Comparison of Several Methods of Predicting the Pressure Loss at Altitude Across a Baffled Aircraft-Engine Cylinder

Several methods of predicting the compressible-flow pressure loss across a baffled aircraft-engine cylinder were analytically related and were experimentally investigated on a typical air-cooled aircraft-engine cylinder. Tests with and without heat transfer covered a wide range of cooling-air flows and simulated altitudes from sea level to 40,000 feet. Both the analysis and the test results showed that the method based on the density determined by the static pressure and the stagnation temperature at the baffle exit gave results comparable with those obtained from methods derived by one-dimensional-flow theory. The method based on a characteristic Mach number, although related analytically to one-dimensional-flow theory, was found impractical in the present tests because of the difficulty encountered in defining the proper characteristic state of the cooling air. Accurate predictions of altitude pressure loss can apparently be made by these methods, provided that they are based on the results of sea-level tests with heat transfer

Results of turbojet engine operation tests using a 50-50 mixture of JP-4 and tributyl borate as the fuel

An experimental investigation was conducted on a centrifugal-type turbojet engine using a 50-50 mixture of tributyl borate and JP-4 as the fuel to determine the magnitude and the location of the boric oxide deposits in the engine as well as the effect of these deposits on the engine performance. Large deposits of boric acid formed in the combustor walls and on the turbine rotor and stator blades. The deposits had no effect on the engine thrust

Experimental investigation of coolant-flow characteristics of a sintered porous turbine blade

Local cooling-air flow rates through the walls of a sintered porous-metal turbine blade were measured at room temperature for a range of pressure drops. In order to check the validity of the correlation procedure, this procedure was used to correlate air-flow rates thorough two porous disks at temperatures up to 600 degrees F.245:00:Experimental investigation of coolant Data indicate the method permits room-temperature flow data to be used for heat-transfer work at elevated temperatures with reasonable accurach. Cooling-air flow distribution around the periphery of the test blade is presented for two internal cooling air pressures with the blade in a 1000 degrees Fahrenheit gas stream at a cascade-inlet Mach number of 0.45

Experimental investigation of the heat-transfer characteristics of an air-cooled sintered porous turbine blade

The results of a heat-transfer investigation on a transpiration-cooled turbine blade are presented. The investigation was made on a static cascade.506::Declassified December 11, 1953. Blade-peripheral wall-temperature distributions were measured and compared with the temperature distribution on a convection-cooled blade. A correlation of the blade-wall temperatures obtained at various gas temperatures and gas weight flows was made on the basis of a temperature-difference ratio. Blade-wall temperatures calculated using an approximate theory for turbulent flow are compared with the measured blade-wall tempeartures

Communication Biophysics

Contains reports on five research projects.National Institutes of Health (Grant 5 RO1 NB-05462-02)National Aeronautics and Space Administration (Grant NsG-496)National Science Foundation (Grant GP-2495)National Institutes of Health (Grant MH-04737-05

Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.

Glioblastomas represent the most aggressive glioma grade and are associated with a poor patient prognosis. The current standard of care, consisting of surgery, radiation and chemotherapy, only results in a median survival of 14 months, underscoring the importance of developing effective new therapeutic strategies. Among the challenges in treating glioblastomas are primary resistance and the rapid emergence of recurrent disease, which can result from tumor cell-intrinsic mechanisms in addition to tumor microenvironment (TME)-mediated extrinsic resistance. Using a PDGF-B-driven proneural glioma mouse model, we assessed a panel of tyrosine kinase inhibitors with different selectivity profiles. We found that PLX3397, an inhibitor of colony stimulating factor-1 receptor (CSF-1R), blocks glioma progression, markedly suppresses tumor cell proliferation and reduces tumor grade. By contrast, the multi-targeted tyrosine kinase inhibitors dovitinib and vatalanib, which directly target tumor cells, exert minimal anti-tumoral effects in vivo, despite killing glioma cells in vitro, suggesting a TME-mediated resistance mechanism may be involved. Interestingly, PLX3397 interferes with tumor-mediated education of macrophages and consequently restores the sensitivity of glioma cells to tyrosine kinase inhibitors in vivo in preclinical combination trials. Our findings thus demonstrate that microenvironmental alteration by CSF-1R blockade renders tumor cells more susceptible to receptor tyrosine kinase inhibition in a preclinical glioblastoma model, which may have important translational relevance