Guide to the use of Mariner images

Planetary imaging from unmanned spacecraft, almost exclusively done by digital systems, is examined. The Mars Mariner 9 television camera, representative of such systems, is considered. Each image consists of 700 lines, each containing 832 picture elements, or pixels. Each pixel contains nine binary bits of information capable of displaying 512 discrete brightness levels. Several problems inherent in television systems are discussed. These include nonuniform target response, residual images, noise, and blemishes. These defects can be removed to some extent by decalibration of the image. The final product is geometrically corrected for camera distortion and photometrically corrected. Several versions of the decalibrated images are available. The most generally useful are the geometrically corrected images with enhanced contrast. The Mariner 10 imaging of Mercury is briefly discussed

Making postgraduate students and supervisors aware of the role of emotions in the PhD process

Emotions are an integral part of the PhD process. A range of emotions are common and to be expected. How do emotions affect the PhD process for both postgraduate students and their supervisors? How can we make our emotions work positively for us in the PhD process? To explore answers to these questions, three lecturers currently supervising postgraduates and three postgraduates at various stages in their doctoral studies collectively pooled their experiences. We developed an interactive workshop that was recently conducted for postgraduate students at Murdoch University and at the Australian Association for Social Research annual conference 2002. This presentation will explore the role that emotions play in the PhD process and how supervisors and postgraduates alike can benefit from reflecting on this issue. A number of practical (and humorous) tips will be provided as well as examples from others' PhD experiences. The role of emotions at the beginning, middle and end of a PhD program will be explored. The data collection and analysis phases are a time when emotions may run riot. Trepidation is especially common when fieldwork or data collection is involved, as is anger when postgraduate's views about how the world works are challenged and then sadness (and relief!) when the data collection phase is finished. We will discuss how supervisors can assist their postgraduates to make these feelings work for them. The presentation will also explore the emotions that arise from the supervisor-postgraduate partnership

A systematic review of the role of bisphosphonates in metastatic disease

Objectives: To identify evidence for the role of bisphosphonates in malignancy for the treatment of hypercalcaemia, prevention of skeletal morbidity and use in the adjuvant setting. To perform an economic review of current literature and model the cost effectiveness of bisphosphonates in the treatment of hypercalcaemia and prevention of skeletal morbidity Data sources: Electronic databases (1966-June 2001). Cochrane register. Pharmaceutical companies. Experts in the field. Handsearching of abstracts and leading oncology journals (1999-2001). Review methods: Two independent reviewers assessed studies for inclusion, according to predetermined criteria, and extracted relevant data. Overall event rates were pooled in a meta-analysis, odds ratios ( OR) were given with 95% confidence intervals (CI). Where data could not be combined, studies were reported individually and proportions compared using chi- squared analysis. Cost and cost-effectiveness were assessed by a decision analytic model comparing different bisphosphonate regimens for the treatment of hypercalcaemia; Markov models were employed to evaluate the use of bisphosphonates to prevent skeletal-related events (SRE) in patients with breast cancer and multiple myeloma. Results: For acute hypercalcaemia of malignancy, bisphosphonates normalised serum calcium in >70% of patients within 2-6 days. Pamidronate was more effective than control, etidronate, mithramycin and low-dose clodronate, but equal to high dose clodronate, in achieving normocalcaemia. Pamidronate prolongs ( doubles) the median time to relapse compared with clodronate or etidronate. For prevention of skeletal morbidity, bisphosphonates compared with placebo, significantly reduced the OR for fractures (OR [95% CI], vertebral, 0.69 [0.57-0.84], non-vertebral, 0.65 [0.54-0.79], combined, 0.65 [0.55-0.78]) radiotherapy 0.67 [0.57-0.79] and hypercalcaemia 0.54 [0.36-0.81] but not orthopaedic surgery 0.70 [0.46-1.05] or spinal cord compression 0.71 [0.47-1.08]. However, reduction in orthopaedic surgery was significant in studies that lasted over a year 0.59 [0.39-0.88]. Bisphosphonates significantly increased the time to first SRE but did not affect survival. Subanalyses were performed for disease groups, drugs and route of administration. Most evidence supports the use of intravenous aminobisphosphonates. For adjuvant use of bisphosphonates, Clodronate, given to patients with primary operable breast cancer and no metastatic disease, significantly reduced the number of patients developing bone metastases. This benefit was not maintained once regular administration had been discontinued. Two trials reported significant survival advantages in the treated groups. Bisphosphonates reduce the number of bone metastases in patients with both early and advanced breast cancer. Bisphosphonates are well tolerated with a low incidence of side-effects. Economic modelling showed that for acute hypercalcaemia, drugs with the longest cumulative duration of normocalcaemia were most cost-effective. Zoledronate 4 mg was the most costly, but most cost-effective treatment. For skeletal morbidity, Markov models estimated that the overall cost of bisphosphonate therapy to prevent an SRE was pound250 and pound1500 per event for patients with breast cancer and multiple myeloma, respectively. Bisphosphonate treatment is sometimes cost-saving in breast cancer patients where fractures are prevented. Conclusions: High dose aminobisphosphonates are most effective for the treatment of acute hypercalcaemia and delay time to relapse. Bisphosphonates significantly reduce SREs and delay the time to first SRE in patients with bony metastatic disease but do not affect survival. Benefit is demonstrated after administration for at least 6-12 months. The greatest body of evidence supports the use of intravenous aminobisphosphonates. Further evidence is required to support use in the adjuvant setting

From evaluation towards an agenda for quality improvement

For many students and lecturers evaluation is confined to some form of survey. Whilst these can provide useful feedback, their focus is likely to reflect the values and norms of those commissioning and undertaking the evaluation. For real improvements in quality to occur both lecturers’ and students’ perspectives of factors that are important need to be made explicit and understood. Drawing upon literature relating to service quality and in particular the Service Template, this article outlines and evaluates an alternative approach for establishing students’ and lecturers’ perspectives, obtaining feedback and developing an agenda for improvement. Using the example of dissertation supervision, it is argued that a revised Template Process operating within a process consultation framework can meet these concerns. The article concludes with a discussion of the applicability of the Template Process to evaluating teaching and learning

Southern Sky Redshift Survey: Clustering of Local Galaxies

We use the two-point correlation function to calculate the clustering properties of the recently completed SSRS2 survey. The redshift space correlation function for the magnitude-limited SSRS2 is given by xi(s)=(s/5.85 h-1 Mpc)^{-1.60} for separations between 2 < s < 11 h-1 Mpc, while our best estimate for the real space correlation function is xi(r) = (r/5.36 h-1 Mpc)^{-1.86}. Both are comparable to previous measurements using surveys of optical galaxies over much larger and independent volumes. By comparing the correlation function calculated in redshift and real space we find that the redshift distortion on intermediate scales is small. This result implies that the observed redshift-space distribution of galaxies is close to that in real space, and that beta = Omega^{0.6}/b < 1, where Omega is the cosmological density parameter and b is the linear biasing factor for optical galaxies. We also use the SSRS2 to study the dependence of xi on the internal properties of galaxies. We confirm earlier results that luminous galaxies (L>L*) are more clustered than sub-L* galaxies and that the luminosity segregation is scale-independent. We find that early types are more clustered than late types, but that in the absence of rich clusters, the relative bias between early and late types in real space, is not as strong as previously estimated. Furthermore, both morphologies present a luminosity-dependent bias, with the early types showing a slightly stronger dependence on luminosity. We also find that red galaxies are significantly more clustered than blue ones, with a mean relative bias stronger than that seen for morphology. Finally, we find that the relative bias between optical and iras galaxies in real space is b_o/b_I $\sim$ 1.4.Comment: 43 pages, uses AASTeX 4.0 macros. Includes 8 tables and 16 Postscript figures, updated reference

Inspiring Music for All: next steps in innovation, improvement and integration

The report, funded by the Paul Hamlyn Foundation, provides an overview of schools-based music education in England. It represents the outcomes of research undertaken in January and February 2014 which included detailed literature reviews, personal interviews with thirty-five specialists involved in leading various organisations responsible for different aspects of music education, focus group discussions and an on-line survey of the music education workforce that generated 515 responses. The findings suggest that the place and status of music in schools vary widely across the country. The best music in schools is significantly more inclusive, more musically diverse and better quality that it was a decade ago. However, the quality and reach of schools-based music education is still unacceptably variable and inconsistent at both primary and secondary levels. Detailed findings and recommendations are included in the report

Bayes-X: a Bayesian inference tool for the analysis of X-ray observations of galaxy clusters

We present the first public release of our Bayesian inference tool, Bayes-X, for the analysis of X-ray observations of galaxy clusters. We illustrate the use of Bayes-X by analysing a set of four simulated clusters at z=0.2-0.9 as they would be observed by a Chandra-like X-ray observatory. In both the simulations and the analysis pipeline we assume that the dark matter density follows a spherically-symmetric Navarro, Frenk and White (NFW) profile and that the gas pressure is described by a generalised NFW (GNFW) profile. We then perform four sets of analyses. By numerically exploring the joint probability distribution of the cluster parameters given simulated Chandra-like data, we show that the model and analysis technique can robustly return the simulated cluster input quantities, constrain the cluster physical parameters and reveal the degeneracies among the model parameters and cluster physical parameters. We then analyse Chandra data on the nearby cluster, A262, and derive the cluster physical profiles. To illustrate the performance of the Bayesian model selection, we also carried out analyses assuming an Einasto profile for the matter density and calculated the Bayes factor. The results of the model selection analyses for the simulated data favour the NFW model as expected. However, we find that the Einasto profile is preferred in the analysis of A262. The Bayes-X software, which is implemented in Fortran 90, is available at http://www.mrao.cam.ac.uk/facilities/software/bayesx/.Comment: 22 pages, 11 figure

Critical phenomena in a highly constrained classical spin system: Neel ordering from the Coulomb phase

Many classical, geometrically frustrated antiferromagnets have macroscopically degenerate ground states. In a class of three-dimensional systems, the set of degenerate ground states has power-law correlations and is an example of a Coulomb phase. We investigate Neel ordering from such a Coulomb phase, induced by weak additional interactions that lift the degeneracy. We show that the critical point belongs to a universality class that is different from the one for the equivalent transition out of the paramagnetic phase, and that it is characterised by effective long-range interactions; alternatively, ordering may be discontinuous. We suggest that a transition of this type may be realised by applying uniaxial stress to a pyrochlore antiferromagnet.Comment: 4 pages, 3 figure

Modelling of the photooxidation of toluene: conceptual ideas for validating detailed mechanisms

Toluene photooxidation is chosen as an example to examine how simulations of smog-chamber experiments can be used to unravel shortcomings in detailed mechanisms and to provide information on complex reaction systems that will be crucial for the design of future validation experiments. The mechanism used in this study is extracted from the Master Chemical Mechanism Version 3 (MCM v3) and has been updated with new modules for cresol and g-dicarbonyl chemistry. Model simulations are carried out for a toluene-NO_x experiment undertaken at the European Photoreactor (EUPHORE). The comparison of the simulation with the experimental data reveals two fundamental shortcomings in the mechanism: OH production is too low by about 80%, and the ozone concentration at the end of the experiment is over-predicted by 55%. The radical budget was analysed to identify the key intermediates governing the radical transformation in the toluene system. Ring-opening products, particularly conjugated g-dicarbonyls, were identified as dominant radical sources in the early stages of the experiment. The analysis of the time evolution of radical production points to a missing OH source that peaks when the system reaches highest reactivity. First generation products are also of major importance for the ozone production in the system. The analysis of the radical budget suggests two options to explain the concurrent under-prediction of OH and over-prediction of ozone in the model: 1) missing oxidation processes that produce or regenerate OH without or with little NO to NO₂ conversion or 2) NO₃ chemistry that sequesters reactive nitrogen oxides into stable nitrogen compounds and at the same time produces peroxy radicals. Sensitivity analysis was employed to identify significant contributors to ozone production and it is shown how this technique, in combination with ozone isopleth plots, can be used for the design of validation experiments

Examining the potential public health benefit of offering STI testing to men in amateur football clubs: evidence from cross-sectional surveys

Background: In Britain, young people continue to bear the burden of sexually transmitted infections (STIs) so efforts are required, especially among men, to encourage STI testing. The SPORTSMART study trialled an intervention that sought to achieve this by offering chlamydia and gonorrhoea test-kits to men attending amateur football clubs between October and December 2012. With football the highest participation team sport among men in England, this paper examines the potential public health benefit of offering STI testing to men in this setting by assessing their sociodemographic characteristics, sexual behaviours, and healthcare behaviour and comparing them to men in the general population. Methods: Data were collected from 192 (male) members of 6 football clubs in London, United Kingdom, aged 18–44 years via a 20-item pen-and-paper self-completion questionnaire administered 2 weeks after the intervention. These were compared to data collected from 409 men of a similar age who were resident in London when interviewed during 2010–2012 for the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3), a national probability survey that used computer-assisted-personal-interviewing with computer-assisted-self-interview. Age standardisation and multivariable regression were used to account for sociodemographic differences between the surveys. Results: Relative to men in the general population, SPORTSMART men were younger (32.8 % vs. 21.7 % aged under 25 y), and more likely to report (all past year) at least 2 sexual partners (adjusted odds ratio, AOR: 3.25, 95 % CI: 2.15–4.92), concurrent partners (AOR: 2.05, 95 % CI: 1.39–3.02), and non-use of condoms (AOR: 2.17, 95 % CI: 1.39–3.41). No difference was observed in STI/HIV risk perception (AOR for reporting “not at all at risk” of STIs: 1.25, 95 % CI: 0.76–2.04; of HIV: AOR: 1.54, 95 % CI: 0.93–2.55), nor in reporting STI testing in the past year (AOR: 0.83, 95 % CI: 0.44–1.54), which was reported by only one in six men. Conclusions: Relative to young men in the general population, football club members who completed the SPORTSMART survey reported greater sexual risk behaviour but similar STI/HIV risk perception and STI testing history. Offering STI testing in amateur football clubs may therefore widen access to STI testing and health promotion messages for men at higher STI risk, which, given the minority currently testing and the popularity of football in England, should yield both individual and public health benefit