RESULTS OF A QUALITATIVE SURVEY ABOUT THE AP-PLICATION OF BUSINESS INFORMATION SYSTEMS IN GERMAN CRAFT ENTERPRISES - FIRST FINDINGS OF AN ONGOING RESEARCH PROJECT

The present study shows the current status of a preliminary study about the use of business infor-mation systems (BIS) based on five exemplarily selected case studies in German craft enterprises. The question of whether similarities and differences concerning the application of information and com-munication technologies (ICT) exist in practice. For this purpose, exemplary case demonstrating the scope and usage of organizational ICT in various crafts are presented. The case studies are based on a survey of CEOs and IT managers of selected craft enterprises. Based on the results of the survey, hypotheses about the use of information technologies were derived. Based on these hypotheses, inter-dependencies of craft enterprises are presented and justified regarding the use of BIS, the actuality of the hardware, the requirements to branch-specific IT solutions, the measures taken toward data pro-tection and data security and the visibility on the Internet. As a result of the preliminary study it can be stated that a widely heterogeneous IT landscape as well as good IT competence can be found in the enterprises involved

RGB2LIDAR: Towards Solving Large-Scale Cross-Modal Visual Localization

We study an important, yet largely unexplored problem of large-scale cross-modal visual localization by matching ground RGB images to a geo-referenced aerial LIDAR 3D point cloud (rendered as depth images). Prior works were demonstrated on small datasets and did not lend themselves to scaling up for large-scale applications. To enable large-scale evaluation, we introduce a new dataset containing over 550K pairs (covering 143 km^2 area) of RGB and aerial LIDAR depth images. We propose a novel joint embedding based method that effectively combines the appearance and semantic cues from both modalities to handle drastic cross-modal variations. Experiments on the proposed dataset show that our model achieves a strong result of a median rank of 5 in matching across a large test set of 50K location pairs collected from a 14km^2 area. This represents a significant advancement over prior works in performance and scale. We conclude with qualitative results to highlight the challenging nature of this task and the benefits of the proposed model. Our work provides a foundation for further research in cross-modal visual localization.Comment: ACM Multimedia 202

Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study

Purpose: Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical and virological disease trajectories. The purpose of this work was to identify risk factors associated with need for invasive mechanical ventilation (IMV), to analyse viral kinetics in patients with and without IMV and to provide a comprehensive description of clinical course. Methods: A cohort of 168 hospitalised adult COVID-19 patients enrolled in a prospective observational study at a large European tertiary care centre was analysed. Results: Forty-four per cent (71/161) of patients required invasive mechanical ventilation (IMV). Shorter duration of symptoms before admission (aOR 1.22 per day less, 95% CI 1.10-1.37, p < 0.01) and history of hypertension (aOR 5.55, 95% CI 2.00-16.82, p < 0.01) were associated with need for IMV. Patients on IMV had higher maximal concentrations, slower decline rates, and longer shedding of SARS-CoV-2 than non-IMV patients (33 days, IQR 26-46.75, vs 18 days, IQR 16-46.75, respectively, p < 0.01). Median duration of hospitalisation was 9 days (IQR 6-15.5) for non-IMV and 49.5 days (IQR 36.8-82.5) for IMV patients. Conclusions: Our results indicate a short duration of symptoms before admission as a risk factor for severe disease that merits further investigation and different viral load kinetics in severely affected patients. Median duration of hospitalisation of IMV patients was longer than described for acute respiratory distress syndrome unrelated to COVID-19

Irinotecan and temozolomide in combination with dasatinib and rapamycin versus irinotecan and temozolomide for patients with relapsed or refractory neuroblastoma (RIST-rNB-2011): a multicentre, open-label, randomised, controlled, phase 2 trial

Background Neuroblastoma is the most common extracranial solid tumour in children. Relapsed or refractory neuroblastoma is associated with a poor outcome. We assessed the combination of irinotecan–temozolomide and dasatinib–rapamycin (RIST) in patients with relapsed or refractory neuroblastoma. Methods The multicentre, open-label, randomised, controlled, phase 2, RIST-rNB-2011 trial recruited from 40 paediatric oncology centres in Germany and Austria. Patients aged 1–25 years with high-risk relapsed (defined as recurrence of all stage IV and MYCN amplification stages, after response to treatment) or refractory (progressive disease during primary treatment) neuroblastoma, with Lansky and Karnofsky performance status at least 50%, were assigned (1:1) to RIST (RIST group) or irinotecan–temozolomide (control group) by block randomisation, stratified by MYCN status. We compared RIST (oral rapamycin [loading 3 mg/m2 on day 1, maintenance 1 mg/m2 on days 2–4] and oral dasatinib [2 mg/kg per day] for 4 days with 3 days off, followed by intravenous irinotecan [50 mg/m2 per day] and oral temozolomide [150 mg/m2 per day] for 5 days with 2 days off; one course each of rapamycin–dasatinib and irinotecan–temozolomide for four cycles over 8 weeks, then two courses of rapamycin–dasatinib followed by one course of irinotecan–temozolomide for 12 weeks) with irinotecan–temozolomide alone (with identical dosing as experimental group). The primary endpoint of progression-free survival was analysed in all eligible patients who received at least one course of therapy. The safety population consisted of all patients who received at least one course of therapy and had at least one post-baseline safety assessment. This trial is registered at ClinicalTrials.gov, NCT01467986, and is closed to accrual. Findings Between Aug 26, 2013, and Sept 21, 2020, 129 patients were randomly assigned to the RIST group (n=63) or control group (n=66). Median age was 5·4 years (IQR 3·7–8·1). 124 patients (78 [63%] male and 46 [37%] female) were included in the efficacy analysis. At a median follow-up of 72 months (IQR 31–88), the median progression-free survival was 11 months (95% CI 7–17) in the RIST group and 5 months (2–8) in the control group (hazard ratio 0·62, one-sided 90% CI 0·81; p=0·019). Median progression-free survival in patients with amplified MYCN (n=48) was 6 months (95% CI 4–24) in the RIST group versus 2 months (2–5) in the control group (HR 0·45 [95% CI 0·24-0·84], p=0·012); median progression-free survival in patients without amplified MYCN (n=76) was 14 months (95% CI 9–7) in the RIST group versus 8 months (4–15) in the control group (HR 0·84 [95% CI 0·51–1·38], p=0·49). The most common grade 3 or worse adverse events were neutropenia (54 [81%] of 67 patients given RIST vs 49 [82%] of 60 patients given control), thrombocytopenia (45 [67%] vs 41 [68%]), and anaemia (39 [58%] vs 38 [63%]). Nine serious treatment-related adverse events were reported (five patients given control and four patients given RIST). There were no treatment-related deaths in the control group and one in the RIST group (multiorgan failure). Interpretation RIST-rNB-2011 demonstrated that targeting of MYCN-amplified relapsed or refractory neuroblastoma with a pathway-directed metronomic combination of a multkinase inhibitor and an mTOR inhibitor can improve progression-free survival and overall survival. This exclusive efficacy in MYCN-amplified, relapsed neuroblastoma warrants further investigation in the first-line setting

ChatGPT in Higher Education: The Good, The Bad, and The University

[EN] This research examines the opportunities and risks of artificial intelligence (AI) in the context of higher education, using ChatGPT as an example. The hype around AI tools in education has led to a skeptical attitude among many educators towards this technology. Based on a comprehensive literature analysis, the opportunities and risks of ChatGPT in higher education are identified and analyzed. The research concludes with a recommendation for a sensible use of ChatGPT in higher education. The results of this study can support educators in their decision-making process on whether and how to use ChatGPT as a tool in their teaching contexts.Schönberger, M. (2023). ChatGPT in Higher Education: The Good, The Bad, and The University. Editorial Universitat Politècnica de València. 331-338. https://doi.org/10.4995/HEAd23.2023.1617433133

An AI-based lesson planning software to support competence-based learning

[EN] AbstractTeaching is a complex and cognitively demanding process and a very creative task. A lesson must be carefully prepared to ensure effective, purposeful teaching. Nowadays, lesson plans are also often created using standard software, such as learning or content management systems. It is obvious that this complex process of lesson planning can be supported by specialised software systems that not only facilitate routine tasks but also encourage reflection. This paper explains the idea and concept of a lesson planning software based on artificial intelligence technologies to support competence-based learning. Through the software, teachers should be able to generate individualised learning content easily and intuitively without losing their pedagogical freedoms. Through various user scenarios, the possibilities of the software are demonstrated and explained. Finally, this paper aims to raise awareness of such intelligent learning environments and how they enable an automated development of learning content along the lifelong education chain.The authors would like to express their sincere thanks to the German Federal Ministry of Education and Research (BMBF), which is the funding agency for the project “CLEVER, FKZ: 01PP19001A” underlying this research paper.Pender, H.; Bohl, L.; Schönberger, M.; Knopf, J. (2022). An AI-based lesson planning software to support competence-based learning. En 8th International Conference on Higher Education Advances (HEAd'22). Editorial Universitat Politècnica de València. 1033-1041. https://doi.org/10.4995/HEAd22.2022.145991033104

Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study

Purpose!#!Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical and virological disease trajectories. The purpose of this work was to identify risk factors associated with need for invasive mechanical ventilation (IMV), to analyse viral kinetics in patients with and without IMV and to provide a comprehensive description of clinical course.!##!Methods!#!A cohort of 168 hospitalised adult COVID-19 patients enrolled in a prospective observational study at a large European tertiary care centre was analysed.!##!Results!#!Forty-four per cent (71/161) of patients required invasive mechanical ventilation (IMV). Shorter duration of symptoms before admission (aOR 1.22 per day less, 95% CI 1.10-1.37, p &amp;lt; 0.01) and history of hypertension (aOR 5.55, 95% CI 2.00-16.82, p &amp;lt; 0.01) were associated with need for IMV. Patients on IMV had higher maximal concentrations, slower decline rates, and longer shedding of SARS-CoV-2 than non-IMV patients (33 days, IQR 26-46.75, vs 18 days, IQR 16-46.75, respectively, p &amp;lt; 0.01). Median duration of hospitalisation was 9 days (IQR 6-15.5) for non-IMV and 49.5 days (IQR 36.8-82.5) for IMV patients.!##!Conclusions!#!Our results indicate a short duration of symptoms before admission as a risk factor for severe disease that merits further investigation and different viral load kinetics in severely affected patients. Median duration of hospitalisation of IMV patients was longer than described for acute respiratory distress syndrome unrelated to COVID-19