12 research outputs found

    Mud volcanoes in the Alboran Sea: evidence from micropaleontological and geophysical data.

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    25 pages, 9 figures, 9 tables.During the BASACALB-TTR9 cruise of the R/V Professor Logachev (1999), two mud volcanoes (called Marrakech and Granada) were discovered in the southern sector of the mud diapir province in the West Alboran Basin (WAB). This paper presents icropaleontological and geophysical data on these mud volcanoes from gravity core samples, sidescan sonar (OKEAN) images and high-resolution seismic lines. Mud breccia recovered from the Granada mud volcano is matrix-supported with well-consolidated clasts of limestone, marlstone, claystone, siltstone, sandstone and mudstone, whereas mud breccia from the Marrakech mud volcano contains unconsolidated clasts. The mud breccia matrix contains abundant Miocene calcareous nannofossils (CN), together with Pliocene^Pleistocene species and reworked late Cretaceous and Paleocene^Eocene species. CN dating indicates that clasts in the mud breccia derive from late Cretaceous, Paleocene, Eocene, and probable Miocene sediments. These data suggest that the mud diapirs and mud volcanoes in the WAB can be derived from the olistostromes of Unit VI, the basal stratigraphic sequence in the Alboran Sea basin. Unit VIconsists of lower Miocene sediments that incorporated late Cretaceous and Paleocene^Eocene materials and basement-derived rock fragments. The mud volcanic deposits are covered by a thin drape of pelagic marls, suggesting that these two volcanoes are currently inactive. Structures determined on highresolution seismic profiles across mud volcanoes and surrounding diapirs correspond to the late-stage, Pliocene-to- Quaternary diapir development. This stage is thought to have developed during a compressional tectonic setting that produced folding and wrench tectonics throughout the basin. Mud ascent at that time resulted in active diapirism and mud volcanoes on the seafloor.We are grateful to M.K. Ivanov, of the TTR program, for his all-encompassing help. Moreover, we wish to express our gratitude to the BASACALB TTR9 scienti¢c party. We thank referees J.A. Flores, E. De Kaenel, A. Kopf and N. Kenyon for their thoughtful comments and detailed criticism, which helped to clarify the manuscript. We also thank C. Laurin for her careful and detailed linguistic revision. Funding for the BASACALB Cruise and this work was provided by Project REN2001-3868-C03 (MCYT, Spain).Peer reviewe

    Technology development of hyperthermic pressurized intraperitoneal aerosol chemotherapy (hPIPAC)

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    Background!#!Optimized drug delivery systems are needed for intraperitoneal chemotherapy. The aim of this study was to develop a technology for applying pressurized intraperitoneal aerosol chemotherapy (PIPAC) under hyperthermic conditions (hPIPAC).!##!Methods!#!This is an ex-vivo study in an inverted bovine urinary bladder (IBUB). Hyperthermia was established using a modified industry-standard device (Humigard). Two entry and one exit ports were placed. Warm-humid CO!##!Results!#!Therapeutic hyperthermia (target tissue temperature 41-43 °C) could be established and maintained over 30 min. In the first phase (insufflation phase), tissue hyperthermia was created by insufflating continuously warm-humid CO!##!Discussion!#!We introduce a simple and effective technology for hPIPAC. hPIPAC is feasible in an ex-vivo model by using a combination of industry-standard medical devices after modification. Potential pharmacological and biological advantages of hPIPAC over PIPAC should now be evaluated
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