Particle production in proton-proton collisions

Proton-proton collision is a simple system to investigate nuclear matter and it is considered to be a guide for more sophisticated processes in the proton-nucleus and the nucleus-nucleus collisions. In this article, we present a phenomological study of how the mechanism of particle production in pp interaction changes over a wide range of interaction energy. This study is done on data of charged particle produced in pp experiments at different values of energy. Some of these data give the created particles classified as hadrons, baryons and mesons, which help us compare between production of different particles. This might probe some changes in the state of nuclear matter and identify the mechanism of interaction.Comment: arXiv admin note: text overlap with arXiv:1410.715

Early administration of oral oseltamivir increases the benefits of influenza treatment

Our objective was to evaluate the benefit of early treatment of influenza illness using oral oseltamivir. This open-label, multicentre international study investigated the relationship between the interval from illness onset to first dose (time-to-treatment) and illness duration in the intent-to-treat infected population using accelerated failure time (AFT) modelling. A total of 1426 patients (12-70 years) presenting within 48 h of the onset of influenza symptoms were treated with oseltamivir 75 mg twice a day for 5 days during the 1999-2000 influenza season; 958 (67%) had laboratory-confirmed influenza virus infection. Earlier intervention was associated with shorter illness duration (P < 0.0001). Initiation of therapy within the first 12 h after fever onset reduced the total median illness duration by 74.6 h (3.1 days; 41%) more than intervention at 48 h. Intermediate interventions reduced the illness proportionately compared with 48 h. In addition, the earlier administration of oseltamivir further reduced the duration of fever, severity of symptoms and the times to return to baseline activity and health scores. Oseltamivir was well tolerated. The most common adverse events were nausea and vomiting, which were transient and generally occurred only with first dosing. When oseltamivir was taken with food, the tolerability was enhanced. The overall discontinuation rate was low (1.8%). In conclusion, the IMPACT study demonstrated that earlier initiation of oral oseltamivir therapy increased its therapeutic effects, which were seen at every time point of intervention and were progressive. Thus, early presentation, diagnosis and treatment of patients with influenza maximized the benefits of oseltamivir therap

Uses of quinazolin-2-[(β-propionoyl)isothiocyanate]-4-one as a building block in synthesis of some heterocyclic compounds of expected biological activity

1153-115

Characteristics of the Early Immune Response Following Transplantation of Mouse ES Cell Derived Insulin-Producing Cell Clusters

Background The fully differentiated progeny of ES cells (ESC) may eventually be used for cell replacement therapy (CRT). However, elements of the innate immune system may contribute to damage or destruction of these tissues when transplanted. Methodology/Principal Findings Herein, we assessed the hitherto ill-defined contribution of the early innate immune response in CRT after transplantation of either ESC derived insulin producing cell clusters (IPCCs) or adult pancreatic islets. Ingress of neutrophil or macrophage cells was noted immediately at the site of IPCC transplantation, but this infiltration was attenuated by day three. Gene profiling identified specific inflammatory cytokines and chemokines that were either absent or sharply reduced by three days after IPCC transplantation. Thus, IPCC transplantation provoked less of an early immune response than pancreatic islet transplantation. Conclusions/Significance Our study offers insights into the characteristics of the immune response of an ESC derived tissue in the incipient stages following transplantation and suggests potential strategies to inhibit cell damage to ensure their long-term perpetuation and functionality in CRT

Interweaving temporal qualitative comparative analysis with necessary conditions analysis: an empirical application in the european monitoring systems context

There are very few empirical applications of Temporal Qualitative Comparative Analysis (TQCA). By interweaving TQCA with the necessary condition analysis stepwise procedure, I endeavour to compare instances of cheating and non-cheating practices within the European Social Fund context and unravel the multiple sequences of events leading to the outcome of interest. Implications for theory and practice are discussed by shedding a new light on the non-trivially necessary causes for both cheating and non-cheating activities