Short oestrous cycles in sheep during anoestrus involve defects in progesterone biosynthesis and luteal neovascularisation

Anoestrous ewes can be induced to ovulate by the socio-sexual, 'ram effect'. However, in some ewes the induced ovulation is followed by an abnormally short luteal phase causing a so called, "short cycle". The defect responsible for this luteal dysfunction has not been identified. In this experiment we investigated ovarian and uterine factors implicated in male-induced short cycles in anoestrus ewes using a combined endocrine and molecular strategy. Prior to ovulation, we were able to detect a moderate loss of thecal expression of steroid acute regulatory protein (STAR) in ewes that had not received progesterone priming (which prevents short cycles). At and following ovulation we were able to identify significant loss of expression of genes coding key proteins involved in the biosynthesis of progesterone (STAR, CYP11A1, HSD3B) as well as genes coding proteins critical for vascular development during early luteal development (VEGFA, VEGFR2) suggesting dysfunction in at least two pathways critical for normal luteal function. Furthermore, these changes were associated with a significant reduction of progesterone production and luteal weight. Additionally, we cast doubt on the proposed uterine-mediated effect of prostaglandin F2α as a cause of short cycles by demonstrating both the dysregulation of luteal expression of the PGF receptor, which mediates the luteal effects of PGF2α, and by finding no significant changes in the circulating concentrations of PGFM, the principal metabolite of PGF2α in ewes with short cycles. This study is the first of its kind to examine concurrently, the endocrine and molecular events in the follicular and early luteal stages of the short cycle

Foregrounds in the BOOMERANG-LDB data: a preliminary rms analysis

We present a preliminary analysis of the BOOMERanG LDB maps, focused on foregrounds. BOOMERanG detects dust emission at moderately low galactic latitudes ($b > -20^o$) in bands centered at 90, 150, 240, 410 GHz. At higher Galactic latitudes, we use the BOOMERanG data to set conservative upper limits on the level of contamination at 90 and 150 GHz. We find that the mean square signal correlated with the IRAS/DIRBE dust template is less than 3% of the mean square signal due to CMB anisotropy

Mapping the CMB Sky: The BOOMERANG experiment

We describe the BOOMERanG experiment, a stratospheric balloon telescope intended to measure the Cosmic Microwave Background anisotropy at angular scales between a few degrees and ten arcminutes. The experiment has been optimized for a long duration (7 to 14 days) flight circumnavigating Antarctica at the end of 1998. A test flight was performed on Aug.30, 1997 in Texas. The level of performance achieved in the test flight was satisfactory and compatible with the requirements for the long duration flight.Comment: 11 pages, 6 figure

Noise Properties of the BOOMERANG Instrument

In this paper we report a short description of the BOOMERANG experiment explaining his scientific goal and the technologies implied. We concentrate then on the analysis of the noise properties discussing in particular the scan synchronous noise. Finally we present the calibration technique and the sensitivity of all the channels

First Estimations of Cosmological Parameters From BOOMERANG

The anisotropy of the cosmic microwave background radiation contains information about the contents and history of the universe. We report new limits on cosmological parameters derived from the angular power spectrum measured in the first Antarctic flight of the BOOMERANG experiment. Within the framework of inflation-motivated adiabatic cold dark matter models, and using only weakly restrictive prior probabilites on the age of the universe and the Hubble expansion parameter $h$, we find that the curvature is consistent with flat and that the primordial fluctuation spectrum is consistent with scale invariant, in agreement with the basic inflation paradigm. We find that the data prefer a baryon density $\Omega_b h^2$ above, though similar to, the estimates from light element abundances and big bang nucleosynthesis. When combined with large scale structure observations, the BOOMERANG data provide clear detections of both dark matter and dark energy contributions to the total energy density $\Omega_{\rm {tot}}$, independent of data from high redshift supernovae.Comment: As submitted to PRD, revised longer version with an additional figur

The BOOMERANG North America Instrument: a balloon-borne bolometric radiometer optimized for measurements of cosmic background radiation anisotropies from 0.3 to 4 degrees

We describe the BOOMERANG North America (BNA) instrument, a balloon-borne bolometric radiometer designed to map the Cosmic Microwave Background (CMB) radiation with 0.3 deg resolution over a significant portion of the sky. This receiver employs new technologies in bolometers, readout electronics, millimeter-wave optics and filters, cryogenics, scan and attitude reconstruction. All these subsystems are described in detail in this paper. The system has been fully calibrated in flight using a variety of techniques which are described and compared. It has been able to obtain a measurement of the first peak in the CMB angular power spectrum in a single balloon flight, few hours long, and was a prototype of the BOOMERANG Long Duration Balloon (BLDB) experiment.Comment: 40 pages, 22 figures, submitted to Ap

ℓ-space spectroscopy of the Cosmic Microwave Background with the BOOMERanG experiment

The BOOMERanG experiment has recently produced detailed maps of the Cosmic Microwave Background, where sub-horizon structures are resolved with good signal to noise ratio. A power spectrum (spherical harmonics) analysis of the maps detects three peaks, at multipoles ℓ = (213_(-13)^(+10)),(541_(-32)^(+20))(845_(-25)^(+12)). In this paper we discuss the data analysis and the implications of these results for cosmology