Apparatus for producing three-dimensional recordings of flourescence spectra Patent

Spectrophotofluorometer with 3-dimensional display to identify fluorescence spectra of carcinogenic and noncarcinogenic hydrocarbon

Making It and Breaking It: The Fate of Public Interest Commitment During Law School

A Review of Making It and Breaking It: The Fate of Public Interest Commitment During Law School by Robert V. Stove

Change in lung volume in asthma with particular reference to obesity

Over the last 20 years both asthma and obesity have increased in prevalence. What is the link? There are data to suggest that increasing obesity is a risk for the increase in prevalence of asthma. A number of mechanisms have been postulated including the effects of reduced lung volume on bronchial reactivity and mechanical changes with lower lung volumes. Other possibilities include other obesity-induced co-morbidities including gastro-oesophageal reflux. The aim of this thesis was to evaluate the link between asthma and obesity in both adult and childhood populations and to undertake experimental studies to examine the effects of changes in lung volume on bronchial reactivity. In chapter 1, the literature is reviewed. The current literature suggests that there is a link between diagnosis of asthma, new onset of asthma, symptoms of shortness of breath and wheeze. In chapter 2, data on 1997 adults in 3 population studies were analysed and the association between body mass index (BMI) and symptoms of shortness of breath and wheeze, diagnosis of asthma, medication usage for asthma, lung function and bronchial responsiveness were studied. This study showed that obesity was a risk for recent asthma (OR 2.04; 95%CI 1.02-3.76, p=0.048), symptoms of shortness of breath and wheeze (OR 2.6; 95%CI 1.46- 4.70, p=0.001), and medication usage for asthma (OR 2.53; 95%CI 1.36-4.70, p=0.003). There was a reduction in lung volume as measured by forced vital capacity (FVC), but there was no increase in bronchial hyperresponsiveness (BHR) (OR 0.87; 95% CI 0.35-2.21, p=0.78). Thus although the symptoms of asthma are increased there were no increases in BHR, despite significantly reduced lung volumes. The increase the medication usage is unlikely to have normalised the BHR, as there were ongoing symptoms suggestive of asthma. In chapter 3, data on 5993 children in 7 population studies were analysed and the association between BMI percentile and symptoms of cough, wheeze, ix diagnosis of asthma, medication usage for asthma, atopy, lung function and bronchial responsiveness was studied. After adjusting for atopy, sex, age, smoking and family history, BMI was a significant risk factor for wheeze ever (OR=1.06; 95%CI 1.01-1.10, p=0.008) and cough (OR=1.09; 95%CI 1.05-1.14, p=0.001) but not for recent asthma (OR=1.02; 95%CI 0.98-1.07 p=0.43), or bronchial hyperresponsiveness (OR=0.97; 95%CI 0.95-1.04 p=0.77). In girls, a higher BMI was significantly associated with higher prevalence of atopy (x2 trend 7.9, p=0.005), wheeze ever (x2 trend 10.4, p=0.001), and cough (x2 trend 12.3, p<0.001). These were not significant in boys. With increasing BMI in children, there was no reduction in lung volume, no increase in airway obstruction and no increase in bronchial responsiveness. In chapter 4, the hypothesis that obesity per se is associated with bronchial responsiveness was tested. Six obese women without asthma were compared to 6 non-obese women without asthma with high dose methacholine challenges to assess the bronchial responsiveness. There was no increase in bronchial responsiveness, and no difference in the position or shape of the high dose methacholine curve despite the fact that these women had reduced lung volumes associated with their obesity. In chapter 5, the hypothesis whether reduced lung volume per se would cause a change in greater mechanical effect, ie more marked airway narrowing in both non-asthmatic and asthmatic subjects was tested. Lung volumes and methacholine challenges were undertaken in the supine and erect position on different days. As expected in normal subjects there was a small reduction in lung volume on lying down, this was associated with an increase in the measure of bronchial reactivity DRR. In contrast, in asthmatics, there was no acute fall in lung volume and there were variable changes in the index of reactivity suggesting non-homogeneity in the lung function abnormality. This suggests changes in bronchial reactivity can occur without any relationship to lung volume change. These negative results suggest that lung volume changes that may occur in obesity are unlikely contributors to the apparent increase in asthma symptoms. In chapter 6, the hypothesis that the supposed increase in asthma symptoms in the obese were due to the effects of gastro-oesophageal reflux were assessed in 147 obese subjects graded for gastro-oesophageal reflux severity using manometry and gastroscopy. This study showed that subjects with increased gastro-oesophageal reflux did not have subjective increases in asthma prevalence, obstructive sleep apnoea, or snoring however they had a clear worsening of gas transfer as measured by carbon monoxide transfer suggesting a greater level of parenchymal disease. The overall results are that there is an increase of diagnosis of asthma, increase in symptoms of asthma and medication usage for the treatment of asthma in the obese. Objectively despite reductions in lung volume, there is no increase in bronchial responsiveness in this group suggesting that these symptoms are not related to true asthma, but to alternative co-morbidities associated with obesity such as gastro-oesophageal reflux. Notably gastrooesophageal reflux was not associated with increased asthma prevalence or airway obstruction. However it was associated with reduced gas transfer suggesting parenchymal disease. This suggests that the increase in symptoms of wheeze and shortness of breath in the obese should not be attributed to asthma in the absence of variable airflow limitation that is reversible spontaneously or with treatment, or with an increase in the existing bronchial hyperresponsiveness (BHR) to a variety of stimuli

Acquisition and development strategies for the Emerson College properties

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 1985.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCHJames M. McCormack and Bernard I. Schachter.M.S

Teachers’ experiences with a state-mandated kindergarten readiness assessment

This study used an embedded mixed method design to examine teachers’ experiences with a state-mandated kindergarten readiness assessment during its inaugural year. Participants were 143 kindergarten teachers from one county in a Midwestern state. In general, teachers did not perceive the Kindergarten Readiness Assessment as useful for one of its intended purposes of guiding instruction. Our findings did not indicate an adversity to assessment in general. Rather, perceptions that the new KRA was less useful for practice seemed to stem from administration issues, problems with the content assessed by the KRA, and participants’ misunderstandings regarding the purpose of the KRA. Furthermore, participants reported that the KRA took away valuable time needed to help students adjust to their first time in formal schooling and needed to create a classroom community. Implications for creating and implementing kindergarten readiness and other assessments as well as preparing teachers to use readiness assessments are discussed

Interval Laparoscopic Cholecystectomy in the Management of Acute Biliary Pancreatitis

The timing of laparoscopic cholecystectomy following an attack of acute biliary pancreatitis is controversial. The traditional approach of interval cholecystectomy has been challenged recently. The present study was designed to evaluate the benefits of interval laparoscopic cholecystectomy for patients with mild acute pancreatitis (Ranson less than 3). Nineteen patients with mild pancreatitis underwent ultrasonographic evaluation to confirm the biliary etiology. ERCP was performed in all patients on the first available endoscopy list, and endoscopic sphincterotomy was performed in two patients with calculi or dilated common bile duct on ultrasonographic examination. Medical treatment was administered and laparoscopic cholecystectomy was scheduled after 8–12 weeks to allow the inflammatory process to settle. There were no recurrent attacks of pancreatitis during this period. The degree of difficulty of the laparoscopic procedure was assessed by the presence of adhesions to the gallbladder area, difficulty of dissection in the Calot's triangle, intraoperative bleeding and the need for a drain. Six patients (31.5%) had severe adhesions, difficult dissection of the cystic duct and artery, bleeding and prolonged operating time. In two of these patients (10.5%) the procedure was converted to open cholecystectomy. In conclusion, our results suggest that postponing laparoscopic cholecystectomy in acute pancreatitis patients is not advantageous surgically and does not justify the risk of further morbidity caused by the gallbladder disease

Teachers’ perspectives on the Kindergarten Readiness Assessment in year 2: Easier to administer but what role can it play in instruction?

In this white paper, we present the results of a survey completed by teachers from across Ohio concerning their perceptions of Ohio’s Kindergarten Readiness Assessment (KRA). We examined teachers’ perceptions during year 2 of KRA implementation and compared those results to findings from a similar survey completed in year 1 of the assessment implementation. Over 3,000 Ohio public school kindergarten teachers were invited to complete the survey; of which 841 responded. In year 2, teachers reported that administering the KRA was easier, compared to year 1. However, they expressed concerns that the assessment took too long to administer, distracted from creating a classroom community, and decreased instructional time. Similar to findings from year 1, teachers reported that the assessment was not useful for guiding instruction or otherwise benefiting students; yet, teachers did report an increase in using the KRA to identify students at risk for later academic problems. In contrast to year 1, teachers seemed to better understand the purposes of the assessment although there were still some remaining misconceptions. Overall, despite some changes in perceptions, teachers continued to express concerns with the KRA’s implementation and remained unclear as to its role in improving instruction or outcomes for students

Using the new Kindergarten Readiness Assessment: What do teachers and principals think?

This white paper presents the results of a survey completed by teachers and principals in central Ohio concerning their perceptions of Ohio’s new Kindergarten Readiness Assessment (KRA) during its inaugural implementation year. All kindergarten teachers and principals in Franklin County public elementary schools were invited to complete the survey; 150 responded. Although teachers and principals generally reported using assessments, including the previous state-mandated KRA-L screening tool, to guide their instructional decisions, the majority of participants did not perceive that the KRA, in particular, was useful for guiding instruction. Moreover, teachers reported that administering the KRA took away valuable time needed to help students adjust to learning in a formal school setting and create a classroom community. Administration issues, lack of access to the data, redundancy or incompleteness of KRA data, and misconceptions about the purpose of the KRA all seemed to contribute to participants’ dissatisfaction with the KRA. Overall, it seems that teachers are not using the KRA as intended. Our findings do not indicate an adversity to assessment in general. Rather, negative perceptions and/or lack of use seem to be tied to a misunderstanding of the purpose of the KRA and administration issues

Stochastic quantum trajectories demonstrate the Quantum Zeno Effect in an open spin system

We investigate the Quantum Zeno Effect in spin 1/2, spin 1 and spin 3/2 open quantum systems undergoing Rabi oscillations. The systems interact with an environment designed to perform continuous measurements of an observable, driving the systems stochastically towards one of the eigenstates of the corresponding operator. The system-environment coupling constant represents the strength of the measurement. Stochastic quantum trajectories are generated by unravelling a Markovian Lindblad master equation using the quantum state diffusion formalism. This is regarded as a better representation of system behaviour than consideration of the averaged evolution since the latter can mask the effect of measurement. Complete positivity is maintained and thus the trajectories can be considered as physically meaningful. Increasing the measurement strength leads to greater dwell by the system in the vicinity of the eigenstates of the measured observable and lengthens the time taken by the system to return to that eigenstate, thus demonstrating the Quantum Zeno Effect. For very strong measurement, the Rabi oscillations develop into randomly occurring near-instantaneous jumps between eigenstates. The stochastic measurement dynamics compete with the intrinsic, deterministic quantum dynamics of the system, each attempting to drive the system in the Hilbert space in different ways. As such, the trajectories followed by the quantum system are heavily dependent on the measurement strength which other than slowing down and adding noise to the Rabi oscillations, changes the paths taken in spin phase space from a circular precession into elaborate figures-of-eight