Detonation modeling with the Particles on Demand method

A kinetic model based on the Particles on Demand method is introduced for gas phase detonation hydrodynamics in conjunction with the Lee--Tarver reaction model. The proposed model is realized on two- and three-dimensional lattices and is validated with a set of benchmarks. Quantitative validation is performed with the Chapman--Jouguet theory up to a detonation wave speed of Mach 20 in one dimension. Two-dimensional outward expanding circular detonation is tested for isotropy of the model as well as for the asymptotic detonation wave speed. Mach reflection angles are verified in setups consisting of interacting strong bow shocks emanating from detonation. Spherical detonation is computed to show viability of the proposed model for three dimensional simulations.Comment: Submitted to Physics of Fluids. 11 pages, 10 figure

TO DEVELOP HPLC METHOD FOR THE ASSAY OF MEMANTINE HYDROCHLORIDE TABLETS USING REFRACTIVE INDEX (RI) DETECTOR

Objective: To develop and validate a chromatographic method to determine the amount of drug (assay) in the tablets of memantine hydrochloride (MEM) using high performance liquid chromatography with refractive index (RI) detector. Methods: The chromatographic separation was achieved on C18 (250 × 4.5 mm, 5μ) column using isocratic mobile phase comprises of buffer (pH-6.0): Methanol (45:55 v/v) pumped at a flow rate of 1.0 ml/min. The detection of effluent was monitored using RI detector. Conclusion: The method was found to be simple, commercial, precise, accurate and robust which can be utilized for the determination of assay of MEM in tablets and capsules. Keywords: Memantine hydrochloride, Assay, Liquid chromatography, Refractive Index detecto

A case report: incidental diagnosis of endometrial tuberculosis in cases of abnormal uterine bleeding

Abnormal uterine bleeding (AUB), including heavy menstrual bleeding (HMB), levy a massive burden on society. Here, we discuss about two patients who came to OPD with AUB symptoms for evaluation, but incidentally diagnosed with endometrial tuberculosis. In Case 1, 45-year-old female came with complains of heavy menstrual bleeding for 6 months for 6 months. USG showed adenomyosis. Patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. But on day 7 she developed serous blood-tinged discharge per vaginum. Incidentally, patient endometrial CBNAAT report came positive for MTB, with no resistance to rifampicin. Patient was started on anti-tubercular treatment for 6 months. In Case 2, 43-year-old female came with complaints of HMB with pain abdomen and irregular menses for 3 years. USG shows early changes of Adenomyosis. Patient underwent therapeutic curettage with MIRENA insertion. Endometrial CBNAAT was negative and liquid culture (LJ) was MDR positive. Sensitivity report s/o of isoniazid and rifampicin resistant. Patient was advised monthly close follow up as symptoms were under control. When a routine screening for FGTB by CBNAAT is done for cases of AUB, there are high chances of reporting more cases in a developing nation like India. Hence sending endometrial samples for TB screening in AUB cases can be useful in finding out more cases of genital TB, where their symptoms can be related to TB infection rather than searching for a structural cause that may be is not the cause for the severe symptoms. Due to which mismanagement or unnecessary surgical interventions can be avoided

Proper qq-caterpillars are distinguished by their Chromatic Symmetric Functions

Stanley's Tree Isomorphism Conjecture posits that the chromatic symmetric function can distinguish non-isomorphic trees. While already established for caterpillars and other subclasses of trees, we prove the conjecture's validity for a new class of trees that generalize proper caterpillars, thus confirming the conjecture for a broader class of trees.Comment: 11 page

DISSOLUTION METHOD DEVELOPMENT WITH CHROMATOGRAPHIC METHOD FOR DETERMINATION OF DRUG RELEASE IN DISSOLUTION SAMPLES OF URSODEOXYCHOLIC ACID TABLETS.

Ursodeoxycholic Acid is used in the treatment of Liver disease. An accurate and robust invitro method is developed and validated for measurement of drug release in Ursodeoxycholic Acid tablets. HPLC method for quantification of drug in dissolution samples of Ursodeoxycholic Acid tablet is developed and validated. Phosphate buffer (0.05M) of pH- 7.5 is used as dissolution medium and paddle (USP-II) as apparatus at 75 rpm. The sample was withdrawn after 60 minutes. The developed HPLC method was used for quantitative estimation of drug release in dissolution samples of Ursodeoxycholic Acid tablet. The HPLC column of Hypersil - C18, 250X4.6 mm, 5µm is used. The phosphate buffer of pH – 6.5 and acetonitrile was mixed in the ratio of 50:50v/v pumped at a flow rate of 1.0 ml/minute. The detection was made at wavelength of 210 nm. Through method validation, it is proved that the method is accurate, rugged, precise and robust. The method is linear over the concentration range of 50% – 150%. The method also found very precise.  Mean recovery of Ursodeoxycholic Acid was found 99.6 ±38%. Keywords: Ursodeoxycholic Acid, Dissolution, chromatography, Method Validation

VIBRATIONAL ANALYSIS OF QUARTER CAR VEHICLE DYNAMIC SYSTEM SUBJECTED TO HARMONIC EXCITATION BY ROAD SURFACE

A front suspension of Hyundai Elantra 1992 model is assigned as quarter car model and is considered for the performance study. Modeling the dynamic performance of an automobile car system represents a complex task and forms an important step in its design procedure. In this paper the stationary response of quarter car vehicle model moving with a constant velocity over a rough road is considered for the performance study. For this a simplified model and experimental set up is developed. The deterministic impulses due to road profile are given by an eccentric cam which gives input motion to front suspension acting as a follower of the cam. The displacements obtained by FFT analyzer at upper mount of shock absorber were compared with the analytical and MATLAB results

Study on biology of Thryssa dussumieri (Valenciennes, 1848) from the coast of Ratnagiri, Maharashtra, India

The Dussumier’s thryssa, Thryssa dussumieri is one of the important component of by-catch of trawl and mini purse seine landings at Ratnagiri. The length-weight relationship indicated the isometric growth in T. dussumieri with generalized equation W = 0.0066 L 3.1077. The month-wise relative condition factor showed two peaks coinciding with peak spawning season. All morphometric lengths showed varying degree of correlation with total length. The qualitative and quantitative analysis of food revealed Thryssa dussumieri to be a carnivore, feeding mainly on mysids, copepods, diatoms and juvenile shrimps.The highest GSI value, for females, was observed during March, October, December and January. The male:female ratio was found to be 1:1.4. T. dussumieri has got a prolonged spawning season extending from September to April. The absolute fecundity ranged from 3367 to 14130 eggs with an average of 7420 eggs. Length at sexual maturity has been estimated to be 12.8 cm

Studies on germination and seedling vigour characters for genotype selection in nutmeg (Myristica fragrans Houtt.)

An experiment was conducted at Ratnagiri (Maharashtra) to study the regeneration ability and variability of 34 nutmeg (Myristica fragrans) seedling genotypes. The variations recorded for germination percentage, period required for germination and seedling growth parameters were significant. Higher magnitudes of genotypic coefficient of variation, phenotypic coefficient of variation, heritability and genetic advance on per cent mean basis were recorded for fresh seed weight, germination percentage, days for germination and root length. The selection of nutmeg genotypes at seedling stage on the basis of vigour of the characters such as number, length and breadth of leaves, collar thickness and petiole length would help to identify genotypes for propagation. Among the genotypes studied, N22, N24, N26, N29, N34, N37, N38, N42, N43, N51, N63 and N72 were promising. &nbsp