2,471 research outputs found
Empirical Study of Data Sharing by Authors Publishing in PLoS Journals
Many journals now require authors share their data with other investigators, either by depositing the data in a public repository or making it freely available upon request. These policies are explicit, but remain largely untested. We sought to determine how well authors comply with such policies by requesting data from authors who had published in one of two journals with clear data sharing policies.We requested data from ten investigators who had published in either PLoS Medicine or PLoS Clinical Trials. All responses were carefully documented. In the event that we were refused data, we reminded authors of the journal's data sharing guidelines. If we did not receive a response to our initial request, a second request was made. Following the ten requests for raw data, three investigators did not respond, four authors responded and refused to share their data, two email addresses were no longer valid, and one author requested further details. A reminder of PLoS's explicit requirement that authors share data did not change the reply from the four authors who initially refused. Only one author sent an original data set.We received only one of ten raw data sets requested. This suggests that journal policies requiring data sharing do not lead to authors making their data sets available to independent investigators
Sequential Extensions of Causal and Evidential Decision Theory
Moving beyond the dualistic view in AI where agent and environment are
separated incurs new challenges for decision making, as calculation of expected
utility is no longer straightforward. The non-dualistic decision theory
literature is split between causal decision theory and evidential decision
theory. We extend these decision algorithms to the sequential setting where the
agent alternates between taking actions and observing their consequences. We
find that evidential decision theory has two natural extensions while causal
decision theory only has one.Comment: ADT 201
CAERvest® – a novel endothermic hypothermic device for core temperature cooling: safety and efficacy testing
Microarray based expression profiling of BRCA1 mutated human tumours using a breast-specific platform to identify a profile of BRCA1 deficiency
Reading behaviour project report 2016 : ‘Digital Magpies’ - the academic reading habits of undergraduate students
Engagement with the Library is essential in delivering a successful student experience. A previous Library Impact Project found that students who use the Library more tend to achieve better academic results. However, analytics from library systems indicate declining book borrowing and electronic resource usage. Are students really reading less? Student academic reading patterns have adapted to the increase in digital resources. As a result they may be “reading smarter’’. Feedback indicates they expect to find and use information quickly, synthesising information from a variety of sources. As part of a commitment to improve retention and completion figures, the Library has initiated a Reading Behaviours project at the University of Salford, focused on the reading habits of undergraduate students. It explores what motivates their academic reading; whether reading patterns vary according to purpose or source, academic discipline, status, or age and what this means for our role in helping students to find resources. In light of findings, how should we tailor classroom training, e-learning and collaboration with academics to support the student journey? Several key issues have emerged during this project:1. Synthesizing information for an academic purpose2. Embedding information literacy as a flexible learning habit3. Supporting students as they adapt to new learning context
Bayesian Conditioning, the Reflection Principle, and Quantum Decoherence
The probabilities a Bayesian agent assigns to a set of events typically
change with time, for instance when the agent updates them in the light of new
data. In this paper we address the question of how an agent's probabilities at
different times are constrained by Dutch-book coherence. We review and attempt
to clarify the argument that, although an agent is not forced by coherence to
use the usual Bayesian conditioning rule to update his probabilities, coherence
does require the agent's probabilities to satisfy van Fraassen's [1984]
reflection principle (which entails a related constraint pointed out by
Goldstein [1983]). We then exhibit the specialized assumption needed to recover
Bayesian conditioning from an analogous reflection-style consideration.
Bringing the argument to the context of quantum measurement theory, we show
that "quantum decoherence" can be understood in purely personalist
terms---quantum decoherence (as supposed in a von Neumann chain) is not a
physical process at all, but an application of the reflection principle. From
this point of view, the decoherence theory of Zeh, Zurek, and others as a story
of quantum measurement has the plot turned exactly backward.Comment: 14 pages, written in memory of Itamar Pitowsk
The Dawn of Open Access to Phylogenetic Data
The scientific enterprise depends critically on the preservation of and open
access to published data. This basic tenet applies acutely to phylogenies
(estimates of evolutionary relationships among species). Increasingly,
phylogenies are estimated from increasingly large, genome-scale datasets using
increasingly complex statistical methods that require increasing levels of
expertise and computational investment. Moreover, the resulting phylogenetic
data provide an explicit historical perspective that critically informs
research in a vast and growing number of scientific disciplines. One such use
is the study of changes in rates of lineage diversification (speciation -
extinction) through time. As part of a meta-analysis in this area, we sought to
collect phylogenetic data (comprising nucleotide sequence alignment and tree
files) from 217 studies published in 46 journals over a 13-year period. We
document our attempts to procure those data (from online archives and by direct
request to corresponding authors), and report results of analyses (using
Bayesian logistic regression) to assess the impact of various factors on the
success of our efforts. Overall, complete phylogenetic data for ~60% of these
studies are effectively lost to science. Our study indicates that phylogenetic
data are more likely to be deposited in online archives and/or shared upon
request when: (1) the publishing journal has a strong data-sharing policy; (2)
the publishing journal has a higher impact factor, and; (3) the data are
requested from faculty rather than students. Although the situation appears
dire, our analyses suggest that it is far from hopeless: recent initiatives by
the scientific community -- including policy changes by journals and funding
agencies -- are improving the state of affairs
Very Cold Gas and Dark Matter
We have recently proposed a new candidate for baryonic dark matter: very cold
molecular gas, in near-isothermal equilibrium with the cosmic background
radiation at 2.73 K. The cold gas, of quasi-primordial abundances, is condensed
in a fractal structure, resembling the hierarchical structure of the detected
interstellar medium.
We present some perspectives of detecting this very cold gas, either directly
or indirectly. The H molecule has an "ultrafine" structure, due to the
interaction between the rotation-induced magnetic moment and the nuclear spins.
But the lines fall in the km domain, and are very weak. The best opportunity
might be the UV absorption of H in front of quasars. The unexpected cold
dust component, revealed by the COBE/FIRAS submillimetric results, could also
be due to this very cold H gas, through collision-induced radiation, or
solid H grains or snowflakes. The -ray distribution, much more
radially extended than the supernovae at the origin of cosmic rays
acceleration, also points towards and extended gas distribution.Comment: 16 pages, Latex pages, crckapb macro, 3 postscript figures, uuencoded
compressed tar file. To be published in the proceeedings of the
"Dust-Morphology" conference, Johannesburg, 22-26 January, 1996, D. Block
(ed.), (Kluwer Dordrecht
Differences in Disease Severity but Similar Telomere Lengths in Genetic Subgroups of Patients with Telomerase and Shelterin Mutations
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
- …