The research of the maximum wind speed in Tomsk and calculations of dynamic load on antenna systems

The work is concerned with calculations and analysis of the maximum wind speed in Tomsk city. The data for analysis were taken from the TOR-station located in the north-eastern part of the city. The TOR-station sensors to measure a speed and a direction of wind are installed on the 10-meter meteorological mast. Wind is measured by M-63, which uses the standard approach and the program with one-minute averaging for wind gusts recording as well. According to the measured results in the research performed, the estimation of the dynamic and wind load on different types of antenna systems was performed. The work shows the calculations of wind load on ten types of antenna systems, distinguished by their different constructions and antenna areas. For implementation of calculations, we used methods developed in the Central Research and Development Institute of Building Constructions named after V.A. Kucherenko. The research results could be used for design engineering of the static antenna systems and mobile tracking systems for the distant objects

Mapping of the immunodominant regions of the NAD-dependent formate dehydrogenase

AbstractA panel of 4 monoclonal antibodies and 7 polyclonal antisera against NAD-dependent formate dehydrogenase from methylotrophic bacterium Pseudomonas sp. 101 has been obtained. The reactivity of the 37 overlapping proteolytic peptides with the monoclonal antibodies and polyclonal antisera has been studied with ELISA test. The data obtained were interpreted residing on the structural model of the formate dehydrogenase at 3 Å resolution. The immunodominant regions in the formate dehydrogenase molecule and the epitopes for the monoclonal antibodies were elucidated

Modern approaches and diagnostic tools in neurosurgical practice: a case of patient with intracranial hypotension and secondary cervical spine degeneration

We report a case of a 47-years old woman presented to our department with the diagnosis of Chiari I malformation and extensive hydrosyringomyelia. Her main complains were severe headache and chronic pain syndrome in the left side of her breast and left arm. Magnetic resonance imaging (MRI) showed alterations suggestive of the presence of intracranial hypotension (IH), that was confirmed by measurement of cerebrospinal fluid (CSF) opening pressure and then CSF venous fistula was detected by computed tomography myelography (CTM). She was successfully surgically treated which leaded to the regression of the clinical symptoms and radiological alterations. Nevertheless, during her recovery after surgery she had an episode of recurrent left arm pain, which was interpreted as secondary cervical spine degeneration consequence. MRI confirmed C5-C6 disc herniation and transforaminal epidural injection of local anesthetic and corticosteroid solutions was performed. A week later she already felt significant improvement as her pain syndrome regressed a lot. IH should be considered in the differential diagnosis of headache and sagging brainstem and tonsils with cord syrinx on MRI and should not be misinterpreted as Chiari malformation. At the same time, transforaminal epidural injection appears to be an effective tool in modern neurosurgical practice allowing to determine the reason and accurate radiculopathy level

ЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ПРИМЕНЕНИЯ ГИДРОКСИЭТИЛКРАХМАЛОВ ПРИ ТЕРАПИИ ОЖОГОВОГО ШОКА

The retrospective cohort comparative study was conducted in order to evaluate efficiency and safety of using 6% hydroxyethyl starch (HES) 130/0.4 for managing burn shock. The enrollment criteria were as follows: men and women above 18 years old, thermal burns from 20 to 80% of the body surface, the need of infusion therapy, expected duration of the patient’s stay in the intensive care department for more than 3 days, the absence of acute renal failure at the moment of hospital admission. All patients were divided into two groups. The 1st group (HES+) included 24 patients who received infusion therapy for 3 days with Ringer’s solution and 6% HES 130/0.4 additionally, the 2nd group (HES-) included 25 patients who were treated only with Ringer’s solution. Hospital mortality in the group (HES+) made 45.8% (11 patients died), and in the group (HES-) it made 28.0% (7 patients died), p = 0.3182. The extended surface of lesion was the independent factor of acute renal failure development in those suffering from severe burn injury: OR = 1.09 (1.01–1.19), p = 0.04; Baux OR greater index = 1.09 (1.01–1.19), p = 0.02 and the need in catecholamines – OR = 12.7 (1.2–144.9), p = 0.04. The study showed no confident difference in the frequency of acute renal failure, in the need of substitution renal therapy and mortality in two groups of patients receiving and not receiving HES. Using HES solutions in doses not exceeding the recommended ones did not facilitated the reduction of infusion therapy volume. С целью оценки эффективности и безопасности применения 6% раствора гидроксиэтилкрахмала (ГЭК) 130/0.4 для терапии ожогового шока проведено ретроспективное, когортное, сравнительное исследование. Критериями включения являлись: мужчины и женщины в возрасте старше 18 лет, термический ожог на площади от 20 до 80% поверхности тела, необходимость в инфузионной терапии, предполагаемый срок нахождения пациента в отделении реанимации и интенсивной терапии более 3 сут, отсутствие острого почечного повреждения (ОПП) на момент поступления. Все пациенты были разделены на две группы. В 1-ю группу, ГЭК(+), включены 24 пациента, которые в составе инфузионной терапии в первые 3 сут, помимо базового раствора Рингера, получили 6% раствор ГЭК 130/0.4, 2-ю группу, ГЭК(-), составили 25 пациентов, получившие только раствор Рингера. Госпитальная летальность в группе ГЭК(+) – 45,8% (умерли 11 пациентов), а в группе ГЭК(-) – 28,0% (умерли 7 пациентов), p = 0,3182. Независимыми факторами риска развития ОПП у пациентов с ожоговой травмой явились большая площадь поражения: ОШ = 1,09 (1,01–1,19), p = 0,04; больший индекс Baux ОШ = 1,09 (1,01–1,19), p = 0,02 и потребность в катехоламинах – ОШ = 12,7 (1,2–144,9), p = 0,04. В исследовании не обнаружено достоверной разницы в частоте ОПП, потребности в заместительной почечной терапии и смертности в группах пациентов, получавших и не получавших ГЭК. Применение растворов ГЭК в дозах, не превышающих рекомендуемые, не способствовало сокращению объемов инфузионной терапии.

Efficacy increase of silvicultural measures with biological methods in the pine stands

Based on the analysis of database of the pine stands of Belarus affected by annosum root rot, and the results of longstanding research the substantiati on of silvicultural criteria for designation of stump treatment with biological preparations in the pine fore sts to limit the severity of the pathogen is given. It is proposed to differ site selection for stump treatment according to the regional-typological principle because of significant differences in the relative infestation of pine stands in different forest conditions. It was found that that the treatment should be carried out in pine stands of mossy and bracken series of forest types I–III age classes, and in the pine forest s of Gomel and Mogilev region also in age class IV, as well as heather, lichen and cranberry series of fore st types. In this case, the use of biological agents on the basis of the fungus Phlebiopsis gigantea is useful when conducting selective and complete sanitary felling (regardless of intensity), as well as thi nning and cleaning litter (with a sample of at least 20% of a physiologically live pine wood is cut down from the stock) at steady daily average tempera-tures of at least +5°C

EFFICIENCY AND SAFETY OF USING HYDROXYETHYL STARCH IN THE BURN SHOCK MANAGEMENT

The retrospective cohort comparative study was conducted in order to evaluate efficiency and safety of using 6% hydroxyethyl starch (HES) 130/0.4 for managing burn shock. The enrollment criteria were as follows: men and women above 18 years old, thermal burns from 20 to 80% of the body surface, the need of infusion therapy, expected duration of the patient’s stay in the intensive care department for more than 3 days, the absence of acute renal failure at the moment of hospital admission. All patients were divided into two groups. The 1st group (HES+) included 24 patients who received infusion therapy for 3 days with Ringer’s solution and 6% HES 130/0.4 additionally, the 2nd group (HES-) included 25 patients who were treated only with Ringer’s solution. Hospital mortality in the group (HES+) made 45.8% (11 patients died), and in the group (HES-) it made 28.0% (7 patients died), p = 0.3182. The extended surface of lesion was the independent factor of acute renal failure development in those suffering from severe burn injury: OR = 1.09 (1.01–1.19), p = 0.04; Baux OR greater index = 1.09 (1.01–1.19), p = 0.02 and the need in catecholamines – OR = 12.7 (1.2–144.9), p = 0.04. The study showed no confident difference in the frequency of acute renal failure, in the need of substitution renal therapy and mortality in two groups of patients receiving and not receiving HES. Using HES solutions in doses not exceeding the recommended ones did not facilitated the reduction of infusion therapy volume

Diffusion-driven device for a high-resolution dose-response profiling of combination chemotherapy.

Contains fulltext : 80500.pdf (publisher's version ) (Open Access)Combination therapies have proven vital in the fight against HIV and cancer. However, the identification and optimization of such combination therapies is largely experience driven and an activity of clinicians rather than of systematic screening efforts. Here we present a diffusion device, compatible with the format of a 12-well microtiter plate, to create and test all possible mixtures of two substances with only two pipetting steps. Applications to the testing of different drug combinations and the parallel screening of different leukemia cell lines as well as primary patient cells are presented. The diffusion device yields qualitatively and quantitatively comparable results to an MTT viability assay conducted in a standard 96-well format albeit with a tremendous reduction of processing steps. In addition, a fluorescence-based annexin V binding assay of cell death was implemented. Next to the reduction of processing steps, the diffusion device constitutes a considerable assay miniaturization that overcomes the problems typically associated with miniaturization as a consequence of small sample volumes. Given its ease of handling, the device will greatly advance the development and optimization of combination drugs and the identification of optimum drug combinations in personalized medicine