assessment, 45 mothers and their children (ages 12-42 months) participated in a behavioral protocol involving free-play and laboratory stressors such as mother-child separation. Maternal DNA was extracted from saliva. Interactive behavior was rated on the CARE-Index. During subsequent fMRI scanning, mothers were shown films of free-play and separation drawn from this protocol. Maternal PTSD severity and parenting stress were negatively correlated with the mean percentage of methylation of NR3C1. Maternal mPFC activity in response to video-stimuli of mother-child separation versus play correlated positively to NR3C1 methylation, and negatively to maternal IPV-PTSD and parenting stress. Among interactive behavior variables, child cooperativeness in play was positively correlated with NR3C1 methylation. Thus, the present study is the first published report to our knowledge, suggesting convergence of behavioral, epigenetic, and neuroimaging data that form a psychobiological signature of parenting-risk in the context of early life stress and PTSD

SDSS J092455.87+021924.9: an Interesting Gravitationally Lensed Quasar from the Sloan Digital Sky Survey

We report the discovery of a new gravitationally lensed quasar from the Sloan Digital Sky Survey, SDSS J092455.87+021924.9 (SDSS J0924+0219). This object was selected from among known SDSS quasars by an algorithm that was designed to select another known SDSS lensed quasar (SDSS 1226-0006A,B). Five separate components, three of which are unresolved, are identified in photometric follow-up observations obtained with the Magellan Consortium's 6.5m Walter Baade telescope at Las Campanas Observatory. Two of the unresolved components (designated A and B) are confirmed to be quasars with z=1.524; the velocity difference is less than 100 km sec^{-1} according to spectra taken with the W. M. Keck Observatory's Keck II telescope on Mauna Kea. A third stellar component, designated C, has the colors of a quasar with redshift similar to components A and B. The maximum separation of the point sources is 1.78". The other two sources, designated G and D, are resolved. Component G appears to be the best candidate for the lensing galaxy. Although component D is near the expected position of the fourth lensed component in a four image lens system, its properties are not consistent with being the image of a quasar at z~1.5. Nevertheless, the identical redshifts of components A and B and the presence of component C strongly suggest that this object is a gravitational lens. Our observations support the idea that a foreground object reddens the fourth lensed component and that another unmodeled effect (such as micro- or milli-lensing) demagnificates it, but we cannot rule out the possibility that SDSS0924+0219 is an example of the relatively rare class of ``three component'' lens systems.Comment: 24 pages, 6 figures, accepted by A

The velocity dispersion function of early-type galaxies

The distribution of early-type galaxy velocity dispersions, phi(sigma), is measured using a sample drawn from the SDSS database. Its shape differs significantly from that which one obtains by simply using the mean correlation between luminosity, L, and velocity dispersion, sigma, to transform the luminosity function into a velocity function: ignoring the scatter around the mean sigma-L relation is a bad approximation. An estimate of the contribution from late-type galaxies is also made, which suggests that phi(sigma) is dominated by early-type galaxies at velocities larger than ~ 200 km/s.Comment: Minor changes, matches version to appear in ApJ, 1 September 200

SDSS J0246-0825: A New Gravitationally Lensed Quasar from the Sloan Digital Sky Survey

We report the discovery of a new two-image gravitationally lensed quasar, SDSS J024634.11-082536.2 (SDSS J0246-0825). This object was selected as a lensed quasar candidate from the Sloan Digital Sky Survey (SDSS) by the same algorithm that was used to discover other SDSS lensed quasars (e.g., SDSS J0924+0219). Multicolor imaging with the Magellan Consortium's Walter Baade 6.5-m telescope and the spectroscopic observations using the W. M. Keck Observatory's Keck II telescope confirm that SDSS J0246-0825 consists of two lensed images ($\Delta{\theta}=$1\farcs04) of a source quasar at z=1.68. Imaging observations with the Keck telescope and the Hubble Space Telescope reveal an extended object between the two quasar components, which is likely to be a lensing galaxy of this system. From the absorption lines in the spectra of quasar components and the apparent magnitude of the galaxy, combined with the expected absolute magnitude from the Faber-Jackson relation, we estimate the redshift of the lensing galaxy to be z=0.724. A highly distorted ring is visible in the Hubble Space Telescope images, which is likely to be the lensed host galaxy of the source quasar. Simple mass modeling predicts the possibility that there is a small (faint) lensing object near the primary lensing galaxy.Comment: 30 pages, 12 figures, The Astronomical Journal accepte