Surveillance and Outbreak Response Management System (SORMAS) to support the control of the Ebola virus disease outbreak in West Africa

In the context of controlling the current outbreak of Ebola virus disease (EVD), the World Health Organization claimed that ‘critical determinant of epidemic size appears to be the speed of implementation of rigorous control measures’, i.e. immediate follow-up of contact persons during 21 days after exposure, isolation and treatment of cases, decontamination, and safe burials. We developed the Surveillance and Outbreak Response Management System (SORMAS) to improve efficiency and timeliness of these measures. We used the Design Thinking methodology to systematically analyse experiences from field workers and the Ebola Emergency Operations Centre (EOC) after successful control of the EVD outbreak in Nigeria. We developed a process model with seven personas representing the procedures of EVD outbreak control. The SORMAS system architecture combines latest In-Memory Database (IMDB) technology via SAP HANA (in-memory, relational database management system), enabling interactive data analyses, and established SAP cloud tools, such as SAP Afaria (a mobile device management software). The user interface consists of specific front-ends for smartphones and tablet devices, which are independent from physical configurations. SORMAS allows real-time, bidirectional information exchange between field workers and the EOC, ensures supervision of contact follow-up, automated status reports, and GPS tracking. SORMAS may become a platform for outbreak management and improved routine surveillance of any infectious disease. Furthermore, the SORMAS process model may serve as framework for EVD outbreak modelling

Disease- and sex-specific differences in patients with heart valve disease: a proteome study

Pressure overload in patients with aortic valve stenosis and volume overload in mitral valve regurgitation trigger specific forms of cardiac remodeling; however, little is known about similarities and differences in myocardial proteome regulation. We performed proteome profiling of 75 human left ventricular myocardial biopsies (aortic stenosis = 41, mitral regurgitation = 17, and controls = 17) using high-resolution tandem mass spectrometry next to clinical and hemodynamic parameter acquisition. In patients of both disease groups, proteins related to ECM and cytoskeleton were more abundant, whereas those related to energy metabolism and proteostasis were less abundant compared with controls. In addition, disease group-specific and sex-specific differences have been observed. Male patients with aortic stenosis showed more proteins related to fibrosis and less to energy metabolism, whereas female patients showed strong reduction in proteostasis-related proteins. Clinical imaging was in line with proteomic findings, showing elevation of fibrosis in both patient groups and sex differences. Disease- and sex-specific proteomic profiles provide insight into cardiac remodeling in patients with heart valve disease and might help improve the understanding of molecular mechanisms and the development of individualized treatment strategies

A Review of RFID in Supply Chain Management: 2000–2015

This paper presents a systematic literature review of papers that were published in academic journals on the applications of radio frequency identification (RFID) in supply chain management between the years 2000 and 2015. As the literature on RFID is not confined to specific disciplines or repositories, this paper proposes a discipline-based framework for classifying RFID literature. Five main classification categories are used in this paper: technology, supply chain management, research methodology, application industries, and social aspects. The paper then focuses on the category of supply chain management and reviews 1187 articles that were published between 2000 and 2015 in rated journals. All the papers reviewed are further classified into eight subclasses under this category of supply chain management. The review yields useful insights into the anatomy of RFID literature in supply chain management, enhances evidence-based knowledge, and contributes to informing practice, policymaking and future research. The review reveals that even presently, despite technical and cost challenges, enormous potential exists for the application of RFID in several areas of supply chain management and the prospects are likely to grow into the future. Since RFID solutions have emerged primarily over only the past 20 years, significant research opportunities exist and would need to be addressed to continue to support the technology’s maturation, evaluation, adoption, implementation, and diffusion