Exceptional Response in BRAF p.V600E-Mutant Enteric-Type Adenocarcinoma of the Lung With Cutaneous Spread: A Case Report

Background: Enteric-type adenocarcinoma of the lung (lung-ETAC) is a rare form of lung cancer with histologic similarities to colorectal cancer, with aggressive behavior and unfavorable prognosis. Case presentation: An 81-year-old man presented with discolored skin lesions on the chest and abdomen. After comprehensive evaluation, including skin biopsy and molecular profiling, the patient was diagnosed with having lung-ETAC with a BRAF p.V600E mutation. Treatment with dabrafenib and trametinib initially resulted in positive results, with improvement in skin lesions and overall clinical condition. Nevertheless, approximately 6 months after, the disease had progression with new skin lesions reappearing. Conclusions: We reported a unique case of a patient with BRAF p.V600E-mutant lung-ETAC with metastatic skin lesions achieving complete cutaneous response after targeted treatment with dabrafenib and trametinib, highlighting the potential for targeted therapy in patients with lung-ETAC harboring a BRAF p.V600E mutation

University of California Press eScholarship editions in process

Knights at Court is a grand tour and survey of manners, manhood, and court life in the Middle Ages, like no other in print. Composed on an epic canvas, this authoritative work traces the development of court culture and its various manifestations from the latter years of the Holy Roman Empire (ca. A.D. 1000) to the Italian Renaissance of the fifteenth and sixteenth centuries.Leading medievalist and Renaissance scholar Aldo Scaglione offers a sweeping sociological view of three geographic areas that reveals a surprising continuity of courtly forms and motifs: German romances; the lyrical and narrative literature of northern and southern France; Italy's chivalric poetry. Scaglione discusses a broad number of texts, from early Norman and Flemish baronial chronicles to the romances of Chrétien de Troyes, the troubadours and Minnesingers. He delves into the Niebelungenlied, Dante, Petrarch, Boccaccio, and an array of treatises on conduct down to Castiglione and his successors.All these works and Scaglione's superior scholarship attest to the enduring power over minds and hearts of a mentality that issued from a small minority of people - the courtiers and knights - in central positions of leadership and power. Knights at Court is for all scholars and students interested in "the civilizing process.

A randomized controlled trial investigating the use of a predictive nomogram for the selection of the FSH starting dose in IVF/ICSI cycles

The number of oocytes retrieved is a relevant intermediate outcome in women undergoing IVF/intracytoplasmic sperm injection (ICSI). This trial compared the efficiency of the selection of the FSH starting dose according to a nomogram based on multiple biomarkers (age, day 3 FSH, anti-Müllerian hormone) versus an age-based strategy. The primary outcome measure was the proportion of women with an optimal number of retrieved oocytes defined as 8-14. At their first IVF/ICSI cycle, 191 patients underwent a long gonadotrophin-releasing hormone agonist protocol and were randomized to receive a starting dose of recombinant (human) FSH, based on their age (150 IU if ≤35 years, 225 IU if >35 years) or based on the nomogram. Optimal response was observed in 58/92 patients (63%) in the nomogram group and in 42/99 (42%) in the control group (+21%, 95% CI = 0.07 to 0.35, P = 0.0037). No significant differences were found in the clinical pregnancy rate or the number of embryos cryopreserved per patient. The study showed that the FSH starting dose selected according to ovarian reserve is associated with an increase in the proportion of patients with an optimal response: large trials are recommended to investigate any possible effect on the live-birth rate