Spin-squared Hamiltonian of next-to-leading order gravitational interaction

The static, i.e., linear momentum independent, part of the next-to-leading order (NLO) gravitational spin(1)-spin(1) interaction Hamiltonian within the post-Newtonian (PN) approximation is calculated from a 3-dim. covariant ansatz for the Hamilton constraint. All coefficients in this ansatz can be uniquely fixed for black holes. The resulting Hamiltonian fits into the canonical formalism of Arnowitt, Deser, and Misner (ADM) and is given in their transverse-traceless (ADMTT) gauge. This completes the recent result for the momentum dependent part of the NLO spin(1)-spin(1) ADM Hamiltonian for binary black holes (BBH). Thus, all PN NLO effects up to quadratic order in spin for BBH are now given in Hamiltonian form in the ADMTT gauge. The equations of motion resulting from this Hamiltonian are an important step toward more accurate calculations of templates for gravitational waves.Comment: REVTeX4, 10 pages, v2: minor improvements in the presentation, v3: added omission in Eq. (4) and corrected coefficients in the result, Eq. (9); version to appear in Phys. Rev.

Developing theory-informed interventions to implement evidence into practice: a systematic approach using the Theoretical Domains Framework

Background: There is little systematic operational guidance about how best to develop complex interventions to reduce the gap between practice and evidence. This article is one in a series of articles documenting the development and use of the Theoretical Domains Framework (TDF) to advance the science of implementation research. Methods: The intervention was developed considering three main components: theory, evidence, and practical issues. We used a four-step approach, consisting of guiding questions, to direct the choice of the most appropriate components of an implementation intervention: Who needs to do what, differently? Using a theoretical framework, which barriers and enablers need to be addressed? Which intervention components (behaviour change techniques and mode(s) of delivery) could overcome the modifiable barriers and enhance the enablers? And how can behaviour change be measured and understood? Results: A complex implementation intervention was designed that aimed to improve acute low back pain management in primary care. We used the TDF to identify the barriers and enablers to the uptake of evidence into practice and to guide the choice of intervention components. These components were then combined into a cohesive intervention. The intervention was delivered via two facilitated interactive small group workshops. We also produced a DVD to distribute to all participants in the intervention group. We chose outcome measures in order to assess the mediating mechanisms of behaviour change. Conclusions: We have illustrated a four-step systematic method for developing an intervention designed to change clinical practice based on a theoretical framework. The method of development provides a systematic framework that could be used by others developing complex implementation interventions. While this framework should be iteratively adjusted and refined to suit other contexts and settings, we believe that the four-step process should be maintained as the primary framework to guide researchers through a comprehensive intervention development process

The role of premagmatic rifting in shaping a volcanic continental margin: An example from the Eastern North American Margin

Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 125(11),(2020): e2020JB019576, doi:10.1029/2020JB019576.Both magmatic and tectonic processes contribute to the formation of volcanic continental margins. Such margins are thought to undergo extension across a narrow zone of lithospheric thinning (~100 km). New observations based on existing and reprocessed data from the Eastern North American Margin contradict this hypothesis. With ~64,000 km of 2‐D seismic data tied to 40 wells combined with published refraction, deep reflection, receiver function, and onshore drilling efforts, we quantified along‐strike variations in the distribution of rift structures, magmatism, crustal thickness, and early post‐rift sedimentation under the shelf of Baltimore Canyon Trough (BCT), Long Island Platform, and Georges Bank Basin (GBB). Results indicate that BCT is narrow (80–120 km) with a sharp basement hinge and few rift basins. The seaward dipping reflectors (SDR) there extend ~50 km seaward of the hinge line. In contrast, the GBB is wide (~200 km), has many syn‐rift structures, and the SDR there extend ~200 km seaward of the hinge line. Early post‐rift depocenters at the GBB coincide with thinner crust suggesting “uniform” thinning of the entire lithosphere. Models for the formation of volcanic margins do not explain the wide structure of the GBB. We argue that crustal thinning of the BCT was closely associated with late syn‐rift magmatism, whereas the broad thinning of the GBB segment predated magmatism. Correlation of these variations to crustal terranes of different compositions suggests that the inherited rheology determined the premagmatic response of the lithosphere to extension.Financial support was provided by the U.S. Department of Energy Award DE‐FE‐0026087 to Battelle Memorial Institute under the “Mid‐Atlantic U.S. Offshore Carbon Storage Resource Assessment” Project.2021-04-1

Structural expression of a fading rift front: a case study from the Oligo-Miocene Irbid rift of northwest Arabia

Not all continental rifts mature to form a young ocean. The mechanism and duration of their cessation depend on the crustal structure, modifications in plate kinematics, lithospheric thermal response, or the intensity of subcrustal flow (e.g., plume activity). The cessation is recorded in the structure and stratigraphy of the basins that develop during the rifting process. This architecture is lost due to younger tectonic inversion, severe erosion, or even burial into greater depths that forces their detection by low-resolution geophysical imaging. The current study focuses on a uniquely preserved Oligo-Miocene rift that was subsequently taken over by a crossing transform fault system and, mostly due to that, died out. We integrate all geological, geophysical, and previous study results from across the southern Galilee to unravel the structural development of the Irbid failing rift in northwest Arabia. Despite tectonic, magmatic, and geomorphologic activity postdating the rifting, its subsurface structure northwest of the Dead Sea fault is preserved at depths of up to 1&thinsp;km. Our results show that a series of basins subsided at the rift front, i.e., rift termination, across the southern Galilee. We constrain the timing and extent of their subsidence into two main stages based on facies analysis and chronology of magmatism. Between 20 and 9&thinsp;Ma grabens and half-grabens subsided within a larger releasing jog, following a NW direction of a deeper presumed principal displacement zone. The basins continued to subside until a transition from the transtensional Red Sea to the transpressional Dead Sea stress regime occurred. With the transition, the basins ceased to subside as a rift, while the Dead Sea fault split the jog structure. Between 9 and 5&thinsp;Ma basin subsidence accentuated and an uplift of their margins accompanied their overall elongation to the NNE. Our study provides for the first time a structural as well as tectonic context for the southern Galilee basins. Based on this case study we suggest that the rift did not fail but rather faded and was taken over by a more dominant stress regime. Otherwise, these basins of a failing rift could have simply died out peacefully.</p

Good physicians from the perspective of their patients

BACKGROUND: It is not currently known what is the patient's viewpoint of a "good" physician. We set out to define patient's priorities regarding different physician's attributes in 3 domains important in medical care. METHODS: Patients hospitalized or attending clinics at a large teaching hospital selected the 4 attributes that they considered most important out of 21 listed arbitrarily in a questionnaire. The questionnaire included 7 items each in the domains of patient autonomy, professional expertise and humanism. RESULTS: Participating patients (n = 445, mean age 57.5 ± 16 years) selected professional expertise (50%), physician's patience and attentiveness (38% and 30%, respectively), and informing the patient, representing the patient's interests, being truthful and respecting patient's preferences (25–36% each) as the most essential attributes. Patient's selections were not significantly influenced by different demographic or clinical background. Selections of attributes in the domain of patient's autonomy were significantly more frequent and this was the preferred domain for 31% and as important as another domain for 16% – significantly more than the domain of professional expertise (P = 0.008), and much more than the domain of humanism and support (P < 0.0005). CONCLUSIONS: Patients studied want their physicians to be highly professional and expert clinicians and show humaneness and support, but their first priority is for the physician to respect their autonomy

Mechanics of extended masses in general relativity

The "external" or "bulk" motion of extended bodies is studied in general relativity. Compact material objects of essentially arbitrary shape, spin, internal composition, and velocity are allowed as long as there is no direct (non-gravitational) contact with other sources of stress-energy. Physically reasonable linear and angular momenta are proposed for such bodies and exact equations describing their evolution are derived. Changes in the momenta depend on a certain "effective metric" that is closely related to a non-perturbative generalization of the Detweiler-Whiting R-field originally introduced in the self-force literature. If the effective metric inside a self-gravitating body can be adequately approximated by an appropriate power series, the instantaneous gravitational force and torque exerted on it is shown to be identical to the force and torque exerted on an appropriate test body moving in the effective metric. This result holds to all multipole orders. The only instantaneous effect of a body's self-field is to finitely renormalize the "bare" multipole moments of its stress-energy tensor. The MiSaTaQuWa expression for the gravitational self-force is recovered as a simple application. A gravitational self-torque is obtained as well. Lastly, it is shown that the effective metric in which objects appear to move is approximately a solution to the vacuum Einstein equation if the physical metric is an approximate solution to Einstein's equation linearized about a vacuum background.Comment: 39 pages, 2 figures; fixed equation satisfied by the Green function used to construct the effective metri

Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin: a case report

<p>Abstract</p> <p>Background</p> <p>Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin is a rare but serious complication of the use of Nitrofurantoin.</p> <p>Case presentation</p> <p>A 72 year old woman taking Nitrofurantoin for recurrent urinary sepsis presenting with breathlessness abdominal discomfort and abnormal liver function tests is described. Drug toxicity secondary to Nitrofurantoin was diagnosed. Cessation of the drug and a course of steroids markedly improved her condition.</p> <p>Discussion</p> <p>We review the drug reactions associated with Nitrofurantoin and suggest an alternative treatment strategy for recurrent urinary sepsis.</p> <p>Conclusion</p> <p>Adverse drug reactions are an important cause of concomitant lung and liver toxicity and the mainstay of treatment is drug withdrawal.</p

Post-Newtonian Gravitational Radiation

1 Introduction 2 Multipole Decomposition 3 Source Multipole Moments 4 Post-Minkowskian Approximation 5 Radiative Multipole Moments 6 Post-Newtonian Approximation 7 Point-Particles 8 ConclusionComment: 46 pages, in Einstein's Field Equations and Their Physical Implications, B. Schmidt (Ed.), Lecture Notes in Physics, Springe

Motion in classical field theories and the foundations of the self-force problem

This article serves as a pedagogical introduction to the problem of motion in classical field theories. The primary focus is on self-interaction: How does an object's own field affect its motion? General laws governing the self-force and self-torque are derived using simple, non-perturbative arguments. The relevant concepts are developed gradually by considering motion in a series of increasingly complicated theories. Newtonian gravity is discussed first, then Klein-Gordon theory, electromagnetism, and finally general relativity. Linear and angular momenta as well as centers of mass are defined in each of these cases. Multipole expansions for the force and torque are then derived to all orders for arbitrarily self-interacting extended objects. These expansions are found to be structurally identical to the laws of motion satisfied by extended test bodies, except that all relevant fields are replaced by effective versions which exclude the self-fields in a particular sense. Regularization methods traditionally associated with self-interacting point particles arise as straightforward perturbative limits of these (more fundamental) results. Additionally, generic mechanisms are discussed which dynamically shift --- i.e., renormalize --- the apparent multipole moments associated with self-interacting extended bodies. Although this is primarily a synthesis of earlier work, several new results and interpretations are included as well.Comment: 68 pages, 1 figur

CompaGB: An open framework for genome browsers comparison

<p>Abstract</p> <p>Background</p> <p>Tools to visualize and explore genomes hold a central place in genomics and the diversity of genome browsers has increased dramatically over the last few years. It often turns out to be a daunting task to compare and choose a well-adapted genome browser, as multidisciplinary knowledge is required to carry out this task and the number of tools, functionalities and features are overwhelming.</p> <p>Findings</p> <p>To assist in this task, we propose a community-based framework based on two cornerstones: (i) the implementation of industry promoted software qualification method (QSOS) adapted for genome browser evaluations, and (ii) a web resource providing numerous facilities either for visualizing comparisons or performing new evaluations. We formulated 60 criteria specifically for genome browsers, and incorporated another 65 directly from QSOS's generic section. Those criteria aim to answer versatile needs, ranging from a biologist whose interest primarily lies into user-friendly and informative functionalities, a bioinformatician who wants to integrate the genome browser into a wider framework, or a computer scientist who might choose a software according to more technical features. We developed a dedicated web application to enrich the existing QSOS functionalities (weighting of criteria, user profile) with features of interest to a community-based framework: easy management of evolving data, user comments...</p> <p>Conclusions</p> <p>The framework is available at <url>http://genome.jouy.inra.fr/CompaGB</url>. It is open to anyone who wishes to participate in the evaluations. It helps the scientific community to (1) choose a genome browser that would better fit their particular project, (2) visualize features comparatively with easily accessible formats, such as tables or radar plots and (3) perform their own evaluation against the defined criteria. To illustrate the CompaGB functionalities, we have evaluated seven genome browsers according to the implemented methodology. A summary of the features of the compared genome browsers is presented and discussed.</p