Effect of alcohol on the postnatal development of cerebellar cortex in rat II: ultrastructural study

In The present work, it was found that alcohol produced distinct changes in both Purkinje and granule cells during postnatal development. On the fifth day, the apical cones of the Purkinje cells were less developed and the cells showed an occasional somnatic spines but no somatic processes. At 21 days and adult stage these cells including their dendrites showed marked degenerative changes. The nuinber of basket cell axon synapses on Purkinje cell soma was reduced. There was also a reduction in the amount of basket fibers contributing to the pinceau around the intial seginent of the Purkinje cell axons. The granule cells showed a marked change starting from five days old. These cells decreased in size and lost most of the organelles. Their axons and dendrites as well as mossy fibers were also affected. Signs of glial activation and proliferation were present in the from of formation of myelin sheaths around the degenerated fibers

Chaos control and numerical solution of time-varying fractional Newton-Leipnik system using fractional Atangana-Baleanu derivatives

Nonlinear fractional differential equations and chaotic systems can be modeled with variable-order differential operators. We propose a generalized numerical scheme to simulate variable-order fractional differential operators. Fractional calculus' fundamental theorem and Lagrange polynomial interpolation are used. Two methods, Atangana-Baleanu-Caputo and Atangana-Seda derivatives, were used to solve a chaotic Newton-Leipnik system problem with fractional operators. Our scheme examined the existence and uniqueness of the solution. We analyze the model qualitatively using its equivalent integral through an iterative convergence sequence. This novel method is illustrated with numerical examples. Simulated and analytical results agree. We contribute to real-world mathematical applications. Finally, we applied a numerical successive approximation method to solve the fractional model

Correlation between Gingival Redness and Oral Health Related Quality of Life in A Group of Egyptian Children at New Giza University

Introduction: The concept of oral health related quality of life (OHRQoL) is of great significance in the three areas of dental health, in particular the clinical practice of dentistry, research, and education. The reported prevalence of gingivitis in various developed countries is considered high. This rate escalates with the increase in age, especially around puberty. There is evidence that gingivitis is associated with the children’s OHRQoL as there are common risk factors between gingivitis’ of adolescence and their consequent OHRQoL. Aim: This study aims to evaluate the correlation between gingival redness as evaluated by digital photographs and oral health related quality of life as measured by the short form of child perception questionnaire 11-14. Subjects and methods: 91 participants 11-14 years-old Egyptian children from New-Giza University outpatients’ clinic were recruited and OHRQoL was evaluated using the Arabic version of the regression short form (RSF) of Child perception questionnaire 11-14 (CPQ 11-14). Gingival redness was evaluated using analyzed digital photographs using Adobe Photoshop Creative Cloud (CC) 2021 software. Results: The study showed that there was insignificant (P \u3e0.05), weak (r \u3c 0.5), positive (+) correlation between the number of red pixels in digital photographs and oral symptoms domain and functional limitation domain. Conclusion: there was no statistically significant correlation between the gingival redness and the oral health related quality of life

Management of postpartum iron deficiency anemia: review of literature

Anemia is a condition in which either the number of circulating red blood cells or their hemoglobin concentration is decreased. As a result, there is decreased transport of oxygen from the lungs to peripheral tissues. The standard approach to treatment of postpartum iron deficiency anemia is oral iron supplementation, with blood transfusion reserved for more server or symptomatic cases. There are a number of hazards of allogenic blood transfusion including transfusion of the wrong blood, infection, anaphylaxis and lung injury, any of which will be devastating for a young mother. These hazards, together with the national shortage of blood products, mean that transfusion should be viewed as a last resort in otherwise young and healthy women. Currently, there are many iron preparations available containing different types of iron salts, including ferrous sulfate, ferrous fumarate, ferrous ascorbate but common adverse drug reactions found with these preparations are mainly gastrointestinal intolerance like nausea, vomiting, constipation, diarrhoea, abdominal pain, while ferrous bis-glycinate (fully reacted chelated amino acid form of iron) rarely make complication. Two types of intravenous (IV) preparations available are IV iron sucrose and IV ferric carboxymaltose. IV iron sucrose is safe, effective and economical. Reported incidence of adverse reactions with IV iron sucrose is less as compared to older iron preparations (Iron dextran, iron sorbitol), but it requires multiple doses and prolonged infusion time. Intramuscular iron sucrose complex is particularly contraindicated because of poor absorption. It was also stated that when iron dextran is given intravenously up to 30% of patients suffer from adverse effects which include arthritis, fever, urticaria and anaphylaxis

Effect of alcohol on the postnatal development of cerebellar cortex in rat guste 1-histological and morphometric studies.

The effect of ethyl alcohol (10%) on the postnatal development of cerebellar cortex was studied using histological and morphometric methods. The external granular layer was much increased in thickness in alcohol fed rat than those of the control while the molecular and granular layer were reduced. The cells of themolecular layer showed neuronal degeneration and many spaces were present in this layer esp \u3c /strong\u3eecially late postnatal. The Purkinje cells failed to reach their final position up the tenth day and still arranged in more than one row. The degenerative changes appeared at five days and increased with age. The extent of their dendritic tree were reduced but with long spines. The granular layer was delayed in its differentiation from the white mather. Starting from fifth day, the degenerative changes were clearly noticed in the cells and fibers. The mean number of Purkinje and granule cells in alcohol fed rats were reduced in all lobules in all ages. The most affected lobules were lobules II & III in the anteror lobe then lobules IX & X in the posterior lobe. The numerical densities of granule and Purkinje cells per unit volume of tissue were lower than the control. This density was significantly reduced at 5-21 days. The granule -to- Purkinje cell ratios were increased in alcohol fed rats than those of the control. There was a slight decrease in this ratio in the adult stage

The fractal-fractional Atangana-Baleanu operator for pneumonia disease: stability, statistical and numerical analyses

The present paper studies pneumonia transmission dynamics by using fractal-fractional operators in the Atangana-Baleanu sense. Our model predicts pneumonia transmission dynamically. Our goal is to generalize five ODEs of the first order under the assumption of five unknowns (susceptible, vaccinated, carriers, infected, and recovered). The Atangana-Baleanu operator is used in addition to analysing existence, uniqueness, and non-negativity of solutions, local and global stability, Hyers-Ulam stability, and sensitivity analysis. As long as the basic reproduction number $\mathscr{R}_{0}$ is less than one, the free equilibrium point is local, asymptotic, or otherwise global. Our sensitivity statistical analysis shows that $\mathscr{R}_{0}$ is most sensitive to pneumonia disease density. Further, we compute a numerical solution for the model by using fractal-fractional. Graphs of the results are presented for demonstration of our proposed method. The results of the Atangana-Baleanu fractal-fractional scheme is in excellent agreement with the actual data

Evaluations of Ovarian and Luteal Blood Flow Waveform Patterns in Buffalos Subjected to OvSynch Protocol in Cold and Hot Seasons

This current study aimed to determine ovarian and luteal blood flow waveform patterns in buffalos synchronized using OvSynch protocol in cold and hot seasons. Six cyclic buffalo cows aged 6±0.5 years old, having a weight of 400 ± 50 kg, were scanned daily along three successive estrous cycles transrectally by Doppler ultrasonography to evaluate the normal ovarian hemodynamic during the normal spontaneous ovulation and before the start of experiments. Buffaloes were synchronized with gonadotropin[GnRH] –prostaglandin[P] –gonadotropin (GPG) protocol in which animals received 10μg of GnRH on day ??, 0.250μg of PGF2α on day 7, and another dose of 10μg of GnRH was administered 48h after the PGF2α injection. Blood sampling and ovarian ultrasound examinations (color and spectral Doppler modes) were conducted on the day of the estrous and luteal phases. Results revealed that peak systolic velocity waveform (PSV) was significantly (P<0.05) increased in the cold season compared to the hot season. The Luteal blood flow after the end of OvSynch protocol on days (5,7,9, and 11) was significantly increased in the cold season than that in the hot one. The serum levels of estradiol (E2) and nitric oxide (NO) after the second GnRH injection in the OvSynch protocol were significantly (P<0.05) elevated in the cold season as compared to the hot one. Moreover, the progesterone (P4) levels had risen in OvSynch-treated buffaloes on days 5,7,9, and 11 of the cycle in the cold season compared to the hot one. Conclusion: In the cold season, ovarian hemodynamics was significantly improved compared to the hot one; this may influence the reproductive efficiency of buffaloes. Further studies were needed to prove it

Analgesic Effect of Intra-Articular Dexamethasone versus Fentanyl added as an adjuvant to Bupivacaine for Postoperative Pain Relief in Knee Arthroscopic Surgery

Background: Knee arthroscopy is usually associated with a variable degree of pain ranging from moderate-to-severe pain in about 70% of patients. Objective: This trial was designed to assess the efficacy of intra-articular administration of dexamethasone versus fentanyl as adjuncts to bupivacaine in patients undergoing arthroscopic knee surgery. Patients and methods: Eighty-nine patients of either sex were enrolled in this study. The patients were randomly divided into three equal groups. Group F that received intra-articular (IA) injection of 1 μg/kg fentanyl (In 2 ml saline) added to 18 ml of 0.25% bupivacaine, group D, which received IA injection of 8 mg (2 ml) dexamethasone added to 18mL of 0.25% bupivacaine and group S that received IA injection of 2 ml normal saline added to 18 mL of 0.25% bupivacaine. Results: The time required for the first request of analgesia in group F, group D, and group S was 5.7 ± 0.7 vs 4.5 ± 0.5 vs 3.3 ± 0.5 hours respectively. There were significant differences between both treatment groups and the control group (p < 0.001) and in between both treatment groups (p < 0.001) in favor of group F. There was a significantly lower median visual analogue score in group F when compared to group D and S at 6 hours (p = 0.006 & 0.01, respectively), 12 hours (p < 0.001 & < 0.001, respectively), and 18 hours (p = 0.003 & 0.007, respectively) postoperatively. Conclusion: The addition of fentanyl or dexamethasone to IA bupivacaine in knee arthroscopic surgery provided a better quality of analgesia with less consumption of systemic analgesics without significant adverse effects

Intraoperative internal iliac artery balloon occlusion versus ligation in cases of placenta previa accreta: A randomized trial

ABSTRACT Aims: The aim of the study was to compare the efficacy of intraoperative bilateral internal iliac artery balloon occlusion versus bilateral internal iliac artery ligation before extraction of placenta previa accreta after fetal delivery. Methods: One hundred patients with preoperative diagnosis of placenta previa accreta were randomly allocated into two groups each including 50 patients; Group (A) intraoperative internal iliac artery (IIA) balloon occlusion was undergone and Group (B) internal iliac artery ligation was undergone

A practical approach for outdoors distributed target localization in wireless sensor networks

Wireless sensor networks are posed as the new communication paradigm where the use of small, low-complexity, and low-power devices is preferred over costly centralized systems. The spectra of potential applications of sensor networks is very wide, ranging from monitoring, surveillance, and localization, among others. Localization is a key application in sensor networks and the use of simple, efficient, and distributed algorithms is of paramount practical importance. Combining convex optimization tools with consensus algorithms we propose a distributed localization algorithm for scenarios where received signal strength indicator readings are used. We approach the localization problem by formulating an alternative problem that uses distance estimates locally computed at each node. The formulated problem is solved by a relaxed version using semidefinite relaxation technique. Conditions under which the relaxed problem yields to the same solution as the original problem are given and a distributed consensusbased implementation of the algorithm is proposed based on an augmented Lagrangian approach and primaldual decomposition methods. Although suboptimal, the proposed approach is very suitable for its implementation in real sensor networks, i.e., it is scalable, robust against node failures and requires only local communication among neighboring nodes. Simulation results show that running an additional local search around the found solution can yield performance close to the maximum likelihood estimate