S-D logic-informed customer engagement: Integrative framework, revised fundamental propositions, and application to CRM

Advance online in 2016</p

Voiceconomics

This chapter discusses the fundamental changes in today’s economic rules with the rise of voicesumers in the digital world. The chapter explains how influencers and followers create economic value with their voice in the social media. The value created by number of followers and the quality of voice of influencers are all discussed in light of the currently developing digital consumer behavior literature. The economic value of tone of voice such as human-like and business-like voices and their impact on consumer voice engagements are also discussed with a new theoretical framework. Thus, the study provided insights on how consumer voice is reshaping market valuation processes through transforming production and consumption of consumer voice

Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359

The cyclic depsipeptide FR900359 (FR), isolated from the tropical plant Ardisia crenata, is a strong and selective inhibitor of Gq proteins, making it an indispensable pharmacological tool to study Gq-related processes, as well as a promising drug candidate. Gq inhibition is a novel mode of action for defense chemicals and crucial for the ecological function of FR, as shown by in vivo experiments in mice, its affinity to insect Gq proteins, and insect toxicity studies. The uncultured endosymbiont of A. crenata was sequenced, revealing the FR nonribosomal peptide synthetase (frs) gene cluster. We here provide a detailed model of FR biosynthesis, supported by in vitro enzymatic and bioinformatic studies, and the novel analogue AC-1, which demonstrates the flexibility of the FR starter condensation domains. Finally, expression of the frs genes in E. coli led to heterologous FR production in a cultivable, bacterial host for the first time