A Case with Anti TNF- α Induced Bullous Pemhigoid

Bruneau de Miré Ph. Coléoptères Carabiques endémiques ou d'origine tropicale de la région du Sous (Maroc méridional). In: Bulletin de la Société entomologique de France, volume 57 (9), novembre 1952. pp. 130-133

Reeducation of hemiplegic shoulder by using EMG biofeedback

WOS: 000437950900024Purpose: The aim of our study was to evaluate the effect of EMG biofeedback on hemiplegic shoulder reeducation. Materials and Methods: A total of 30 patients were included in the study. 10 sessions of EMG biofeedback training was given to the upper trapezius muscle on the affected side of the patients during shoulder movements to provide relaxation. Patients were evaluated before and after treatment; the myoelectric activity and tone of the upper trapezius muscle, and only the tone of the deltoideus muscle. Manual Function Test was used to assess functional recovery of the shoulder. Results: At the end of the treatment, it was seen that there was a decrease in the tone of the upper trapezius muscle and myoelectric activity and an increase in the tone of the deltoideus muscle. According to MFT results, there was a significant improvement in the percentage of shoulder function at the end of treatment. There was no improvement in hand function. In our study, EMG biofeedback training was found to be effective in improving shoulder function in hemiplegic patients. Conclusion: Preliminary results in this study suggested that in hemiplegic patients, the use of EMG biofeedback with shoulder exercises in the clinic, resulted in favorable outcomes in the treatment

Might There Be a Link Between Intron 3 VNTR Polymorphism in the XRCC4

DNA repair genes are involved in several diseases such as cancers and autoimmune diseases. Previous studies indicated that a DNA repair system was involved in the development of rheumatoid arthritis (RA). In this study, we aimed to examine whether four polymorphisms in the DNA repair genes (xeroderma pigmentosum complementation group D [XPD], X-ray repair cross-complementing group 1 [XRCC1], and X-ray repair cross-complementing group 4 [XRCC4]) were associated with RA. Sixty-five patients with RA and 70 healthy controls (HCs) were examined for XPD (A-751G), XRCC1 (A399G), and XRCC4 (intron 3 VNTR and G-1394T) polymorphisms. All polymorphisms were genotyped by PCR and/or PCR-RFLP. The association between the polymorphisms and RA was analyzed using the chi-square test and de Finetti program. The intron 3 VNTR polymorphism in the XRCC4 gene showed an association with RA patients. The DI genotype was found lower in RA patients (chi(2)=8.227; p=0.0021), while the II genotype was higher in RA patients (chi(2)=5.285; p=0.010). There were deviations from the Hardy-Weinberg Equilibrium (HWE) in both intron 3 VNTR and G-1394T polymorphisms in the XRCC4 gene and in the polymorphism in the XRCC1 gene, and the observed genotype counts deviated from those expected according to the HWE (p=0.027, 0.004, and 0.002, respectively); however, there was no deviation in the other gene polymorphisms. There is no statistical difference between the RA patients and HCs for XPD (A-751G), XRCC1 (A399G), and XRCC4 (G-1394T) gene polymorphisms (p>0.05). Although XPD (A-751G), XRCC1 (A399G), and XRCC4 (G-1394T) gene polymorphisms have been extensively investigated in different clinical pictures, this is the first study to evaluate the role of these polymorphisms in the genetic etiopathogenesis of RA in Turkish patients. In conclusion, we suggested that the intron 3 VNTR polymorphism in the XRCC4 gene may be associated with the etiopathogenesis of RA as a marker of immune aging

Might There Be a Link Between Intron 3 VNTR Polymorphism in the XRCC4 DNA Repair Gene and the Etiopathogenesis of Rheumatoid Arthritis?

DNA repair genes are involved in several diseases such as cancers and autoimmune diseases. Previous studies indicated that a DNA repair system was involved in the development of rheumatoid arthritis (RA). In this study, we aimed to examine whether four polymorphisms in the DNA repair genes (xeroderma pigmentosum complementation group D [XPD], X-ray repair cross-complementing group 1 [XRCC1], and X-ray repair cross-complementing group 4 [XRCC4]) were associated with RA. Sixty-five patients with RA and 70 healthy controls (HCs) were examined for XPD (A-751G), XRCC1 (A399G), and XRCC4 (intron 3 VNTR and G-1394T) polymorphisms. All polymorphisms were genotyped by PCR and/or PCR-RFLP. The association between the polymorphisms and RA was analyzed using the chi-square test and de Finetti program. The intron 3 VNTR polymorphism in the XRCC4 gene showed an association with RA patients. The DI genotype was found lower in RA patients (chi(2)=8.227; p=0.0021), while the II genotype was higher in RA patients (chi(2)=5.285; p=0.010). There were deviations from the Hardy-Weinberg Equilibrium (HWE) in both intron 3 VNTR and G-1394T polymorphisms in the XRCC4 gene and in the polymorphism in the XRCC1 gene, and the observed genotype counts deviated from those expected according to the HWE (p=0.027, 0.004, and 0.002, respectively); however, there was no deviation in the other gene polymorphisms. There is no statistical difference between the RA patients and HCs for XPD (A-751G), XRCC1 (A399G), and XRCC4 (G-1394T) gene polymorphisms (p>0.05). Although XPD (A-751G), XRCC1 (A399G), and XRCC4 (G-1394T) gene polymorphisms have been extensively investigated in different clinical pictures, this is the first study to evaluate the role of these polymorphisms in the genetic etiopathogenesis of RA in Turkish patients. In conclusion, we suggested that the intron 3 VNTR polymorphism in the XRCC4 gene may be associated with the etiopathogenesis of RA as a marker of immune aging

The Relationship Between Cd 74 Levels, Macrophage Migration Inhibitory Factor Gene Polymorphism and Clinical Features in Patients with Ankylosing Spondylitis

Objective: In this study, the primary objective was to compare CD 74 antigen levels between patients with ankylosing spondylitis (AS) and healthy controls. The secondary objective was to investigate the distribution of Macrophage Migration Inhibitory Factor (MIF) 173 G/C polymorphisms in AS patients and a control group. Finally, it was also aimed to reveal the presence of a relationship between CD 74 antigen levels and MIF 173 G/C polymorphism

The clinical, functional, and radiological features of hand osteoarthritis: TLAR-osteoarthritis multi-center cohort study

Objectives: This study aims to evaluate the clinical, functional, and radiological features of hand osteoarthritis (OA) and to examine their relationships in different geographic samples of the Turkish population. Patients and methods: Between April 2017 and January 2019, a total of 520 patients (49 males, 471 females; mean age: 63.6 +/- 9.8 years) with hand OA were included in the study from 26 centers across Turkey by the Turkish League Against Rheumatism (TLAR). The demographic characteristics, grip strengths with Jamar dynamometer, duration of hand pain (month), the severity of hand pain (Visual Analog Scale [VAS]), and morning stiffness were evaluated. The functional disability was evaluated with Duruoz Hand Index (DHI). The Kellgren-Lawrence (KL) OA scoring system was used to assess the radiological stage of hand OA. Results: The DHI had significant correlations with VAS-pain (r=0.367, p0.05). The differences between the groups of radiological hand OA grades in terms of age (p=0.007), VAS-pain (p0.05 for all). Conclusion: In our population, the patients with hand OA had pain, functional disability, and weak grip strength. The functional impairment was significantly correlated with the severity of the pain, and the functional status was worse in high radiological hand OA grades