Integrating Aerial Base Stations for sustainable urban mobile networks

The extensive densification of mobile networks is increasing the network energy consumption and leading to remarkable economical and sustainability concerns. At the same time, regulatory and physical constraints, especially in urban environments, may limit the network expansion and the free installation of Base Stations (BSs). In this context, High Altitude Platform Stations (HAPSs) are emerging as a promising solution to host aerial BSs that can provide additional capacity over a wide geographical area, to offload the on-ground mobile network and support a sustainable transition towards the 6G era. This paper investigates the potential of HAPS offloading to reduce the energy demand from the grid and the operational cost of mobile networks. Our results highlight the effectiveness of HAPS offloading in reducing the size of the RE supply that is required to achieve grid energy reduction on the terrestrial network, thus enhancing the feasibility of a sustainable evolution towards 6G networks. Different allocation strategies are designed and analyzed under several configuration settings, to dynamically adapt the HAPS capacity to the traffic variability in space and over time. A fine tuning of the strategy settings is proved effective in trading off physical constraints, operational cost, sustainability goals, and Quality of Service

A foot in both camps: Redressing the balance between the \u2018pure\u2019 and applied branches of translation studies

The aim of this article is to argue for an approach to translation research integrating/bridging the divide between the descriptive, theoretical and applied branches of Translation Studies (TS). Based on a perspective of translation as cross-cultural communication centred on language and as a professional activity where the translator makes decisions, the branch of Applied Translation Studies (ATS) is seen not just as an \u201cextension\u201d of the \u201cpure\u201d branches of TS (Theory and Description), or one where theoretical statements based on the results of descriptive studies are transmitted in a unidirectional way (Toury 1995: 17-19). Rather, the applied strand of TS covering translation teaching and practice, translation quality assessment, the development of translation aids etc. is effectively incorporated in the disciplinary core of TS, providing a site for testing theoretical statements, identifying problems and providing explanations to be fed into the theory

Jets from Sub-Parsec to Kiloparsec Scales: A Physical Connection

The Chandra discovery of bright X-ray emission from kpc-scale jets allows insight into the physical parameters of the jet flow at large scale. At the opposite extreme, extensive studies of the inner relativistic jets in Blazars with multiwavelength observations, yield comparable information on sub-parsec scales. In the framework of simple radiation models for the emission regions we compare the physical parameters of jets on these two very different scales in the only two well studied Blazars for which large-scale emission has been resolved by Chandra. Notably, we find that the relativistic Doppler factors and powers derived independently at the two scales are consistent, suggesting that the jet does not suffer severe deceleration or dissipation. Moreover the internal equipartition pressures in the inner jet and in the external X-ray bright knots scale inversely with the jet cross section as expected in the simple picture of a freely expanding jet in equipartition.Comment: 4 figures, accepted by Ap

Моделирование энергопотребления зданий: оценка статической и динамической моделей

The aim of the present paper is to show recent results obtained in modeling the building system, presenting a review on the common numerical models used to estimate the energy consumptions. In particular, both steady-state and dynamic models are investigated by analyzing their main assumptions, limitations and fields of usage. As a matter of fact, the most common models are based on steady state approaches, but new technologies and the need to implement innovative regulation criteria for heating and cooling systems by performing detailed coupled studies on the building and heating/cooling systems, push towards the use of dynamic tools with low computational costs. Therefore, the use of dynamic models is often suggested, especially when different building configurations are investigated (as e. g. in the design stage or for a renovation perspective). Starting from this point, sensitive analyses on the installation of a proper insulation in the building envelope is then presented.Цель данной работы — показать последние результаты, полученные при моделировании системы здания, с описанием общих численных моделей, используемых для оценки энергопотребления. В частности на статических и динамических моделях исследованы основные допущения, ограничения и область использования путем их анализа. Собственно говоря, наиболее распространенные модели основаны на установившихся подходах, но новые технологии и необходимость внедрения для систем отопления и холодоснабжения инновационных критериев регулирования с использованием подробного анализа здания и систем отопления/охлаждения, подталкивают к использованию динамических инструментов с низкими вычислительными затратами. Таким образом, часто целесообразно использование динамических моделей, особенно когда существуют разные конфигурации здания (как, например, в стадии проектирования или для перспективной реконструкции). В статье представлен анализ установки правильного утеплителя в ограждающих конструкциях

Technical Solutions and Standards Upgrade for Photovoltaic Systems Operated over 1500 Vdc

This paper deals with photovoltaic (PV) systems with operating voltage increased over the value 1500 V in DC, which represents the limit of the current solutions and the actual standard for the PV plant at utility-scale level. The increase of the DC voltage is aimed at reducing the cable energy losses, the number of components and to optimise the layout of the plants, increasing the competitiveness of Medium Voltage PV (MVPV) solutions with rated powers of hundreds of megawatt. The analysis carried out has identified the possible solutions to adopt in order to reach this target and has remarked that today the International Standards are not covering all the aspects of the technical solutions to be introduced in a MVPV plant. This paper indicates the key issues to be addressed by new Standards on some components in order to enable the deployment of MVPV solutions. Finally, the characteristics of an installation at 1500 V DC and some results of tests carried out on the isolation system of a 1500 V PV plant are discussed

Intestinal parasites of owned dogs and cats from metropolitan and micropolitan areas: prevalence, zoonotic risks, and pet owner awareness in northern Italy

Intestinal parasites of dogs and cats are cosmopolitan pathogens with zoonotic potential for humans. Our investigation considered their diffusion in dogs and cats from northern Italy areas, specifically the metropolitan area of Milan and two micropolitan areas of neighboring provinces. It included the study of the level of awareness in pet owners of the zoonotic potential from these parasites. A total of 409 fresh fecal samples were collected from household dogs and cats for copromicroscopic analysis and detection of Giardia duodenalis coproantigens. The assemblages of Giardia were also identified. A questionnaire about intestinal parasites biology and zoonotic potential was submitted to 185 pet owners. The overall prevalence of intestinal parasites resulted higher in cats (47.37%-60.42%) and dogs (57.41%-43.02%) from micropolitan areas than that from the metropolis of Milan (dogs: P = 28.16%; cats: P = 32.58 %). The zoonotic parasites infecting pets under investigation were T. canis and T. cati, T. vulpis, Ancylostomatidae, and G. duodenalis assemblage A. Only 49.19% of pet owners showed to be aware of the risks for human health from canine and feline intestinal parasites. Parasitological results in pets and awareness determination in their owners clearly highlight how the role of veterinarians is important in indicating correct and widespread behaviors to reduce risks of infection for pets and humans in urban areas

Ultrasound delivery of Surface Enhanced InfraRed Absorption active gold-nanoprobes into fibroblast cells: a biological study via Synchrotron-based InfraRed microanalysis at single cell level

Ultrasound (US) induced transient membrane permeabilisation has emerged as a hugely promising tool for the delivery of exogenous vectors through the cytoplasmic membrane, paving the way to the design of novel anticancer strategies by targeting functional nanomaterials to specific biological sites. An essential step towards this end is the detailed recognition of suitably marked nanoparticles in sonoporated cells and the investigation of the potential related biological effects. By taking advantage of Synchrotron Radiation fourier transform infrared micro-spectroscopy (SR-microftiR) in providing highly sensitive analysis at the single cell level, we studied the internalisation of a nanoprobe within fibroblasts (NIH-3T3) promoted by low-intensity US. To this aim we employed 20 nm gold nanoparticles conjugated with the IR marker 4-aminothiophenol. The significant Surface Enhanced Infrared Absorption provided by the nanoprobes, with an absorbance increase up to two orders of magnitude, allowed us to efficiently recognise their inclusion within cells. Notably, the selective and stable SR- microftiR detection from single cells that have internalised the nanoprobe exhibited clear changes in both shape and intensity of the spectral profile, highlighting the occurrence of biological effects. Flow cytometry, immunofluorescence and murine cytokinesis-block micronucleus assays confirmed the presence of slight but significant cytotoxic and genotoxic events associated with the US-nanoprobe combined treatments. our results can provide novel hints towards US and nanomedicine combined strategies for cell spectral imaging as well as drug delivery-based therapies

Hyperelastic modelling of post-buckling response in single wall carbon nanotubes under axial compression

AbstractThis paper presents a hyperelastic finite element-based lattice approach for the description of post-buckling response in single wall carbon nanotubes (SWCNTs). A one-term incompressible Ogden-type hyperelastic model is adopted to describe the mechanical response of SWCNTs under axial compression. Numerical experiments are carried out and the results are compared to atomistic simulations, demonstrating the predictive capabilities of the present model in capturing post-buckling behaviour and the main deformation mechanisms under large compressive deformations

Open issues in mucopolysaccharidosis type I-hurler

Mucopolysaccharidosis I-Hurler (MPS I-H) is the most severe form of a metabolic genetic disease caused by mutations of IDUA gene encoding the lysosomal α-L-iduronidase enzyme. MPS I-H is a rare, life-threatening disease, evolving in multisystem morbidity including progressive neurological disease, upper airway obstruction, skeletal deformity and cardiomyopathy. Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the gold standard for the treatment of MPS I-H in patients diagnosed and treated before 2-2.5 years of age, having a high rate of success. Beyond the child's age, other factors influence the probability of treatment success, including the selection of patients, of graft source and the donor type employed. Enzyme replacement therapy (ERT) with human recombinant laronidase has also been demonstrated to be effective in ameliorating the clinical conditions of pre-transplant MPS I-H patients and in improving HSCT outcome, by peri-transplant co-administration. Nevertheless the long-term clinical outcome even after successful HSCT varies considerably, with a persisting residual disease burden. Other strategies must then be considered to improve the outcome of these patients: one is to pursue early pre-symptomatic diagnosis through newborn screening and another one is the identification of novel treatments. In this perspective, even though newborn screening can be envisaged as a future attractive perspective, presently the best path to be pursued embraces an improved awareness of signs and symptoms of the disorder by primary care providers and pediatricians, in order for the patients' timely referral to a qualified reference center. Furthermore, sensitive new biochemical markers must be identified to better define the clinical severity of the disease at birth, to support clinical judgement during the follow-up and to compare the effects of the different therapies. A prolonged neuropsychological follow-up of post-transplant cognitive development of children and residual disease burden is needed. In this perspective, the reference center must guarantee a multidisciplinary follow-up with an expert team. Diagnostic and interventional protocols of reference centers should be standardized whenever possible to allow comparison of clinical data and evaluation of results. This review will focus on all these critical issues related to the management of MPS I-H