New Prebiotic Blend of Polydextrose and Galacto-oligosaccharides Has a Bifidogenic Effect in Young Infants

Objective: The aim of the study was to evaluate the effect of infant formula with polydextrose (PDX) and galacto-oligosaccharides (GOS) on fecal microbiota and secretory IgA (sIgA). Materials and Methods: In the present double-blind, randomized study, term infants received control (Enfamil Lipil) or the same formula with PDX/GOS (4 g/L, 1:1 ratio; PDX/GOS) for 60 days; a reference breast-fed group was included. Formula intake, tolerance, and stool characteristics were collected via electronic diary and analyzed by repeated measures analysis of variance. Anthropometric measurements and stool samples were obtained at baseline and after 30 and 60 days of feeding. Fecal sIgA was measured by enzyme-linked immunosorbent assay and fecal bacteria by fluorescent in situ hybridization and quantitative real-time polymerase chain reaction (qPCR); both were analyzed by Wilcoxon rank sum test. Results: Two hundred thirty infants completed the study. Infants consuming PDX/GOS had softer stools than control at all times (P <0.001). Using qPCR, counts in PDX/GOS were closer to the breast-fed group, tended to be higher than control for total bifidobacteria (P=0.069) and Bifidobacterium longum (P=0.057) at 30 days, and were significantly higher for total bifidobacteria and B longum at 60 days and B infantis at 30 days (P = 0.002). No significant differences were detected between PDX/GOS and control in changes from baseline to 30 or 60 days for sIgA or total bifidobacteria by fluorescent in situ hybridization or qPCR; however, significantly higher changes from baseline were detected between PDX/GOS and control for B infantis at 30 days and B longum at 60 days (P Conclusions: Infant formula with PDX/GOS produces soft stools and a bifidogenic effect closer to breast milk than formula without PDX/GOS

Journal of Pediatric Gastroenterology and Nutrition

Texto completo: acesso restrito. p. 288–290Healthy 9- to 48-month-old children (n = 133) were randomized to receive a cow's-milk–based follow-on formula (control) or the same formula with polydextrose and galactooligosaccharides (PDX/GOS) for 108 days. Pediatricians assessed diarrheal disease, stool pattern, acute respiratory infection, systemic antibiotic use, and growth. The 2 groups had similar weight-for-length/height z score and similar odds of having diarrheal disease, acute respiratory infection, and systemic antibiotic use; however, PDX/GOS had greater odds of increased defecation than control (P <= 0.01). Addition of PDX and GOS to a follow-on formula was well tolerated and induced a pattern of more frequent and softer stools in toddlers

Correction to: International prospective observational cohort study of Zika in infants and pregnancy (ZIP study): study protocol

Submitted by Raphael Belchior ([email protected]) on 2020-04-02T14:11:51Z No. of bitstreams: 1 CRIS-IGM - IAM - IFF - Correction to International prospective observational.pdf: 200493 bytes, checksum: eaf9fa851765899cd56883a5e128bb4e (MD5)Approved for entry into archive by Raphael Belchior ([email protected]) on 2020-04-02T14:14:55Z (GMT) No. of bitstreams: 1 CRIS-IGM - IAM - IFF - Correction to International prospective observational.pdf: 200493 bytes, checksum: eaf9fa851765899cd56883a5e128bb4e (MD5)Made available in DSpace on 2020-04-02T14:14:55Z (GMT). No. of bitstreams: 1 CRIS-IGM - IAM - IFF - Correction to International prospective observational.pdf: 200493 bytes, checksum: eaf9fa851765899cd56883a5e128bb4e (MD5) Previous issue date: 2019Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis.Centro Nacional de Diagnostico y Referencia, Complejo Nacional de Salud, Managua, Nicaragua.Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.Fundação Oswaldo Cruz. Presidência. Centro de Relações Internacionais em Saúde. Rio de Janeiro, RJ, Brasil.Fundación para la Alimentación y Nutrición de Centro América y Panamá (INCAP), Guatemala City, Guatemala.Section of Nutrition, Pediatrics, University of Colorado, Aurora, CO, USA.Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.Section of Nutrition, Pediatrics, University of Colorado, Aurora, CO, USA.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departmento de Virologia e Terapias Experimentais. Recife, PE, Brasil / School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.Director of Research Institute at Imbanaco Medical Center, Cali, Colombia.Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco, Microcephaly Epidemic Research Group, Recife, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Ribeirão Preto Medical School, Ribeirão Preto, Brazil.Instituto de Medicina Tropical Alexander von Humboldt and Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.Department of Pathobiological Sciences, University of Wisconsin, Madison, WI, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, 38105, USA.Department of Epidemiology, Harvard Chan School of Public Health, Boston, MA, USA.Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.Instituto de Medicina Tropical Alexander von Humboldt and Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.University of Puerto Rico, San Juan, Puerto Rico.Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.University of Puerto Rico, San Juan, Puerto Rico.Maternal-Infant Studies Center (CEMI), San Juan, Puerto Rico.Following publication of the original article [1], the author mentioned that two additional NIH staff were involved in the development of the protocol who did not receive recognition in the Acknowledgments section in their published article

International prospective observational cohort study of Zika in infants and pregnancy (ZIP study): study protocol

Submitted by Raphael Belchior ([email protected]) on 2020-04-02T13:47:38Z No. of bitstreams: 1 CRIS-IGM - IAM - IFF - International prospective observational.pdf: 600810 bytes, checksum: 8e0c7389346277503afb09ceb41010da (MD5)Approved for entry into archive by Raphael Belchior ([email protected]) on 2020-04-02T14:05:08Z (GMT) No. of bitstreams: 1 CRIS-IGM - IAM - IFF - International prospective observational.pdf: 600810 bytes, checksum: 8e0c7389346277503afb09ceb41010da (MD5)Made available in DSpace on 2020-04-02T14:05:08Z (GMT). No. of bitstreams: 1 CRIS-IGM - IAM - IFF - International prospective observational.pdf: 600810 bytes, checksum: 8e0c7389346277503afb09ceb41010da (MD5) Previous issue date: 2019Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis.Centro Nacional de Diagnostico y Referencia, Complejo Nacional de Salud, Managua, Nicaragua.Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.Fundação Oswaldo Cruz. Presidência. Centro de Relações Internacionais em Saúde. Rio de Janeiro, RJ, Brasil.Fundación para la Alimentación y Nutrición de Centro América y Panamá (INCAP), Guatemala City, Guatemala.Section of Nutrition, Pediatrics, University of Colorado, Aurora, CO, USA.Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.Section of Nutrition, Pediatrics, University of Colorado, Aurora, CO, USA.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departmento de Virologia e Terapias Experimentais. Recife, PE, Brasil / School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.Director of Research Institute at Imbanaco Medical Center, Cali, Colombia.Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco, Microcephaly Epidemic Research Group, Recife, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Ribeirão Preto Medical School, Ribeirão Preto, Brazil.Instituto de Medicina Tropical Alexander von Humboldt and Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.Department of Pathobiological Sciences, University of Wisconsin, Madison, WI, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, 38105, USA.Department of Epidemiology, Harvard Chan School of Public Health, Boston, MA, USA.Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.Instituto de Medicina Tropical Alexander von Humboldt and Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.University of Puerto Rico, San Juan, Puerto Rico.Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.University of Puerto Rico, San Juan, Puerto Rico.Maternal-Infant Studies Center (CEMI), San Juan, Puerto Rico.Until recently, Zika virus (ZIKV) infections were considered mild and self-limiting. Since 2015, they have been associated with an increase in microcephaly and other birth defects in newborns. While this association has been observed in case reports and epidemiological studies, the nature and extent of the relationship between ZIKV and adverse pregnancy and pediatric health outcomes is not well understood. With the unique opportunity to prospectively explore the full spectrum of issues related to ZIKV exposure during pregnancy, we undertook a multi-country, prospective cohort study to evaluate the association between ZIKV and pregnancy, neonatal, and infant outcomes