1,883 research outputs found
Recommended from our members
Continuity in the neural system supporting children's theory of mind development: Longitudinal links between task-independent EEG and task-dependent fMRI.
Children's explicit theory of mind (ToM) understandings change over early childhood. We examined whether there is longitudinal stability in the neurobiological bases of ToM across this time period. A previous study found that source-localized resting EEG alpha attributable to the dorsal medial prefrontal cortex (DMPFC) and right temporoparietal junction (RTPJ) was associated with children's performance on a battery of theory of mind tasks. Here, we investigated a small subset of children (Nâ=â12) in that original study as a preliminary investigation of whether behavioral measures of ToM performance, and/or EEG localized to the DMPFC or RTPJ predicted ToM-specific fMRI responses 3.5 years later. Results showed that preschoolers' behavioral ToM-performance positively predicted later ToM-specific fMRI responses in the DMPFC. Preschoolers' resting EEG attributable to the DMPFC also predicted later ToM-specific fMRI responses in the DMPFC. Given the small sample, results represent a first exploration and require replication. Intriguingly, they suggest that early maturation of the area of the DMPFC related to ToM reasoning is positively linked with its specific recruitment for ToM reasoning later in development, affording implications for characterizing conceptual ToM development, and its underlying neural supports
Continual Learning in the Teacher-Student Setup: Impact of Task Similarity
Continual learningâthe ability to learn many tasks in sequenceâis critical for artificial learning systems. Yet standard training methods for deep networks often suffer from catastrophic forgetting, where learning new tasks erases knowledge of the earlier tasks. While catastrophic forgetting labels the problem, the theoretical reasons for interference between tasks remain unclear. Here, we attempt to narrow this gap between theory and practice by studying continual learning in the teacher-student setup. We extend previous analytical work on two-layer networks in the teacher-student setup to multiple teachers. Using each teacher to represent a different task, we investigate how the relationship between teachers affects the amount of forgetting and transfer exhibited by the student when the task switches. In line with recent work, we find that when tasks depend on similar features, intermediate task similarity leads to greatest forgetting. However, feature similarity is only one way in which tasks may be related. The teacher-student approach allows us to disentangle task similarity at the level of \textbackslashemphreadouts (hidden-to-output weights) as well as \textbackslashemphfeatures (input-to-hidden weights). We find a complex interplay between both types of similarity, initial transfer/forgetting rates, maximum transfer/forgetting, and the long-time (post-switch) amount of transfer/forgetting. Together, these results help illuminate the diverse factors contributing to catastrophic forgetting
Mentalizing under Uncertainty: Dissociated Neural Responses to Ambiguous and Unambiguous Mental State Inferences
The ability to read the minds of others (i.e., to mentalize) requires that perceivers understand a wide range of different kinds of mental states, including not only othersâ beliefs and knowledge but also their feelings, desires, and preferences. Moreover, although such inferences may occasionally rely on observable features of a situation, perceivers more typically mentalize under conditions of âuncertainty,â in which they must generate plausible hypotheses about a target's mental state from ambiguous or otherwise underspecified information. Here, we use functional neuroimaging to dissociate the neural bases of these 2 distinct socialâcognitive challenges: 1) mentalizing about different types of mental states (beliefs vs. preferences) and 2) mentalizing under conditions of varying ambiguity. Although these 2 aspects of mentalizing have typically been confounded in earlier research, we observed a double dissociation between the brain regions sensitive to type of mental state and ambiguity. Whereas ventral and dorsal aspects of medial prefrontal cortex responded more during ambiguous than unambiguous inferences regardless of the type of mental state, the right temporoparietal junction was sensitive to the distinction between beliefs and preferences irrespective of certainty. These results underscore the emerging consensus that, rather than comprising a single mental operation, social cognition makes flexible use of different processes as a function of the particular demands of the social context
Developing a truck rollover risk calculator for south africa
The Static Rollover Threshold (SRT) is an important metric for characterising a heavy
vehicleâs inherent stability and risk of rollover. Current methods of assessing SRT include
a tilt-table test and multi-body dynamics simulation which can be costly, time-consuming
and often require significant technical expertise or technical vehicle data not normally
accessible to the public. Simplified calculation methods exist, but a remaining challenge
exists to reduce the required level of user expertise and input data to make the
assessment useable by, for example, fleet insurers who would have an interest in SRT
information. In this paper we investigate the use of simplified calculations prescribed by
the New Zealand Land Transport Rule (NZLTR) and UNECE 111 as the basis for the
development of a user-friendly SRT calculator. The calculation results were validated
against a multi-body dynamics model using TruckSIM for the case of a rigid truck for a
range of vehicle suspension and mass properties. The NZLTR and âinterpolatedâ UNECE
111 methods resulted in the smallest errors compared with TruckSIM, averaging 6-7% in
absolute error over the 16 scenarios assessed. Maximum errors occurred when the ratio
between drive axle and steer axle roll stiffness was at its highest (at a ratio of 4.7:1). The
UNECE 111 method was then used as the basis for a Python-based SRT calculator tool.
The tool demonstrates how pre-loaded technical vehicle data and logic can be used to
minimise the required user expertise and hence make SRT calculation feasible by nontechnical users in the fleet insurance industry in South Africa.Papers presented at the 40th International Southern African Transport Conference on 04 -08 July 202
Mind the Gap: Investigating Toddlersâ Sensitivity to Contact Relations in Predictive Events
Toddlers readily learn predictive relations between events (e.g., that event A predicts event B). However, they intervene on A to try to cause B only in a few contexts: When a dispositional agent initiates the event or when the event is described with causal language. The current studies look at whether toddlersâ failures are due merely to the difficulty of initiating interventions or to more general constraints on the kinds of events they represent as causal. Toddlers saw a block slide towards a base, but an occluder prevented them from seeing whether the block contacted the base; after the block disappeared behind the occluder, a toy connected to the base did or did not activate. We hypothesized that if toddlers construed the events as causal, they would be sensitive to the contact relations between the participants in the predictive event. In Experiment 1, the block either moved spontaneously (no dispositional agent) or emerged already in motion (a dispositional agent was potentially present). Toddlers were sensitive to the contact relations only when a dispositional agent was potentially present. Experiment 2 confirmed that toddlers inferred a hidden agent was present when the block emerged in motion. In Experiment 3, the block moved spontaneously, but the events were described either with non-causal (âhereâs my blockâ) or causal (âthe block can make it goâ) language. Toddlers were sensitive to the contact relations only when given causal language. These findings suggest that dispositional agency and causal language facilitate toddlersâ ability to represent causal relationships.John Templeton Foundation (#12667)James S. McDonnell Foundation (Causal Learning Collaborative Initiative)National Science Foundation (U.S.) (Career Award (# 0744213
The WASp-like protein Scar regulates macropinocytosis, phagocytosis and endosomal membrane flow in Dictyostelium
Scar, a member of the WASp protein family, was discovered in Dictyostelium discoideum during a genetic screen for second-site mutations that suppressed a developmental defect. Disruption of the scar gene reduced the levels of cellular F-actin by 50%. To investigate the role of Scar in endocytosis, phagocytosis and endocytic membrane trafficking, processes that depend on actin polymerization, we have analyzed a Dictyostelium cell line that is genetically null for Scar. Rates of fluid phase macropinocytosis and phagocytosis are significantly reduced in the scar- cell-line. In addition, exocytosis of fluid phase is delayed in these cells and movement of fluid phase from lysosomes to post-lysosomes is also delayed. Inhibition of actin polymerization with cytochalasin A resulted in similar phenotypes, suggesting that Scar-mediated polymerization of the actin cytoskeleton was important in the regulation of these processes. Supporting this conclusion, fluorescence microscopy revealed that some endo-lysosomes were ringed with F-actin in control cells but no F-actin was detected associated with endo-lysosomes in Scar null cells. Disruption of the two genes encoding the actin monomer sequestering protein profilin in wild-type cells causes defects in the rate of pinocytosis and fluid phase efflux. Consistent with a predicted physical interaction between Scar and profilin, disrupting the scar gene in the profilin null background results in greater decreases in the rate of fluid phase internalization and fluid phase release compared to either mutant alone. Taken together, these data support a model in which Scar and profilin functionally interact to regulate internalization of fluid and particles and later steps in the endosomal pathway, probably through regulation of actin cytoskeleton polymerization
- âŠ